Pharmacy Infection Control: Basic Hygiene for Pharmacy Staff

Alomi, Yousef Ahmed; Alyousef, Anhar; Islam, Mohammed Mominul; Almadany, Maha Hussein; Almana, Fatimah Abdaziz; Badawoud, Ebtissam Mohammad; Khurshid, Fahad

doi:10.5530/ptb.2022.8.7

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ischemic stroke, Hemorrhagic stroke, Cerebrovascular accident (CVA) and Transient Ischemic attack (TIA). Special Personnel protective equipment (PPE) was used for the assessment of stroke patients data admitted in isolation wards [ 20 , 21 ]. Patients from both sexes were included and classified into two categories as adults and geriatrics and patients having a total hospital stay length of fewer than 30 days were included in this study.…”

Section: Methodsmentioning

confidence: 99%

A prospective observational study of estimating drug related problems and clinical outcomes in subtypes of stroke patients

Ali,

Shoaib,

Nesar

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Stroke is a neurological disease and a leading cause of mortality worldwide. Strokes mainly consist of two types: hemorrhage and ischemia. Stroke patients are being administered multiple drug therapy and are at risk of drug-related problems. Aim To estimate drug-related problems (DRPs) and clinical end outcomes in hospitalized stroke patients. Methods Current study was a multicenter, cross-sectional prospective observational study including 250 stroke patients admitted to tertiary care hospitals in Karachi, Pakistan. The study included all clinical subtypes of stroke patients i.e. Stroke, Ischemic stroke, Hemorrhagic stroke, CVA, and TIA. Associations among patient-clinical end outcomes and drug therapy-related variables like DRPs, mortality, and morbidity rates were estimated using Pearson’s chi-squared test. Statistical analysis was done by using SPSS software, version 25. Results A total of 250 patients participated in this study suffering from different clinical subtypes of stroke i.e. Ischemic stroke, hemorrhagic stroke, TIA, and CVA, including 46% male and 54% female patients. The majority of patients’ stay at the hospital was between 1–10 days. The overall mortality rate in stroke patients was 51%. HAIs were observed in 70% of patients, HAIs faced by patients were SAP, CAP, UTI, sepsis, and VAP. Drugs were assessed according to NEML i.e. access group antibiotics, watch group antibiotics, reserve group antibiotics, statins, antiepileptics, and proton pump inhibitors. Majorly ceftriaxone was administered to 79% of patients, piperacillin-tazobactam to 52%, and cefixime to 48%, whereas meropenem was administered to 42% of patients along with vancomycin to 39% of total patients. A high mortality rate was observed in the case of Klebsiella pneumoniae and Staphylococcus aureus i.e. 78% and in the case of streptococcus pneumoniae 61% mortality rate was observed. Due to the presence of DRPs and various other clinical factors like comorbidities, DDIs, HAIs, administration of potentially nephrotoxic drugs, and administration of antibiotics without having CST, hospitalized stroke patients faced many problems. Conclusion This study helped determine DRPs along with various clinical factors affecting the clinical end outcomes of patients suffering from any clinical subtype of stroke. Due to the enhancement in the evidence of the incidence of DRPs in tertiary care hospitals, pharmacist-led drug therapy review by interfering with doctors and other medical professionals at the patient bed site is needed and should be done to avoid any negative end outcomes and serious issues related to DRPs.

show abstract

Section: Methodsmentioning

confidence: 99%

A prospective observational study of estimating drug related problems and clinical outcomes in subtypes of stroke patients

Ali,

Shoaib,

Nesar

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Patients admitted in the neurology ward, medical ward, surgical or medical ICU, and isolation ward suffering from BM. Special Personnel protective equipment (PPE) was used for the assessment of BM patients data admitted in isolation wards [ 28 , 29 ] Patients from both genders were included and classified as paediatrics (01 to 12 years), adults (18 to 65 years), and geriatrics (66 to 75 years), and patients having a total length of hospital stay less than 01 months were included.…”

Section: Methodsmentioning

confidence: 99%

Assessment of potential drug-related problems (PDRP) and clinical outcomes in bacterial meningitis patients admitted to tertiary care hospitals

Ali,

Shoaib,

Nesar

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Meningitis is an important cause of morbidity and mortality in children and adults. Its treatment strategy varies with age and gender. To assess potential drug-related problems (PDRP) and clinical outcomes in bacterial meningitis patients, a multicenter, clinical, descriptive, cross-sectional prospective observational study in 120 patients admitted to different tertiary care hospitals in Karachi was conducted. It includes both males 48% and females 52% belonging from all age groups i.e. peadiatrics (01 to 12 years), adults (18 to 65 years), and geriatrics (66 to 75 years). Out of these 72 patients were admitted in the public sector and 48 patients were admitted in private sector hospitals. Nosocomial infections were developed in 41% of patients during their stay at the hospital. Potentially nephrotoxic drugs were administered to all BM patients, these drugs should be administered carefully. Majorly Ceftriaxone was administered to 86% of patients, Vancomycin 71%, and meropenem 73% whereas 68% of patients were administered piperacillin-tazobactam. Organisms involved as causative agents in the majority of patients are Neisseria meningitides, Pseudomonas aeruginosa and, Streptococcus pneumoniae. DRPs impacted patient clinical outcomes in presence of many other factors like comorbidities, DDIs, Nis, administration of potentially nephrotoxic drugs, and administration of watch group and reserve group antibiotics without having culture sensitivity test, even after having CST no principles of de-escalation for antibiotics were done, which is a very important factor for hospitalized patients having IV antibiotics. The mortality rate among BM patients was 66%. The majority of patients (87%) stay at the hospital was 1–10 days. The present study helped in the identification of DRPs along with some other factors affecting the clinical outcomes in patients suffering from bacterial meningitis. Healthcare professionals should receive awareness and education on the importance of CST before initiating antibiotic therapy. Pharmacist-led medication review is necessary and should be followed to avoid negative outcomes and serious consequences related to DRPs.

show abstract

Pharmacy Infection Control: Basic Hygiene for Pharmacy Staff

Cited by 2 publications

References 23 publications

A prospective observational study of estimating drug related problems and clinical outcomes in subtypes of stroke patients

A prospective observational study of estimating drug related problems and clinical outcomes in subtypes of stroke patients

Assessment of potential drug-related problems (PDRP) and clinical outcomes in bacterial meningitis patients admitted to tertiary care hospitals

Contact Info

Product

Resources

About