Pharmakologische Wirkungen des Darmstoffs

Kuck, H; Vogt, W.

doi:10.1007/bf00247630

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…The incubation medium consisted of a balanced salt solution (Ringer's solution) also containing 7 mM glucose, 0.75 mM L-glutamine, 10 mM 3-aminotriazole (AT) and 1 mg% each of potassium penicillin G and streptomycin sulfate. The function of 3-aminotriazole in these experiments is to inhibit catalase resulting in a decreased concentration of glutathione in the lens (Kuck, 1976). It does not absorb light at the wavelengths used in these experiments and does not act as a photosensitizer.…”

Section: Methodsmentioning

confidence: 99%

Ultraviolet Action Spectrum for Fluorogen Production in the Ocular Lens

Borkman

Dalrymple

Lerman

1977

Photochem & Photobiology

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Previous work has demonstrated that fluorescent material (360 nm excitation, 440 nm emission), whose concentration normally increases with age in human lenses, can be generated artificially by exposing cultured human or animal lenses to UV radiation. In the present paper we report measurements of the rate of production of this fluorescent material in rat lenses in uitro as a function of UV irradiation wavelength. A plot of the observed rate of fluorogen production normalized to constant photon flux vs irradiation wavelength shows little action at 360 or 320 nm, increases sharply at 300 nm, remains relatively constant in the range 300-280nm, and then exhibits a further gradual rise from 270-25Onm. The results on rat lenses are compared with results reported elsewhere for tryptophan in aqueous solution. The action spectrum for photochemical destruction of tryptophan in solution closely parallels that for fluorogen production in rat lenses. This result and other evidence suggest that photochemical destruction of tryptophan might be the initial event in UV-induced fluorogen production in the ocular lens.

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Section: Methodsmentioning

confidence: 99%

Ultraviolet Action Spectrum for Fluorogen Production in the Ocular Lens

Borkman

Dalrymple

Lerman

1977

Photochem & Photobiology

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“…The major components of both the isolated by hot alkali treatment of horse intestine horse intestine and rabbit kidney phospholipid excontracted in vitro preparations of visceral smooth tracts were shown by Wiley, Summer & Walaszek muscle similarly to an unknown substance which he (1970) to be phosphorylated glyceryl acetals of palhad observed in the bath fluid of isolated frog intesmitaldehyde, olealdehyde and linolealdehyde; the tine and which he called 'Darmstoff' (Vogt, 1949; structures were confirmed by synthesis, and the Kuck & Vogt, 1950). A phospholipid substance exolealdehyde derivative was shown to elicit contractracted from rabbit kidney under less rigorous conditions of the guinea-pig ileum identical to those of the tions also contracted visceral smooth muscle (Dyer & natural phospholipid mixture.…”

Section: Introductionmentioning

confidence: 91%

Acetal phosphatidic acids: novel platelet aggregating agents

Brammer

Maguire

Walaszek

et al. 1983

British J Pharmacology

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1 Pahmitaldehyde, olealdehyde and linolealdehyde acetal phosphatidic acids induced rapid shape change and dose-dependent biphasic aggregation of human platelets in platelet-rich plasma; aggregation was reversible at low doses and irreversible at high doses of the acetal phosphatidic acids. The palmitaldehyde congener elicited monophasic dose-dependent aggregation of sheep platelets in platelet-rich plasma. 4 The adenosine diphosphate (ADP) antagonist, 2-methylthio-AMP, and the cyclo-oxygenase inhibitor, aspirin, abolished PGAP-induced second phase aggregation and release in human platelets but did not affect the first, reversible, phase of aggregation. Both the first and second phases of PGAP-induced aggregation were abolished by chlorpromazine, by the phospholipase A2 inhibitor, mepacrine, and by nmolar concentrations of prostaglandin E1 (PGEI); these agents abolished the second, but not the first phase of ADP-induced aggregation.5 The related phospholipids, lecithin, lysolecithin and phosphatidic acid, at < 100 tM, neither induced aggregation of human platelets in platelet-rich plasma, nor modified PGAP-induced aggregation; 1-palmityl lysophosphatidic acid elicited aggregation of human platelets at a threshold concentration of 100 jIM. 6 It is concluded that the acetal phosphatidic acids induce platelet aggregation per se by direct action at the platelet membrane, and that the acetal function is of primary importance in their potent platelet-stimulating activity. Moreover, as the acetal phosphatidic acids are the major components of the smooth muscle-contracting acidic phospholipid tissue extract 'Darmstoff' (Vogt, 1949), their potent platelet-aggregating properties may be of physiological or pathological significance.

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“…Sensitization to musclestimulating substances may be a common property of lipid-soluble slow contracting acidic substances. For instance, Darmstoff, a phosphatidic acid, has this effect (Kuck & Vogt, 1950).…”

Section: Discussionmentioning

confidence: 99%

Pharmacologically active substances formed in egg yolk by cobra venom

Vogt¹

1957

The Journal of Physiology

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Pharmakologische Wirkungen des Darmstoffs

Cited by 6 publications

References 4 publications

Ultraviolet Action Spectrum for Fluorogen Production in the Ocular Lens

Ultraviolet Action Spectrum for Fluorogen Production in the Ocular Lens

Acetal phosphatidic acids: novel platelet aggregating agents

Pharmacologically active substances formed in egg yolk by cobra venom

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