Phase Angle Is Moderately Associated With Muscle Quality and Functional Capacity, Independent of Age and Body Composition in Older Women

Tomeleri, Crisieli M.; Cavalcante, Edilaine F.; Antunes, Melissa; Nabuco, Hellen C G; Souza, Mariana Ferreira de; Teixeira, Denílson C.; Gobbo, Luís Alberto; Silva, Analiza M.; Cyrino, Edílson Serpeloni

doi:10.1519/jpt.0000000000000161

Cited by 60 publications

(58 citation statements)

References 31 publications

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“…In support of phase angle as a surrogate measure of muscle quality and consistent with the overall results of the current study, Tomeleri et al . recently reported significant associations between phase angle, muscle quality, and functional capacity in a cohort of elderly women.…”

Section: Discussionsupporting

confidence: 91%

“…The critical frequency is the frequency at which the largest reactance and cell membrane capacitance is observed and the one closest linked to function and outcomes. 42,43 In support of phase angle as a surrogate measure of muscle quality and consistent with the overall results of the current study, Tomeleri et al 44 recently reported significant associations between phase angle, muscle quality, and functional capacity in a cohort of elderly women. The authors defined muscle 'quality' as total strength per unit muscle mass, specifically as 1-repetition max tests (chest press, knee extension, and preacher curl exercises)/LST.…”

Section: Strength Prediction Modelssupporting

confidence: 90%

“…An important implication of our findings and those of Yamada et al ., Taniguchi et al ., and Tomerli et al . is that estimates of skeletal muscle mass can be augmented with BIA measurements when evaluating patients for the presence of sarcopenia and related functional limitations.…”

Section: Discussionsupporting

confidence: 68%

“…An important implication of our findings and those of Yamada et al, 27,21 Taniguchi et al, 24 and Tomerli et al 44 is that estimates of skeletal muscle mass can be augmented with BIA measurements when evaluating patients for the presence of sarcopenia and related functional limitations. We anticipate that measures of muscle mass and quality could eventually be combined to create a score that would predict the risk of developing sarcopenia or related disorders rather than be used to simply predict muscle function.…”

Section: Concordance With Earlier Studiessupporting

confidence: 67%

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Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Bourgeois

Fan

Johannsen

et al. 2018

J cachexia sarcopenia muscle

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Background Measures of skeletal muscle function decline at a faster rate with ageing than do indices of skeletal muscle mass. These observations have been attributed to age‐related changes in muscle quality, another functional determinant separate from skeletal muscle mass. This study tested the hypothesis that improved predictions of skeletal muscle strength can be accomplished by combining clinically available measures of skeletal muscle mass and quality. Methods The participants included 146 healthy adult (age ≥ 18 years, range 18–77 years; X ± SD 47 ± 17 years and body mass index 16.5–51.8 kg/m 2 ; 27.7 ± 6.2 kg/m 2 ) men ( n = 60) and women ( n = 86) in whom skeletal muscle mass was estimated as appendicular lean soft tissue (LST) measured by dual‐energy X‐ray absorptiometry and skeletal muscle quality as bioimpedance analysis‐derived phase angle and B‐mode‐evaluated echogenicity of mid‐thigh skeletal muscle. Strength of the right leg and both arms was quantified as knee isokinetic extension and handgrip strength using dynamometers. The statistical significance of adding phase angle or echogenicity to strength prediction multiple regression models that included extremity‐specific LST and other covariates (e.g. age and sex) was evaluated to test the study hypothesis. Results Right leg LST mass alone was significantly ( P < 0.0001) correlated with isokinetic right leg strength ( R 2 = 0.57). The addition of segmental phase angle measured in the right leg at 50 kHz increased the R 2 of this model to 0.66 ( P < 0.0001); other phase angle frequencies (5 and 250 kHz) did not contribute significantly to these models. Results were similar for both right and left arm handgrip strength prediction models. Adding age and sex as model covariates increased the R 2 values of these models further (e.g. right leg strength model R 2 increased to 0.71), but phase angle continued to remain a significant (all P < 0.01) predictor of extremity strength. Similarly, when predicting isokinetic right leg strength, mid‐thigh skeletal muscle echogenicity added significantly ( P < 0.0001) to right leg LST, increasing R 2 from 0.57 to 0.64; age was a significant ( P < 0.0001) covariate in this model, increasing R 2 further to 0.68. Conclusions The hypothesis of the current study was confirmed, strongly supporting and extending earlier reports by quantifying the combined independent effects of skeletal muscle mass and quality on lo...

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Section: Discussionsupporting

confidence: 91%

Section: Strength Prediction Modelssupporting

confidence: 90%

Section: Discussionsupporting

confidence: 68%

Section: Concordance With Earlier Studiessupporting

confidence: 67%

See 2 more Smart Citations

Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Bourgeois

Fan

Johannsen

et al. 2018

J cachexia sarcopenia muscle

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“…Impedance consists of two variables: resistance (R), that determines the state of hydration of the tissue, and reactance (Xc), that determines the amount of energy that can be accumulated in the tissue (12). The phase angle (PhA), which is a relation between Xc and R, has been interpreted as an indicator of cell membrane integrity, in addition to associating muscle mass, strength and body fat (13)(14)(15). PhA decreases with the aging process, especially due to the reduction of Xc, and and is related to the reduction of the proportion of total body water (12) and of the relationship between extracellular and intracellular water (16,17).…”

Section: Introductionmentioning

confidence: 99%

Postural Control is Associated with Functionality and Cell Health in Elderly.

