Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders

Ipser, Jonathan; Carey, Paul D.; Dhansay, Yumna; Fakier, Nuraan; Seedat, Soraya; Stein, Dan J.

doi:10.1002/14651858.cd005473.pub2

Cited by 76 publications

(73 citation statements)

References 99 publications

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“…We selected the 2005 guidelines commissioned by the National Institute for Clinical Excellence for the management of post-traumatic stress disorder in primary care, 422 but none of the selected intervention studies in those guidelines provided evidence for immigrants or refugees. We also selected four Cochrane reviews on treatment of post-traumatic stress disorder, [423][424][425][426] the practice guidelines from the International Society for Traumatic Stress Studies 427 and a systematic review on treatment of this condition in refugees and asylum seekers. 428 …”

Section: Resultsmentioning

confidence: 99%

Evidence-based clinical guidelines for immigrants and refugees

Pottie¹,

Greenaway²,

Feightner³

et al. 2010

Canadian Medical Association Journal

381

333

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Section: Resultsmentioning

confidence: 99%

Evidence-based clinical guidelines for immigrants and refugees

Pottie¹,

Greenaway²,

Feightner³

et al. 2010

Canadian Medical Association Journal

381

333

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“…Unfortunately, the medications that are currently used have undesirable side effects and a significant number of patients are resistant to these first-line treatments [21,22]. Consequently, the demand for alternative pharmacological agents is growing.…”

Section: Discussionmentioning

confidence: 99%

The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice

et al. 2009

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The consumption of flavonoid-rich foods, in particular fruits and vegetables, has been epidemiologically associated with a reduced risk of heart disease, neurodegenerative disease, cancer and other chronic diseases. Flavonoid glycosides, the main class of flavonoids, have been shown to exert CNS-mediated activities, particularly as sedative-hypnotics, analgesics or both, nevertheless no studies have evaluated these agents in anxiety. This study assessed the potential anxiolytic effect of three flavonoid glycosides, myrcitrin, naringin and gossypin, in the elevated plus maze test (EPM). Myricitrin (1 mg/kg) was effective on the EPM showing a clear anxiolytic effect with no signs of sedation. However, higher doses showed possible sedative and myorelaxation effects. Gossypin and naringin both shared a similar profile, with low doses (1 mg/kg) inducing a robust anxiolytic effect which diminished with increasing doses of the flavonoids. Higher doses of these two flavonoids showed a dramatic increase in the open arm exploration accompanied by a decrease in locomotor activity. Hence, naringin (30 mg/kg) and gossypin (30 mg/kg) induce both anxiolytic and sedative effects. These results suggest that flavonoid glycosides have the potential to exert a range of CNS-mediated biological activities.

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“…Systematic reviews and meta-analyses, including Cochrane reviews, of the pharmacotherapy of SAD and treatment-resistant SAD have been undertaken [6][7][8]. On the basis of the primary literature, such reviews and meta-analyses, and ongoing clinical experience, guidelines for the pharmacotherapy of SAD have been published [9•, 10, 11].…”

Section: Introductionmentioning

confidence: 99%

A 2010 Evidence-Based Algorithm for the Pharmacotherapy of Social Anxiety Disorder

Stein

Baldwin

Bandelow

et al. 2010

Curr Psychiatry Rep

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A growing evidence base on the management of social anxiety disorder has yielded many meta-analyses and guidelines on the pharmacotherapy of this clinically important condition. We aimed to update a pharmacotherapy algorithm for the treatment of social anxiety disorder that was developed to be concise and user friendly and that was addressed to the primary care practitioner in particular. The updated algorithm attempts to summarize succinctly the recent literature in this area, as well as to include the views of an international panel of experts with diverse experience. The algorithm comprises eight sequential steps, beginning with those focused on diagnosis and initiating treatment and ending with the management of the treatment-refractory patient.

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Pharmacotherapy augmentation strategies in treatment-resistant anxiety disorders

Cited by 76 publications

References 99 publications

Evidence-based clinical guidelines for immigrants and refugees

Evidence-based clinical guidelines for immigrants and refugees

The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice

A 2010 Evidence-Based Algorithm for the Pharmacotherapy of Social Anxiety Disorder

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