Pharmacotherapeutic values of berberine: A Chinese herbal medicine for the human cancer management

Devarajan, Nalini; Nathan, Jhansi; Mathangi, R; Mahendra, Jaideep; Kumar, Ganesan Senthil

doi:10.1002/jbt.23278

Cited by 11 publications

(5 citation statements)

References 125 publications

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“…A growing number of studies in recent years indicate that BBR has inhibitory effects on a various cancer types, including glioblastoma, colorectal, lung, prostate, and ovarian cancer (Devarajan et al, 2023; Eom et al, 2008; Jin et al, 2018; Liu et al, 2015; Meeran et al, 2008; Peng et al, 2006). Also, BBR has recently been linked to an anti‐angiogenic mechanism that inhibits angiogenesis in cell‐based assays and a mouse xenograft model of human glioblastoma (Eom et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Nathan,

Shameera,

Devarajan

et al. 2023

J of Applied Toxicology

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Angiogenesis and hemodynamic instability created by the irregular blood vessels causes hypoperfusion and angiogenesis‐mediated diseases. Therefore, therapies focusing on controlling angiogenesis will be a valuable approach to treat a broad spectrum of diseases. In this study, we explored the anti‐angiogenic potential of berberine (BBR) and also analyzed blood flow hemodynamics using zebrafish embryos. Zebrafish embryos treated with BBR (0.01–0.75 mM) at various doses at 1 hour post‐fertilization (hpf) developed a variety of phenotypic variations including aberrant blood vessels, tail bending, edema, and hemorrhage. Survival rates were much lower at higher dosages, and hatching rates were almost 99%, whereas control group appeared normal. Heart rate is an essential measure that has a strong association with hemodynamics. We used ImageJ software to study the heart rate of embryos treated with BBR, preceded by video processing. The resultant graph shows a significant decrease in heart rate of embryos treated with BBR in dose‐dependent manner. Also, RBC staining using o‐Dianisidine confirms the anti‐angiogenic potential of BBR by indicating the decrease in the intersegmental vessels at 0.5 and 0.75 mM treated embryos. Further, the gene expression study determined that the transcripts (vegf, vegfr2, nrp1a, hif‐1α, nos2a, nos2b, cox‐2a, and cox‐2b) measured were found to be downregulated by BBR at 0.5 mM concentration, from which we conclude that enos/vegf signaling could play an important role in modulating angiogenesis. Our data imply that BBR may be an effective compound for suppressing angiogenesis in vivo, which might be helpful in the treatment of vascular disorders like cancer and diabetic retinopathy in future.

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Section: Discussionmentioning

confidence: 99%

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Nathan,

Shameera,

Devarajan

et al. 2023

J of Applied Toxicology

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“…[19] The alkaloid induces tumor apoptosis, suppresses metastasis, and even makes tumor cells more sensitive to drugs and treatments used. [20]…”

Section: Shows Good Results In Cancer Therapymentioning

confidence: 99%

Сок Барбариса: 10 Научно Доказанных Полезных Свойств Для Улучшения Здоровья

Ткачева Наталья,

Елисеева Татьяна

2023

ЖЗПД

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Мало кто знает, что ягоды, вкус которых большинству из нас знаком с детства благодаря знаменитым леденцам барбарискам, также широко используются в современной кулинарии, косметологии и даже народной медицине. Из плодов барбариса, или, как его еще называют конфетного дерева, варят разнообразные джемы, компоты и мармелады. Продолговатые кисленькие ягоды красно-винного цвета очень популярны в кавказской и азиатской кухнях — их используют в качестве оригинальной приправы при приготовлении плова и ризотто. А еще из мякоти барбариса отжимают полезный фреш. Напиток не только приятен на вкус, но и помогает справиться со многими проблемами организма. В широкой продаже натуральный барбарисовый сок практически не встречается, но его можно приготовить самостоятельно. HTML версия статьи

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“…Notably, previous research has unraveled the critical role of TCM in the treatment of diseases, especially cancers. [ 18 , 19 ] Meanwhile, TCM is selected as an auxiliary treatment for cancer surgery in some cases. [ 20 , 21 ] Therefore, it is imperative to explore the potential role of TCM in cancer treatment and expand its application scope.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Piwei Peiyuan Prescription in the treatment of chronic atrophic gastritis: A multicenter, double-blind, double-simulated, randomized, controlled clinical trial

Zhang,

Yang,

Song

et al. 2024

Medicine

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The incidence of chronic atrophic gastritis (CAG) is on the rise due to the growing pressure in modern social life, increasing bad living habits and emotional disorders (such as anxiety and depression), and the aging of the population. Of note, digestive system diseases are the dominant diseases in the field of traditional Chinese medicine (TCM). Therefore, this study evaluated the efficacy and safety of Piwei Peiyuan Prescription, a TCM prescription, in the treatment of CAG through a multicenter, double-blind, randomized, controlled design. This research was organized by the Second Affiliated Hospital of Anhui University of TCM and simultaneously performed in 6 centers. A total of 120 CAG patients were included and randomized into 2 groups: group A (treatment with Piwei Peiyuan granules plus Weifuchun Simulant) and Group B (treatment with Weifuchun Tablets plus Piwei Peiyuan Simulant). These 2 groups were compared in terms of gastroscopy scores, TCM syndrome scores, and serological indicators at baseline and within 12 weeks after treatment. According to endoscopic biopsy for pathological observation, atrophy (2.56 ± 1.08 vs 3.00 ± 1.00, P = .028) and intestinal epithelial hyperplasia (1.00 ± 1.43 vs 1.69 ± 1.80, P = .043) scores were lower in group A than in group B. For the more, group A had higher effective rates for inflammation, atrophy, and intestinal metaplasia (IM) in various regions of the stomach, especially for atrophy/IM of the gastric angle (64%, P = .034) and atrophy/IM of the lesser curvature of gastric antrum (63%, P = .042) than group B. According to TCM syndrome scores, Piwei Peiyuan Prescription improved the scores of gastric distension (2.30 ± 1.13 vs 2.80 ± 0.99, P = .022), preference for warmth and pressure (1.44 ± 1.06 vs 1.36 ± 1.10, P = .041), and poor appetite and indigestion (0.78 ± 0.66 vs 1.32 ± 0.72, P = .018). GAS, MTL, and PGE2 expression was significantly elevated after treatment with Piwei Peiyuan Prescription (P < .001). Piwei Peiyuan Prescription is effective for CAG treatment with high safety.

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Pharmacotherapeutic values of berberine: A Chinese herbal medicine for the human cancer management

Cited by 11 publications

References 125 publications

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model

Сок Барбариса: 10 Научно Доказанных Полезных Свойств Для Улучшения Здоровья

Efficacy and safety of Piwei Peiyuan Prescription in the treatment of chronic atrophic gastritis: A multicenter, double-blind, double-simulated, randomized, controlled clinical trial

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