Pharmacotherapy of acute and chronic hearing loss

Hesse, Gerhard; Laubert, A.

doi:10.1007/s00106-010-2179-6

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…In case of acute tinnitus manifestation, existing treatment options may be considered unsatisfactory. On the one hand, several pharmacological approaches (Patterson and Balough, 2006 ) have been established considering tinnitus to be equivalent to sudden sensorineural hearing loss (Hesse and Laubert, 2010 ) or to any cochlear damage (Shim et al, 2011 ). However, none of these treatment methods have proven to be effective after replication in controlled trials (Elgoyhen and Langguth, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy

Krick

Grapp²,

Daneshvar-Talebi

et al. 2015

Front. Neurosci.

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Pathophysiology and treatment of tinnitus still are fields of intensive research. The neuroscientifically motivated Heidelberg Model of Music Therapy, previously developed by the German Center for Music Therapy Research, Heidelberg, Germany, was applied to explore its effects on individual distress and on brain structures. This therapy is a compact and fast application of nine consecutive 50-min sessions of individualized therapy implemented over 1 week. Clinical improvement and long-term effects over several years have previously been published. However, the underlying neural basis of the therapy's success has not yet been explored. In the current study, the therapy was applied to acute tinnitus patients (TG) and healthy active controls (AC). Non-treated patients were also included as passive controls (PTC). As predicted, the therapeutic intervention led to a significant decrease of tinnitus-related distress in TG compared to PTC. Before and after the study week, high-resolution MRT scans were obtained for each subject. Assessment by repeated measures design for several groups (Two-Way ANOVA) revealed structural gray matter (GM) increase in TG compared to PTC, comprising clusters in precuneus, medial superior frontal areas, and in the auditory cortex. This pattern was further applied as mask for general GM changes as induced by the therapy week. The therapy-like procedure in AC also elicited similar GM increases in precuneus and frontal regions. Comparison between structural effects in TG vs. AC was calculated within the mask for general GM changes to obtain specific effects in tinnitus patients, yielding GM increase in right Heschl's gyrus, right Rolandic operculum, and medial superior frontal regions. In line with recent findings on the crucial role of the auditory cortex in maintaining tinnitus-related distress, a causative relation between the therapy-related GM alterations in auditory areas and the long-lasting therapy effects can be assumed.

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Section: Introductionmentioning

confidence: 99%

Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy

Krick

Grapp²,

Daneshvar-Talebi

et al. 2015

Front. Neurosci.

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“…A number of therapy options have been developed for tinnitus treatment, comprising Tinnitus Retraining Therapy, Cognitive Behavioral Therapy, Progressive Tinnitus Management, Biofeedback, Education, and Relaxation Therapies (Herraiz et al, 2007 ; Hesse and Laubert, 2010 ; Hesser et al, 2011 ; Folmer et al, 2014 ; Grewal et al, 2014 ; Myers et al, 2014 ). Most therapies aim to dissuade patients auditory self-monitoring.…”

Section: Introductionmentioning

confidence: 99%

Heidelberg Neuro-Music Therapy Restores Attention-Related Activity in the Angular Gyrus in Chronic Tinnitus Patients

Krick

Argstatter²,

Grapp³

et al. 2017

Front. Neurosci.

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Background: Tinnitus is the perception of a phantom sound without external acoustic stimulation. Recent tinnitus research suggests a relationship between attention processes and tinnitus-related distress. It has been found that too much focus on tinnitus comes at the expense of the visual domain. The angular gyrus (AG) seems to play a crucial role in switching attention to the most salient stimulus. This study aims to evaluate the involvement of the AG during visual attention tasks in tinnitus sufferers treated with Heidelberg Neuro-Music Therapy (HNMT), an intervention that has been shown to reduce tinnitus-related distress.Methods: Thirty-three patients with chronic tinnitus, 45 patients with recent-onset tinnitus, and 35 healthy controls were tested. A fraction of these (21/21/22) were treated with the “compact” version of the HNMT lasting 1 week with intense treatments, while non-treated participants were included as passive controls. Visual attention was evaluated during functional Magnet-Resonance Imaging (fMRI) by a visual Continous Performance Task (CPT) using letter-based alarm cues (“O” and “X”) appearing in a sequence of neutral letters, “A” through “H.” Participants were instructed to respond via button press only if the letter “O” was followed by the letter “X” (GO condition), but not to respond if a neutral letter appeared instead (NOGO condition). All participants underwent two fMRI sessions, before and after a 1-week study period.Results: The CPT results revealed a relationship between error rates and tinnitus duration at baseline whereby the occurrence of erroneous “GO omissions” and the reaction time increased with tinnitus duration. Patients with chronic tinnitus who were treated with HNMT had decreasing error rates (fewer GO omissions) compared to treated recent-onset patients. fMRI analyses confirmed greater activation of the AG during CPT in chronic patients after HNMT treatment compared to treated recent-onset patients.Conclusions: Our findings suggest that HNMT treatment helps shift the attention from the auditory phantom percept toward visual cues in chronic tinnitus patients and that this shift in attention may involve the AG.

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“…Its prevalence rate is estimated to be about 10% to 15% of the general population (Hall et al, 2011). In Germany, about three million people suffer from tinnitus, and this number is rising by 235,000 annually (Hesse & Laubert, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…To date, there are several treatment options for patients with recent-onset tinnitus. Pharmacological approaches have been established equating tinnitus with sudden sensorineural hearing loss (Hesse & Laubert, 2010) or with any cochlear damage (Shim, Song, Choi, Lee, & Yoon, 2011). However, none of these treatment modalities has yet shown repeated efficacy in controlled trials (Elgoyhen & Langguth, 2011).…”

Section: Introductionmentioning

confidence: 99%

Neuro-Music Therapy for Recent-Onset Tinnitus

Grapp¹,

Hutter²,

Argstatter³

et al. 2013

Sage Open

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The aim of this pilot study was the evaluation of the neuro-music therapy approach as a new treatment option for patients with recent-onset tinnitus whose tinnitus symptoms were enduring after initial pharmacological treatment. In all, 15 patients with recent-onset tinnitus took part in our manualized short-term music-therapeutic treatment. Tinnitus severity and individual tinnitus distress were assessed by the German version of the tinnitus questionnaire (TQ) and the Attention and Performance Self-Assessment Scale (APSA) at three different measurement times: baseline (T 0 ), start of treatment (T 1 ), and end of treatment (T 2 ). Score changes in TQ and APSA from start to end of treatment indicated significant improvements in tinnitus-related distress. According to the Jacobson and Truax reliable change index (RC), 73.3% of the patients showed a reliable reduction in individual TQ-score. The neuro-music therapy for recent-onset tinnitus according to the "Heidelberg Model" introduced in this pilot study seems to provide an effective treatment option for patients with recent-onset tinnitus.

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Pharmacotherapy of acute and chronic hearing loss

Cited by 10 publications

References 30 publications

Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy

Cortical reorganization in recent-onset tinnitus patients by the Heidelberg Model of Music Therapy

Heidelberg Neuro-Music Therapy Restores Attention-Related Activity in the Angular Gyrus in Chronic Tinnitus Patients

Neuro-Music Therapy for Recent-Onset Tinnitus

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