2012
DOI: 10.1097/fpc.0b013e32834aeedb
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Cited by 74 publications
(37 citation statements)
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References 35 publications
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“…Genotyping CYP2C9 and VKORC1 aid in the management of patients receiving warfarin therapy [9,10]. CYP2C19 is important for the metabolism of a number of drugs including clopidogrel, omeprazole and phenytoin [1113]. CYP3A5 is associated with the metabolism of tacrolimus [14].…”
Section: Introductionmentioning
confidence: 99%
“…Genotyping CYP2C9 and VKORC1 aid in the management of patients receiving warfarin therapy [9,10]. CYP2C19 is important for the metabolism of a number of drugs including clopidogrel, omeprazole and phenytoin [1113]. CYP3A5 is associated with the metabolism of tacrolimus [14].…”
Section: Introductionmentioning
confidence: 99%
“…The dihydrodiol can be converted into catechol or conjugated with glucuronide. Less than 5% of the administered dose of PHT is excreted unchanged in urine [1,2,3,4]. …”
Section: Introductionmentioning
confidence: 99%
“…However, individuals that carry at least one mutated allele have a decrease in the enzyme activity. Those who are heterozygous, carrying one wild-type allele and one mutant allele ( *1/*2 or *1/*3 ) have a mild-to-moderate decrease in the enzyme activity and are classified as IM, whereas the individuals that are homozygous carrying two mutant alleles ( *2/*2 , *2/*3 or *3/*3 ) have a significant decrease in the enzyme activity and are classified as PM [1,16]. …”
Section: Introductionmentioning
confidence: 99%
“…Ethnic distributions of the CYP2C9 polymorphisms are clinically significant in anticoagulation therapy because CYP2C9 is the major P450 that inactivates the active S -enantiomer of warfarin 6 . CYP2C19 catalyzes the metabolism of many commonly used drugs, including omeprazole 11 , phenytoin 12 , and diazepam 13 . Most poor metabolization of CYP2C19 is attributable to the CYP2C19*2 and *3 alleles.…”
Section: Introductionmentioning
confidence: 99%