“…The only agent currently approved by the US Food and Drug Administration (FDA) that inhibits PI3K is idelalisib (Gilead), a specific p110δ inhibitor that is approved for the treatment of relapsed follicular lymphoma, chronic lymphocytic leukaemia (CLL), or small lymphocytic lymphoma (SLL) (Lannutti et al , ; Furman et al , ). Other agents, however, including the pan class‐I PI3K inhibitors buparlisib (Novartis), pilaralisib (Exelixis/Sanofi) and copanlisib (Bayer), have been used with some limited success in B‐NHL, including DLBCL, with response rates in the 10‐20% range (Table ) (Dreyling et al , ; Younes et al , ; Brown et al , ). There is very little, if any, experience with PI3K inhibition in BL.…”