BERTOLINI

Silva

Santos

et al. 2020

Preprint

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Background: Alterations in cellular health and postural control occur with aging and contribute to the increased risk of falls.The aim of this study was to analyse the relationship between static balance in relation to functionality and cell health. Methods: We evaluated 21 elderly people of both sexes, aged ≥60 years (11 men: 77 ± 9 years; 10 women: 74 ± 10 years) . The ability and quality of maintaining balance in standing posture measured by the movement of the pressure center (CoP) for seven positions: feet separated open and closed eyes (FSEO, FSEC), feet together open and closed eyes (FTEO, FTEC), semi-tandem open and closed eyes (STEO, STEC), and one-legged-support (OLS). Cellular health was measured by means of electrical bioimpedance (BIA) and functionality through the Timed Up and Go Test (TUG) and Short Physical Performance Battery (SPPB). Results: In the analysis of the mediolateral velocity of the positions FSEO, FSEC, FTEC, and STEO on the platform, an inverse correlation between balance and bioelectrical impedance variables were verified for all models, with a coefficient of explanation (r2) varying between 20% (resistance in FSEO position) and 74% (reactance in STEO position, Model 3). Inverse and significant correlations between reactance and phase angle in the OLS position was verified, in all adjustment models, with coefficient of explanation varying between 62% (phase angle, OLS area, Model 1) and 91% (same variables, Model 3). In the analysis of mediolateral velocity for the STEC position, positive correlation with TUG and an inverse correlation with reactance, resistance, phase angle were observed, with coefficient of explanation varying between 21% (resistance, Model 1) and 67% (reactance, Model 3).Conclusions: The postural control is linearly related to bioimpedance parameters and functionality in elderly. The assessment of balance can provide important information on the health condition of the elderly, and furnishes useful insights for prevention and treatment strategies.

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Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality

Akamatsu

Kusakabe

Arai

et al. 2021

J cachexia sarcopenia muscle

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Background Methods that facilitate muscle quality measurement may improve the diagnosis of sarcopenia. Current research has focused on the phase angle (PhA) obtained through bioelectrical impedance analysis (BIA) as an indicator of cellular health, particularly cell membrane integrity and cell function. The current study therefore aimed to evaluate the relationship between the PhA and muscle quality and muscle‐related parameters and to determine factors associated with the PhA. Moreover, we attempted to determine the cut‐off value of PhA for predicting sarcopenia. Methods First‐year university students (830 male students, 18.5 ± 0.6 years old; 422 female students, 18.3 ± 0.5 years old) and community‐dwelling elderly individuals (70 male individuals, 74.4 ± 5.5 years old; 97 female individuals, 73.1 ± 6.4 years old) were included. PhA and other body composition data were measured using BIA, while muscle quality was calculated by dividing handgrip strength by upper limbs muscle mass. The relationship between PhA and the aforementioned parameters were then analysed, after which the cut‐off value of PhA for predicting sarcopenia was examined. Results Multiple linear regression analysis revealed that age, skeletal muscle mass index (SMI), and muscle quality were independently associated with PhA in both sexes [male (age: standardized regression coefficient (β) = −0.43, P < 0.001, SMI: β = 0.61, P < 0.001, muscle quality: β = 0.13, P < 0.001) and female (age: β = −0.56, P < 0.001, SMI: β = 0.52, P < 0.001, muscle quality: β = 0.09, P = 0.007)]. Participants with sarcopenia had a significantly lower PhA compared with those without it (sarcopenia vs. non‐sarcopenia: young male participants, 5.51 ± 0.41° vs. 6.25 ± 0.50°, P < 0.001; young female participants, 4.88 ± 0.16° vs. 5.37 ± 0.44°, P = 0.005; elderly female participants: 4.14 ± 0.29° vs. 4.63 ± 0.42°, P = 0.009). Although no significant findings were observed in elderly male participants, the same tendency was noted. Receiver operating characteristic (ROC) curve analysis indicated that PhA had good predictive ability for sarcopenia in young male, elderly male, young female, and elderly female participants (area under the ROC curve of 0.882, 0.838, 0.865, and 0.850, with cut‐off PhA values of 5.95°, 5.04°, 5.02°, and 4.20° for predicting sarcopenia, respectively). Conclusions The PhA reflected muscle quality and exhibited good accuracy in detecting sarcopenia, suggesting its utility as an index for easily measuring muscle quality, which could improve the diagnosis of sarcopenia.

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Phase Angle Is Moderately Associated With Muscle Quality and Functional Capacity, Independent of Age and Body Composition in Older Women

Abstract: Our findings suggest that healthy elderly women with higher values of PhA have a better muscle quality and functionality, regardless of age and body composition.

Cited by 60 publications

References 31 publications

Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Improved strength prediction combining clinically available measures of skeletal muscle mass and quality

Postural Control is Associated with Functionality and Cell Health in Elderly.

Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality

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