Despite government efforts to increase health care insurance and access in China, many individuals, regardless of insurance status, continue to engage in high levels of self-medication. To understand the factors influencing common self-medication behaviour in a community of food market venders in Fuzhou China, a total of 30 market venders were randomly recruited from six food markets in 2007. In-depth interviews were conducted with each participant at their market stalls by trained interviewers using a semi-structured open-ended interview protocol. Participants were asked broad questions about their health-seeking behaviours as well as their past experiences with self-medication and hospital care. ATLAS.ti was used to manage and analyze the interview data. The results showed that hospital-based health care services were perceived as better quality. However, self-medication was viewed as more affordable in terms of money and time. Other factors prompting self-medication included confidence in understanding the health problem, the easy accessibility of local pharmacies, and the influences of friends/peers and advertising. Three broad domains, attitude, cost, and effectiveness, were all seen to determine past decisions and experiences with self-medication. Interestingly, the effective management of self-medication via pharmacy resources raised particular concern because of perceived variation in quality. In conclusion, self-medication was found to be an important and common health-seeking behaviour driven by multiple factors. A sound and comprehensive public health system should systematically attend to these behaviours and the pharmacies where much of the behaviour occurs.