Phase analysis detects heterogeneity of myocardial deformation on cine MRI

Abstract

This is the pre peer-reviewed version of the following article, "Phase analysis detects heterogeneity of myocardial deformation on cine MRI", which in its final form has been published at Scand Cardiovasc J. This is the pre peer-reviewed version of the following article, "Phase analysis detects heterogeneity of myocardial deformation on cine MRI", which in its final form has been published at Scand Cardiovasc J. This is the pre peer-reviewed version of the following article, "Phase analysis detects heterogeneity of myocardial deformation on cine MRI", which in its final form has been published at Scand Cardiovasc J. 2015 Mar 10:1-24. [Epub ahead of print] PMID: 25752486.-3 - Abstract ObjectivesMyocardial scar will lead to heterogeneous left ventricular deformation. We hypothesized that a myocardial scar will display an elevated standard deviation of phase and that this effect could be compared with mechanical dispersion. DesignThirty patients (3 women and 27 men) were investigated 4-8 weeks after STelevation myocardial infarction treated with percutaneous coronary intervention.Seventeen had a scar area >75% in at least one antero-or inferoseptal segment (scar) and 13 had scar <1% (non-scar). The phase delays of velocity, displacement and strain were measured in the longitudinal direction, tangential to the endocardial outline, and in the radial direction, perpendicular to the tangent. ResultsThe standard deviation of phase in radial measurements differentiated scar patients from those without scar (p<0.01), while longitudinal measurements did so only for longitudinal strain. Likewise, the standard deviation for radial measurements of time to peak for segmental velocity, displacement and strain performed better than longitudinal measurements and equal to the results of phase. ConclusionPhase dispersion in deformation imaging may be used for detecting heterogeneous left ventricular contraction.This is the pre peer-reviewed version of the following article, "Phase analysis detects heterogeneity of myocardial deformation on cine MRI", which in its final form has been published at Scand Cardiovasc J.

Strain measurement on four-dimensional dynamic-ventilation CT: quantitative analysis of abnormal respiratory deformation of the lung in COPD

“…Strain analysis, which can express deformation of a tissue or organ in the human body, has been mainly used to assess myocardial motion using various four-dimensional (4D) imaging modalities, including echocardiography, magnetic resonance imaging (MRI), and computed tomography (CT) 1–11. Although various parameters based on strain measurements have been advocated by different software vendors, it is commonly accepted in the field of cardiology that strain is a sensitive parameter to assess regional function of the myocardium 4–11.…”

“…Strain analysis, which can express deformation of a tissue or organ in the human body, has been mainly used to assess myocardial motion using various four-dimensional (4D) imaging modalities, including echocardiography, magnetic resonance imaging (MRI), and computed tomography (CT) 1–11. Although various parameters based on strain measurements have been advocated by different software vendors, it is commonly accepted in the field of cardiology that strain is a sensitive parameter to assess regional function of the myocardium 4–11. It has also been reported that strain measurements reveal minor left ventricular modifications in athletes with common anomalies (ie, bicuspid aortic valve),3 which might be masked by apparently normal values of global cardiac function parameters, such as ejection fraction and stroke volume 12,13…”