Pharmacotherapy of anxiety disorders in patients with chronic cerebral ischemia

Воробьева, О. В.; Rusaya, V V

doi:10.17116/jnevro201611612249-54

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…However, adjustments of doses were complex and needed further investigations. In addition, GABA enhancer treatments, such as rac-hopantenic acid (pantogam activ) [102, 103] and adaptol [104], remarkably improved psychopathological, psychometric, and detailed somatic functions (e.g., cognitive functions, but also emotional state) with reduced adverse events (e.g., drowsiness and headaches) in patients with chronic cerebral ischemia. Therefore, developing new drugs of GABA enhancers with less adverse effects may be the next focus of clinical studies.…”

Section: The Role Of Gaba In Cerebral I/r Injury In Adultmentioning

confidence: 99%

The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

Chen

Zhou

Jian

et al. 2019

Oxidative Medicine and Cellular Longevity

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Ischemia-reperfusion (I/R) injury is a common pathological process, which may lead to dysfunctions and failures of multiple organs. A flawless medical way of endogenous therapeutic target can illuminate accurate clinical applications. γ-Aminobutyric acid (GABA) has been known as a marker in I/R injury of the central nervous system (mainly in the brain) for a long time, and it may play a vital role in the occurrence of I/R injury. It has been observed that throughout cerebral I/R, levels, syntheses, releases, metabolisms, receptors, and transmissions of GABA undergo complex pathological variations. Scientists have investigated the GABAergic enhancers for attenuating cerebral I/R injury; however, discussions on existing problems and mechanisms of available drugs were seldom carried out so far. Therefore, this review would summarize the process of pathological variations in the GABA system under cerebral I/R injury and will cover corresponding probable issues and mechanisms in using GABA-related drugs to illuminate the concern about clinical illness for accurately preventing cerebral I/R injury. In addition, the study will summarize the increasing GABA signals that can prevent I/R injuries occurring in peripheral organs, and the roles of GABA were also discussed correspondingly.

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Section: The Role Of Gaba In Cerebral I/r Injury In Adultmentioning

confidence: 99%

The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

Chen

Zhou

Jian

et al. 2019

Oxidative Medicine and Cellular Longevity

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Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports

et al. 2020

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Phenibut is a nootropic drug that exerts anxiolytic and antinociceptive effects by acting on the GABAB receptor and the α2-δ subunit of voltage-dependent calcium channels. An increased number of reports of dependence to and intoxication by phenibut purchased online on the one hand and the wide prescription of phenibut in Eastern Europe for more than half a century on the other hand have resulted in a number of controversies regarding its use. In this review, we have summarized currently available information from case reports of phenibut dependence and intoxication and safety data from clinical trials. We included 14 dependence and intoxication case reports (16 patients) and reviewed 11 phenibut clinical trials (583 patients). The clinical symptoms in the case reports included cardiovascular effects, insomnia, anxiety and agitation, hallucinations, and depressed level of consciousness. In addition, the doses used (0.5–100 g/day) were much higher than the recommended daily dose (0.25–2 g/day). An analysis of phenibut side effects described in the clinical trials showed adverse events in only 5.66% of patients, and the most reported side effect was somnolence (1.89%). There are discrepancies in the reported side effects of phenibut in clinical trials compared to those reported in cases of online-purchased phenibut dependence and intoxication. The current systematic review provides evidence that, at therapeutic doses, phenibut is safe and well tolerated with minor adverse effects, but questions regarding the quality of phenibut obtained online and the contribution of alcohol and other drug abuse to phenibut dependence and intoxication remain open.

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Mortality from Acute and Chronic Diseases of the Circulatory System in the Period before and after the COVID-19 Pandemic in Moscow

Semenova,

Grigorov,

Sabgaida

2024

DEMIS. Demographic Research

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Sudden death from acute forms of cardiovascular diseases, especially in working age, when it is physiologically clearly premature, is evidence of diseases not detected in time: the main task of cardiologists is to avoid the transition of chronic pathologies into an acute form, in which the condition can worsen at lightning speed. Acute and chronic forms of cardiovascular diseases require different clinical approaches. Thus, the division of pathologies into two blocks– acute and chronic conditions– has, in addition to academic, purely practical significance. In this context, the specifics of the metropolis, with its developed medical structure, both emergency and hospital, and outpatient, are extremely interesting. The present study is devoted to identifying differences in the dynamics of acute and chronic forms of circulatory diseases during stable and crisis periods in a metropolis. It demonstrated that the contribution of acute conditions to both mortality from coronary heart disease and CVB, as well as losses from diseases of the circulatory system in general, decreased significantly in the population of Moscow during the study period, which certainly indicates positive changes in mortality. Similar processes were observed in Russia, but in Moscow the proportion of acute conditions was lower than the national one.

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Pharmacotherapy of anxiety disorders in patients with chronic cerebral ischemia

Cited by 4 publications

References 8 publications

The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

The Roles of GABA in Ischemia-Reperfusion Injury in the Central Nervous System and Peripheral Organs

Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports

Mortality from Acute and Chronic Diseases of the Circulatory System in the Period before and after the COVID-19 Pandemic in Moscow

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