Phase Aberration Correction for In Vivo Ultrasound Localization Microscopy Using a Spatiotemporal Complex-Valued Neural Network

Xing, Paul; Porée, Jonathan; Rauby, Brice; Malescot, Antoine; Martineau, Eric; Perrot, Vincent; Rungta, Ravi L.; Provost, Jean

doi:10.1109/tmi.2023.3316995

Cited by 5 publications

(3 citation statements)

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“…Through initial analysis, we determined that motion correction had minimal influence on pulsatility measurements in segmented vessels. However, future studies will characterize pulsatility measurements in the context of motion and aberration correction (Demené et al 2021, Xing et al 2023.…”

Section: Discussionmentioning

confidence: 99%

Quantitative pulsatility measurements using 3D dynamic ultrasound localization microscopy

Bourquin,

Porée,

Rauby

et al. 2024

Phys. Med. Biol.

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A rise in blood flow velocity variations (i.e., pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires brain-wide pulsatility measurements, with large penetration depth and high spatiotemporal resolution. The development of Dynamic Ultrasound Localization Microscopy (DULM), based on ULM, has enabled pulsatility measurements in the rodent brain in 2D. However, 2D imaging accesses only one slice of the brain and measures only 2D-projected and hence biased velocities . Herein, we present 3D DULM: using a single ultrasound scanner at high frame rate (1000-2000 Hz), this method can produce dynamic maps of microbubbles flowing in the bloodstream and extract quantitative pulsatility measurements in the cat brain with craniotomy and in the mouse brain through the skull, showing a wide range of flow hemodynamics in both large and small vessels. We highlighted a decrease in pulsatility along the vascular tree in the cat brain, which could be mapped with ultrasound down to a few tens of micrometers for the first time. We also performed an intra-animal validation of the method by showing consistent measurements between the two sides of the Willis circle in the mouse brain. Our study provides the first step towards a new biomarker that would allow the detection of dynamic abnormalities in microvessels in the brain, which could be linked to early signs of neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Quantitative pulsatility measurements using 3D dynamic ultrasound localization microscopy

Bourquin,

Porée,

Rauby

et al. 2024

Phys. Med. Biol.

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“…Aberrator #3 was an ex vivo temporal bone model with dimensions approximately 70 × 50 mm and a thickness of less than 4 mm. It had a density of 1450 mg/cm 3 .…”

Section: Equipment Used During the Experimental Testingmentioning

confidence: 99%

“…1,2 Aberrations affect the results of ultrasound diagnostics and treatment in various scenarios. Their negative effect is most pronounced at higher frequencies, that is, in applications such as ultrasound localization microscopy, 3 high resolution breast examinations, 4 imaging during pregnancy, and in obese patients, which, in 2016 represented at least 37.9% of the USA population. 5 Additionally, they are a major issue in transcranial ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Aberration correction by polynomial approximation for synthetic aperture ultrasound imaging

Leonov,

Kulberg,

Yakovleva

2024

Medical Physics

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BackgroundPreviously, there has been some work in the field of optical imaging on phase compensation by employing Legendre polynomials as an expansion of the phase function, and this seems to be an appealing unstudied area in the field of ultrasound imaging.PurposeThe paper is devoted to solving one of the problems of enhancing the authenticity of diagnostics data obtained in ultrasound visualization systems and presents a novel approach to aberration correction, which ensures a reliable eliminating of phase distortions. The novelty of the proposed approach consists in the use of the decomposition of the wave front by Legendre polynomials to approximate aberrations of the phase front of ultrasonic waves propagating through distorting layers.MethodsThe phase aberrations are corrected using a single sector probe that captures echoes in synthetic aperture mode. The proposed method approximates the changes in the wave front by means of the Legendre polynomials. The performance was investigated by placing a 13‐mm‐wide ultrasonic probe with 64 elements operating at 2 MHz on the surface of a commercial quality control phantom ATS Model 539 through a distorting layer. The following metrics were measured: peak value, root mean square (RMS), full width at half maximum (FWHM), contrast‐to‐noise ratio (CNR). During the experiments, three different aberrators were used interchangeably as distorting layers, two of which were made of photopolymer resin with RMS values of 39 and 97 ns and a speed of sound close to that of a human temporal bone tissue, and the third was an ex vivo human temporal bone with the RMS value of 44 ns. To test the correction, three regions inside the phantom were examined. Two‐sided nonparametric Wilcoxon rank‐sum test was used for assessing the statistical significance. The significance level for this study was set at α ≤ 0.05. To counteract the problem of multiple comparisons, the p‐values were adjusted by the Holm–Bonferroni correction method.ResultsThe statistically significant results have demonstrated the possibility of increasing peak intensity value up to 3.08 times, reducing the RMS width and FWHM of the intensity angular distribution down to 60% and 82%, respectively, and increasing CNR up to 2.12 times by using the proposed phase distortion correction method, compared with the case without correction. The results show that the method can be used as an effective aberration correction technique for all tested regions inside the phantom and distorting layers. Its usage allowed correcting up to 97% of the aberrations caused by the ex vivo temporal bone model.ConclusionThe results show that the usage of the proposed method for aberration correction can successfully increase the intensity and reduce the angular width of the ultrasound wave scattered by the point targets inside the phantoms. The method works with different distorting layers and is capable of correcting phase aberrations in multiple sections of the sonogram. The limitation of the proposed method consists in the fact that it requires the use of aperture synthesis and access to raw radiofrequency data, which restricts its application in common scanners.

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Dynamic Ultrasound Localization Microscopy Without ECG-Gating

Ghigo,

Ramos-Palacios,

Bourquin

et al. 2024

Ultrasound in Medicine & Biology

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Phase Aberration Correction for In Vivo Ultrasound Localization Microscopy Using a Spatiotemporal Complex-Valued Neural Network

Cited by 5 publications

References 50 publications

Quantitative pulsatility measurements using 3D dynamic ultrasound localization microscopy

Quantitative pulsatility measurements using 3D dynamic ultrasound localization microscopy

Aberration correction by polynomial approximation for synthetic aperture ultrasound imaging

Dynamic Ultrasound Localization Microscopy Without ECG-Gating

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