Pharmakologische Studien an Seeigeleiern

Fühner, H.

doi:10.1007/bf01837799

Cited by 20 publications

(6 citation statements)

References 1 publication

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“…1, and they are summarized in Table 1. Decrease in I50 of Cl, C2, and C3 alcohol followed a progression about 1, 1/3, and (1/3)2, respectively, as had been pointed out by Fuhner (2). Among alcohols with the same number of carbons, primary alcohols were more inhibitory than secondary alcohols (e.g., C4 and C8), secondary alcohols were more inhibitory than tertiary alcohols (e.g., C4), and aliphatic alcohols were more inhibitory than aromatic alcohols (e.g., C7 and C8).…”

Section: Resultssupporting

confidence: 68%

Inhibition of Bacillus subtilis spore germination by various hydrophobic compounds: demonstration of hydrophobic character of the L-alanine receptor site

Yasuda-Yasaki¹,

Namiki-Kanie²,

Hachisuka³

1978

J Bacteriol

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L-Alanine-initiated germination of Bacillus subtilis spores was inhibited by various kinds of hydrophobic compounds. Good correlation of inhibitory effect with hydrophobicity of the compound was demonstrated by using regression analysis in which the hydrophobic character was expressed by the partition coefficient in an octyl alcohol-water system. The correlation coefficient for 20 alcohols was 0.959, and that for 19 miscellaneous compounds was 0.906. Regression lines of the alcohols and other hydrophobic compounds were almost identical, showing that hydrophobic interaction played an important role in inhibition. Diphenylamine was one of the most effective inhibitors examined. n-Octyl, nnonyl, and n-decyl alcohols were the most effective alcohols. The mode of inhibition by diphenylamine and n-octyl alcohol was a "mixed type" (competitive plus noncompetitive type) with respect to L-alanine; that by D-alanine was competitive inhibition. Sites for diphenylamine, n-octyl alcohol, and D-alanine may have overlapped. Inhibition was reversible by washing; heat resistance, stainability, and germination rate of the washed spores remained unaltered. Thus, we confirm that the inhibition may occur before the initial trigger reaction of germination and that it may be due to the interaction between a hydrophobic compound and a hydrophobic region closely associated with the L-alanine receptor site on the spore.

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Section: Resultssupporting

confidence: 68%

Inhibition of Bacillus subtilis spore germination by various hydrophobic compounds: demonstration of hydrophobic character of the L-alanine receptor site

Yasuda-Yasaki¹,

Namiki-Kanie²,

Hachisuka³

1978

J Bacteriol

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“…The density function set R is the source of all the information one can extract from every one of the CS molecular structures. The relevant CS information for QQSPR purposes can be obtained from R by means of a QQSPR Hermitian operator X to be determined, a known positive definite operator W and the expectation value integral (9). Within the QQSPR framework, the Hermitian QQSPR operator, X, can be constructed using a first order approach as:…”

Section: Qqspr Fundamental Equationmentioning

confidence: 99%

“…(15), with the aid of the quantum self-similarity empirical relationships, 8 a new simplified fundamental QQSPR equation:…”

Section: Qqspr Simplified Fundamental Equation and Number Of Atoms Inmentioning

confidence: 99%

“…(1) higher powers of the atomic number, perhaps before using any other descriptor, a second or third order polynomial (in N I ) models can be easily tested in eq. (8).…”

Section: Atom Number Correction Parameters and Quantummentioning

confidence: 99%

“…[2][3][4][5][6][7] But the previous quoted work, which has triggered the present note, is far from to be unique within the QSPR literature. For instance, the relationships between number of carbon atoms and narcotic action of several molecules can be found printed as earlier as 1904, [8][9][10] while other articles, including number of atoms as molecular descriptors appeared also before the quoted ones, like references 11 and 12. Also, the use of molecular weight, an obvious function of the number of atoms, as a descriptor in a 2000 paper 13 and in very recent ones, 14,15 can be also quoted as items related to the general purpose of the present study.…”

Section: Introductionmentioning

confidence: 99%

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Notes on quantitative structure‐properties relationships (QSPR) part 2: The role of the number of atoms as a molecular descriptor

Carbó‐Dorca

Gallegos

2009

J Comput Chem

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A previous analysis performed in our laboratory about the polynomial dependency of the atomic quantum self-similarity measures on the atomic number, together with recent publications on quantitative structure-properties relationships (QSPR), based on the number of molecular atoms, published by various authors, have driven us to show here that a simplified form of the fundamental quantum QSPR (QQSPR) equation, permits to theoretically demonstrate the important, but obvious, role of the number of atoms in a molecule, as a possible molecular descriptor. A discussion of the practical use of the number of atoms in QSPR is also given at the end, which also contains a discussion on the role of Ockham's razor in descriptor simplification choices.

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The physical toxicity of chemicals. II. Factors affecting physical toxicity in aqueous solutions

McGowan¹

1952

J. Appl. Chem.

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Evidence has been brought forward to show that a large number of simple organic compounds produce toxic symptoms in living organisms when they reach a definite concentration in some biophase. If this is so, for non‐associated compounds which do not participate in hydrogen‐bonding the equation — log10Ct = – log10C′ + k[P] is suggested by considerations of solubility. Here, Ct and C′ are the toxic concentrations in water and in the biophase respectively (g.‐mol./1.); [P] is the parachor (c.c.) and k is a constant. This equation was found to hold and examples are given. The constant k has been found to have the value o·012 and C′ is, of course, constant for any one manifestation of toxicity. Corrections can be applied for the presence in the molecules of the toxic compounds of groupings giving rise to association and hydrogen bonding. The equation is useful for the prediction of toxicities of compounds which would be expected to be physically toxic and for the classification of data on toxicities of aqueous solutions.

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Pharmakologische Studien an Seeigeleiern

Cited by 20 publications

References 1 publication

Inhibition of Bacillus subtilis spore germination by various hydrophobic compounds: demonstration of hydrophobic character of the L-alanine receptor site

Inhibition of Bacillus subtilis spore germination by various hydrophobic compounds: demonstration of hydrophobic character of the L-alanine receptor site

Notes on quantitative structure‐properties relationships (QSPR) part 2: The role of the number of atoms as a molecular descriptor

The physical toxicity of chemicals. II. Factors affecting physical toxicity in aqueous solutions

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