Phase Behavior of Pentaglycerol Monostearic and Monooleic Acid Esters in Water

“…Dilute aqueous solutions of C 18 G 5 and C 18:1 G 5 in water are essentially the dispersion of surfactant solid (α-gel form) and L α , respectively. Phase behavior of C 18 G 5 and C 18:1 G 5 in water has been recently published [29] and the complete phase diagrams are shown in Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

Aqueous foam stabilized by dispersed surfactant solid and lamellar liquid crystalline phase

Shrestha

Acharya

Sharma

et al. 2006

Journal of Colloid and Interface Science

Self Cite

View full text Add to dashboard Cite

“…The use of polyglycerol fatty acid esters in foods 3,4) , cosmetics 5,6) , detergents 7) and pharmaceutics 8,9) are increasing day-byday due to its low toxicity and ease of biodegradability. Besides, due to their capability of a-solid formation in water 10,11) or oils 12) , they are mostly desired for the efficient foam and emulsion stabilization purposes [13][14][15] . Many attempts have been made to clarify the functions of the polyglycerol fatty acid esters.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Surface Tension and Surface Dilatational Elasticity Properties of Mixed Surfactant/Protein Systems

et al. 2008

Self Cite

View full text Add to dashboard Cite

We present the study on dynamic surface tension and surface dilatational elasticity properties of dilute aqueous systems of pentaglycerol fatty acid esters (pentaglycerol monostearate, C 18 G 5 , and pentaglycerol monooleate, C 18:1 G 5 ), whey protein, sodium caseinate, and mixed surfactant and protein at room temperature. The adsorption kinetics at the air-liquid interface has been studied by bubble pressure tensiometer and the oscillation bubble (rising drop) method. It has been shown that the dynamic surface tension curve basically presents two-regions; namely induction region and rapid fall region. During the induction time the adsorption is the diffusion-controlled process of amphiphilic surfactant or protein molecules from the bulk of the solution to the interface. Whey protein and sodium caseinate showed longer induction time 10000 ms compared to the surfactant systems, where induction time was estimated to be 1000 ms. However, in both the protein and surfactant systems, the induction time goes on decreasing with increasing the concentrations. The similar behavior was observed in the mixed system, and lower surface tension values were observed at higher concentrations. The fitting of the experimental data to the theoretical equation shows the presence of two relaxation mechanisms of widely different time scale for the adsorption of surfactant or protein molecules at the interface. The relaxation time strongly varies with the concentrations following the power law, and at fixed concentration it was the highest for whey protein and the lowest for C 18:1 G 5 system. The surface dilatational elasticity determined within the frequency range of 0.1 to 1 cycle/s supports the dynamic surface tension data.

show abstract

“…Õ /Cremophore RH40 Õ (13.5) mixture. This may be due to the fact that the raw materials used for synthesis of surfactants are usually mixtures of fatty acids with different hydrocarbon chain lengths and fraction of un-reacted polyoxyethylene, polyglycerol and ethoxyls which may influence their nanoemulsifying efficiency [38,39]. In addition, variation in chemical structure of these non-ionic surfactants could be another factor for influencing the nanoemulsifying efficiency of co-surfactants.…”

Section: Screening Of Co-surfactantsmentioning

confidence: 99%

Enhanced transdermal delivery of carvedilol using nanoemulsion as a vehicle

Rizwan¹,

Aqil²,

Azeem³

et al. 2010

Journal of Experimental Nanoscience

View full text Add to dashboard Cite

The aim of the present study was to develop nanoemulsion as a possible vehicle for enhanced transdermal penetration of carvedilol (CVD). For screening of nanoemulsion components, solubility of CVD in oils, surfactants and co-surfactants was determined. Various surfactants and co-surfactants were screened for their ability to nanoemulsify the selected oily phases. The obtained results indicated that Acconon CC6Õ had shown good nanoemulsification efficiency (minimum surfactant required S min ¼ 46.52% w/w) among the selected surfactants and further improved in presence of Õ (S min ¼ 37.11% w/w). The ranges of nanoemulsion existence were delineated through the construction of the pseudo-ternary phase diagram at different ratio of surfactant mixture (S/ CoS), and various nanoemulsions were selected from phase diagram of S/CoS ratio 1 : 1. The effect of content of oil and S/CoS (1 : 1) on the skin permeation of CVD was evaluated through an excised wistar rat skin using Franz diffusion cell. All the nanoemulsions showed a high skin permeation rate (92.251-161.53 mg/ cm 2 /h), good enhancement ratio (3.5-6.2) and high permeability coefficient in comparison to control groups. The optimised nanoemulsion formulation with the highest skin permeation rate (161.53 mg/cm 2 /h) consisted of 0.25% w/w CVD, 12.5% w/w Miglyol 810 Õ , 50% w/w Acconon CC6 Õ /CO-20 Õ (1 : 1) and water. The above formulation had the smallest mean globules size (9.28 nm). The superior transdermal flux of CVD may be due to nanorange size of oil globules that lead to intimate contact with the skin layer. These studies suggest that the nanoemulsion system is a promising vehicle for the transdermal delivery of CVD.

show abstract

Phase Behavior of Pentaglycerol Monostearic and Monooleic Acid Esters in Water

Cited by 15 publications

References 10 publications

Aqueous foam stabilized by dispersed surfactant solid and lamellar liquid crystalline phase

Aqueous foam stabilized by dispersed surfactant solid and lamellar liquid crystalline phase

Dynamic Surface Tension and Surface Dilatational Elasticity Properties of Mixed Surfactant/Protein Systems

Enhanced transdermal delivery of carvedilol using nanoemulsion as a vehicle

Contact Info

Product

Resources

About