Phase Angle as a Potential Screening Tool in Adults with Metabolic Diseases in Clinical Practice: A Systematic Review

Praget-Bracamontes, Samantha; González-Arellanes, Rogelio; Aguilar-Salinas, Carlos; Martagón, Alexandro J.

doi:10.3390/ijerph20021608

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Furthermore, Praget‐Bracamontes et al. ( 2023 ) reinforced the role of PhA by showing its association with key aspects of MetS, including obesity, hyperuricemia, and vitamin D deficiency. This study emphasizes that low PhA values are correlated with worse outcomes in metabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

Glycated hemoglobin (HbA1c) is independently associated with the bioelectrical impedance phase angle in junior sumo wrestlers: A pilot study

Khatun,

Ogawa,

Uchizawa

et al. 2024

Physiological Reports

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The study explores the relationship between phase angle (PhA), an indicator of cellular health, and metabolic health parameters among junior sumo wrestlers in Japan. Given the demanding lifestyle and high‐energy diets of sumo wrestlers that predispose them to metabolic syndrome post‐retirement, this study focuses on a younger cohort. The primary aim is to evaluate if PhA could serve as an early indicator of metabolic health issues within this unique demographic. A total of 14 sumo wrestlers aged 9–17 years were assessed to determine the relationship between PhA and various metabolic markers, including glycated hemoglobin (HbA1c), using a TANITA MC‐780A‐N body composition analyzer and standard blood tests. Bivariate regression analysis and Pearson's correlation revealed a negative relationship between PhA and HbA1c even after adjusting for age and weight (ß = −0.496, r2 = 0.776, r = −0.756, p = 0.004). The results indicate a significant negative relationship between PhA and HbA1c levels, suggesting that lower PhA values, which indicate poorer cellular integrity, are associated with higher HbA1c levels, signifying impaired glycemic control. These findings underscore the potential of PhA as a valuable biomarker for monitoring metabolic health in young sumo wrestlers, with implications for early intervention and management strategies.

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Section: Discussionmentioning

confidence: 99%

Glycated hemoglobin (HbA1c) is independently associated with the bioelectrical impedance phase angle in junior sumo wrestlers: A pilot study

Khatun,

Ogawa,

Uchizawa

et al. 2024

Physiological Reports

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“…1A). Systematic reviews have been published on cancer [5,[7][8][9][10], sarcopenia [11], surgery [12], critical illness [13], heart failure and chronic kidney disease [14], obesity [15], metabolic diseases [16], coronavirus disease-2019 (COVID-19) [17] and in different diseases states [18]. Systematic reviews and meta-analysis to estimate mean PhA values in healthy individuals [19], critical illness [20], and cardiovascular diseases [21].…”

Section: Overview Of the Value Of Pha In Biomedical Researchmentioning

confidence: 99%

Future lines of research on phase angle: Strengths and limitations

Guerrero

García-García

Talluri³

et al. 2023

Rev Endocr Metab Disord

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Bioelectrical impedance analysis (BIA) is the most widely used technique in body composition analysis. When we focus the use of phase sensitive BIA on its raw parameters Resistance (R), Reactance (Xc) and Phase Angle (PhA), we eliminate the bias of using predictive equations based on reference models. In particular PhA, have demonstrated their prognostic utility in multiple aspects of health and disease. In recent years, as a strong association between prognostic and diagnostic factors has been observed, scientific interest in the utility of PhA has increased. In the different fields of knowledge in biomedical research, there are different ways of assessing the impact of a scientific-technical aspect such as PhA. Single frequency with phase detection bioimpedance analysis (SF-BIA) using a 50 kHz single frequency device and tetrapolar wrist-ankle electrode placement is the most widely used bioimpedance approach for characterization of whole-body composition. However, the incorporation of vector representation of raw bioelectrical parameters and direct mathematical calculations without the need for regression equations for the analysis of body compartments has been one of the most important aspects for the development of research in this area. These results provide new evidence for the validity of phase-sensitive bioelectrical measurements as biomarkers of fluid and nutritional status. To enable the development of clinical research that provides consistent results, it is essential to establish appropriate standardization of PhA measurement techniques. Standardization of test protocols will facilitate the diagnosis and assessment of the risk associated with reduced PhA and the evaluation of changes in response to therapeutic interventions. In this paper, we describe and overview the value of PhA in biomedical research, technical and instrumental aspects of PhA research, analysis of Areas of clinical research (cancer patients, digestive and liver diseases, critical and surgical patients, Respiratory, infectious, and COVID-19, obesity and metabolic diseases, Heart and kidney failure, Malnutrition and sarcopenia), characterisation of the different research outcomes, Morphofunctional assessment in disease-related malnutrition and other metabolic disorders: validation of PhA with reference clinical practice techniques, strengths and limitations. Based on the detailed study of the measurement technique, some of the key issues to be considered in future PhA research. On the other hand, it is important to assess the clinical conditions and the phenotype of the patients, as well as to establish a disease-specific clinical profile. The appropriate selection of the most critical outcomes is another fundamental aspect of research.

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“…The phase angle (PhA), which is one of the body composition indices, may have broad potential in assessing the nutritional status and stage of the disease, as well as in estimating the risk of postoperative complications, disability, and even mortality 1 ) . Furthermore, PhA may be a potential screening tool in clinical practice to evaluate different biomarkers, cardiovascular risk, and nutritional diagnosis in metabolic diseases in adults 2 ) , and reacts to physical training and detraining 3 ) . Therefore, PhA is a feasible evaluation for assessing cellar health and could be a potential marker of inflammation and oxidative stress 4 ) .…”

Section: Introductionmentioning

confidence: 99%

Phase angle as a prognostic factor for one-year mortality in geriatric health service facility residents

Sato,

Kubo,

Tsukahara

et al. 2023

J Phys Ther Sci

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[Purpose] The present study aimed to investigate the association of phase angle with the continuing activities of residents in a geriatric health service facility for one year. We compared the phase angle among current residents in a geriatric health service facility with those who died within one year. [Participants and Methods] This one-year prospective observational study included 149 residents who entered a geriatric health service facility. We divided participants into two groups: an over one-year survival group and a death within one year group. The receiver operating characteristic curves were created to determine the sensitivity and specificity for predicting one-year mortality based on the phase angle. [Results] The phase angle was significantly higher in the one-year survival group than in the death within one year group and was independently and significantly associated with one-year mortality using binomial logistic regression analysis. The phase angle was shown to have predictive power (based on the area under the receiver operating characteristic curve). Based on the calculation for identifying one-year survival, the optimal cut-off value for the phase angle was 2.95° (area under the receiver operating characteristic curve=0.76, sensitivity 55.6%, specificity 83.3%). [Conclusion] The phase angle may contribute to the prognosis of one-year mortality for residents of geriatric health service facilities.

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Phase Angle as a Potential Screening Tool in Adults with Metabolic Diseases in Clinical Practice: A Systematic Review

Cited by 6 publications

References 29 publications

Glycated hemoglobin (HbA1c) is independently associated with the bioelectrical impedance phase angle in junior sumo wrestlers: A pilot study

Glycated hemoglobin (HbA1c) is independently associated with the bioelectrical impedance phase angle in junior sumo wrestlers: A pilot study

Future lines of research on phase angle: Strengths and limitations

Phase angle as a prognostic factor for one-year mortality in geriatric health service facility residents

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