Pharmacotherapy Regimens Among Patients With Posttraumatic Stress Disorder and Mild Traumatic Brain Injury

Morgan, Meghan; Lockwood, Anna; Steinke, Doug; Schleenbaker, Randal E.; Botts, Sheila

doi:10.1176/appi.ps.201000531

Cited by 23 publications

(21 citation statements)

References 8 publications

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“…Post traumatic stress disorder (PTSD) is highly prevalent among active-duty U.S. military service members returning from combat deployments in Iraq and Afghanistan (1). Although a variety of psychotropic medications are used to treat PTSD symptoms in these service members (2), the medications' efficacy and adverse effects in this population remain to be determined in controlled trials. In the absence of such trials, treatment guidelines for active-duty service members rely heavily on PTSD trials in civilian samples (3).…”

mentioning

confidence: 99%

A Trial of Prazosin for Combat Trauma PTSD With Nightmares in Active-Duty Soldiers Returned From Iraq and Afghanistan

Raskind

Peterson

Williams

et al. 2013

AJP

288

211

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mentioning

confidence: 99%

A Trial of Prazosin for Combat Trauma PTSD With Nightmares in Active-Duty Soldiers Returned From Iraq and Afghanistan

Raskind

Peterson

Williams

et al. 2013

AJP

288

211

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“…While antidepressants can be useful in managing some of the symptoms of TBI, the prescribing of benzodiazepines to those with TBI can impede function or be dangerous (94,102,103). Of note, antipsychotics have been shown to impede recovery or be dangerous in clinical studies and animal models of TBI (104,105).…”

Section: The Single Most Common Biological Cause Of Psychiatric Symptomsmentioning

confidence: 99%

“…For example, 41% of veterans with PTSD were prescribed benzodiazepines, while those with both PTSD and TBI had a 67% chance of being prescribed a benzodiazepine. Similarly, antipsychotics were prescribed to 25% of veterans with PTSD, but 40% of those with both PTSD and TBI (103). Other treatments for PTSD, such as transcranial magnetic stimulation, can be dangerous in TBI due to induction of seizures (106).…”

Section: The Single Most Common Biological Cause Of Psychiatric Symptomsmentioning

confidence: 99%

Functional Neuroimaging in Psychiatry—Aiding in Diagnosis and Guiding Treatment. What the American Psychiatric Association Does Not Know

et al. 2020

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“…Inappropriate prescriptions [97][98][99][100] and potential prescription omissions [98] have also been documented. Moreover, multiple medications are frequently used in patients with PTSD and traumatic brain injury [101,102], as well as in the management of chronic pain [103][104][105][106].…”

Section: Dietary Supplements and Nutraceuticals: Friends Or Foes?mentioning

confidence: 99%

Nutraceutical-based Integrative Medicine: Adopting a Mediterranean Diet Pyramid for Attaining Healthy Ageing in Veterans with Disabilities

Ciccotti¹,

Raguzzini

Sciarra³

et al. 2019

CPD

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Veterans with disability represent a big burden worldwide and often require long-term rehabilitation. Unhealthy dietary and lifestyle habits, including smoke and alcohol abuse, are common in veterans. In the context of integrative medicine approaches, the "complementary and alternative medicine" has been suggested for the management of chronic diseases. However, the potential risk of interaction between herbal products, dietary supplements and drugs must be considered in veterans. The Mediterranean diet has been suggested as a natural, non-pharmacological nutraceutical for healthy ageing. Although there is a broad consensus on the positive effect of plant foods consumption, the presence of glucosinolates, flavonoids and furanocoumarins in some plant foods and beverages must be taken into consideration owing to their potential interfering with drugs metabolism and bioavailability. Albeit seasonality could ensure the maintenance of the single dose of phytochemical below that at which adverse effects in some individuals genetically predisposed or unpleasant drug interactions in diseased subjects can occur, a personalized nutrition is recommended in veterans who are under treatment for comorbidities. Furthermore, sports practice can lead veterans with motor disabilities and mental impairments to excel in some disciplines, giving rise to the phenomenon of the Paralympics and the development of "recreational therapy". Moreover, outdoor lifestyle, through vitamin D synthesis, and conviviality, improving socialization, could account for the Mediterranean lifestyle health benefits. In this work, we propose for veterans a Mediterranean Pyramid, which could be the basis for integrative medicine for veterans with disabilities, patient-centered approaches and interprofessional (including physical medicine and rehabilitation clinicians, pharmacists and nutritionists) interventions.

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Pharmacotherapy Regimens Among Patients With Posttraumatic Stress Disorder and Mild Traumatic Brain Injury

Abstract: The differences in drug therapy found in this study may indicate that patients with TBI and PTSD respond differently to treatment than patients with PTSD alone.

Cited by 23 publications

References 8 publications

A Trial of Prazosin for Combat Trauma PTSD With Nightmares in Active-Duty Soldiers Returned From Iraq and Afghanistan

A Trial of Prazosin for Combat Trauma PTSD With Nightmares in Active-Duty Soldiers Returned From Iraq and Afghanistan

Functional Neuroimaging in Psychiatry—Aiding in Diagnosis and Guiding Treatment. What the American Psychiatric Association Does Not Know

Nutraceutical-based Integrative Medicine: Adopting a Mediterranean Diet Pyramid for Attaining Healthy Ageing in Veterans with Disabilities

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