Pharmacotherapy for allergic rhinitis

Platt, Michael P.

doi:10.1002/alr.21381

Cited by 29 publications

(48 citation statements)

References 41 publications

(58 reference statements)

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“…Drugs for AR are reported to decrease salivary flow rate and play a role in the development of caries. 14,17 Second-generation antihistamines have less anticholinergic effects than first-generation antihistamines. The associated decrease in salivary flow is also less.…”

Section: Discussionmentioning

confidence: 99%

Allergic rhinitis, rather than asthma, is a risk factor for dental caries

Chuang

Sun

2017

Clinical Otolaryngology

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Section: Discussionmentioning

confidence: 99%

Allergic rhinitis, rather than asthma, is a risk factor for dental caries

Chuang

Sun

2017

Clinical Otolaryngology

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“…Re‐exposure to specific antigens activates the sensitized mast cells; the mast cells then release chemical mediators, such as histamine, leukotrienes, serotonin, among others, to evoke AR clinical attacks . Although administration of histamine receptor antagonists or stabilizing mast cell membrane can satisfactorily inhibit AR symptoms, the therapeutic effects only last for a short time because this kind of treatment is only symptom control, it does not regulate the skewed Th2 polarization …”

Section: Introductionmentioning

confidence: 99%

Interleukin-5 induces apoptotic defects in CD4+ T cells of patients with allergic rhinitis

Luo

Wang

et al. 2019

Journal of Leukocyte Biology

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T helper (Th)2 polarization plays an important role in the pathogenesis of allergic diseases; the underlying mechanism remains to be further investigated. B cell lymphoma protein‐2 like protein‐12 (Bcl2L12) has the anti‐apoptotic function. This study aims to elucidate the contribution of Bcl2L12 to Th2 polarization in patients with allergic rhinitis (AR). In this study, human CD4+ T cells were isolated from blood samples collected from AR patients and healthy control (HC) subjects. The immune response profiles of CD4+ T cells were analyzed by immunologic approaches. The results showed that AR CD4+ T cells (CD4+ T cells collected from AR patients) showed defects of apoptosis. The expression of FasL in AR CD4+ T cells was lower than that of HC CD4+ T cells. Serum IL‐5 levels were negatively correlated with the expression of FasL in AR CD4+ T cells. Exposure of CD4+ T cells to IL‐5 in the culture suppressed the expression of FasL and increased the expression of Bcl2L12. IL‐5 increased the levels of Bcl2L12 in CD4+ T cells, the latter bound to the FasL promoter to prevent FasL gene transcription. Inhibition of Bcl2L12 restored the apoptosis machinery in AR CD4+ T cells. In conclusion, overexpression of Bcl2L12 in CD4+ T cells compromises the apoptosis machinery; the latter can be restored by inhibition of Bcl2L12. BcL2L12 in CD4+ T cells may be a novel target for the treatment of AR and other allergic disorders.

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“…Further support for a neurologic mechanism is that these conditions seem to be responsive to treatment with capsaicin or anticholinergic drugs. 3,67,68 Further endotypes of IR could be defined by the trigger type; for example, irritantsensitive IR. 8 An irritant-induced umbrella phenotype that includes not only IR but other entities such as occupational rhinitis subphenotypes has been proposed (see Fig.…”

Section: Idiopathic Rhinitismentioning

confidence: 99%

Rhinitis Subtypes, Endotypes, and Definitions

Papadopoulos

Guibas

2016

Immunology and Allergy Clinics of North America

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Rhinitis is often seen as posing a small burden. However, rhinitis is a complex disease that is underpinned by a plethora of different mechanisms and causes. Rhinitis is frequently associated with other comorbid conditions but, by itself, is a source of considerable morbidity for patients and creates a significant financial burden on health systems worldwide. This article approaches this condition from both a phenotypic and mechanistic standpoint, focusing on the complexity of characterizing these subtypes. Developing a clearer demarcation of the currently obscure rhinitis phenotypes and endotypes will substantially improve their future prevention and treatment.

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Pharmacotherapy for allergic rhinitis

Abstract: Pharmacotherapies for allergic rhinitis offer numerous options that are safe, effective, and readily available to target specific nasal symptoms. Symptom-based selection of allergy medications can result in optimal treatment for patients with allergic rhinitis.

Cited by 29 publications

References 41 publications

Allergic rhinitis, rather than asthma, is a risk factor for dental caries

Allergic rhinitis, rather than asthma, is a risk factor for dental caries

Interleukin-5 induces apoptotic defects in CD4+ T cells of patients with allergic rhinitis

Rhinitis Subtypes, Endotypes, and Definitions

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