Pharmacotherapeutic potential of phytochemicals: Implications in cancer chemoprevention and future perspectives

Kaur, Varinder; Kumar, Manish; Kumar, Ajay; Kaur, Kamaldeep; Dhillon, Varinderpal S.; Kaur, Satwinderjeet

doi:10.1016/j.biopha.2017.10.124

Cited by 80 publications

(33 citation statements)

References 231 publications

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“…Dietary intake of fruits and vegetables that are rich in bioactive carotenoids and other antioxidant phytochemicals (e.g., polyphenols, terpenoids, and isothiocyanantes) is associated with lower risk of chronic conditions and diseases, such as age-related macular degeneration, cardiovascular diseases (CVD), diabetes, neurodegenerative disorders, and several types of cancer [1][2][3][4][5][6][7]. Among females, cervical cancer is the fourth most commonly diagnosed malignancy in women worldwide, after malignancy of breast, colorectal, and lungs [8].…”

Section: Introductionmentioning

confidence: 99%

Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis

et al. 2019

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The present study was aimed to assess cellular and molecular events involved in the chemopreventive activities of β-cryptoxanthin derived from mandarin oranges (Citrus unshiu Marc.) on human cervical carcinoma (HeLa) cells. In vitro experiments established that β-cryptoxanthin significantly inhibited the proliferation of HeLa cells with the IC50 value of 4.5 and 3.7 µM after 24 and 48 h of treatments, respectively. β-cryptoxanthin-treated HeLa cells exhibited enhanced levels of oxidative stress correlated with significant downregulation of anti-apoptotic Bcl-2, and upregulation of pro-apoptotic Bax mRNA expression. Moreover, β-cryptoxanthin triggered nuclear condensation and disruption of the integrity of the mitochondrial membrane, upregulated caspase-3, -7, and -9 mRNA, and enhanced activation of caspase-3 proteins, resulting in nuclei DNA damage and apoptosis of HeLa cells. Remarkably, TUNEL assay carried out to detect nuclei DNA damage showed 52% TUNEL-positive cells after treatment with a physiological concentration of β-cryptoxanthin (1.0 μM), which validates its potential as an anticancer drug of natural origin.

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Section: Introductionmentioning

confidence: 99%

Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis

et al. 2019

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“…The chemopreventive properties of phytochemicals have been attracting more attention over the past decade [8,9], which inspired us to study the chemopreventive potential of various phytochemicals. In this study, we showed that tussilagone, a major component of T. farfara L, could suppress colonic tumorigenesis induced by AOM/DSS.…”

Section: Discussionmentioning

confidence: 99%

“…Phytochemicals have been drawing increasing attention for cancer prevention because of their chemical diversity, structural complexity, intrinsic biological activity, simple obtainability, affordability, lack of toxic effects and ability to control a variety of signal transduction pathways and cell processes [8,9]. In fact, we reported several laboratory-based studies of the antitumor effects of bioactive phytochemicals [10][11][12][13] Tussilagone (7R,14R)-14-Acetoxy-7-((2 E)-3 -methylpent-2 -enoyloxy)-oplopanone ( Figure 1a), is the major component of Tussilago farfara L. (Compositae).…”

Section: Of 13mentioning

confidence: 99%

Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer

Nam

Kim

2020

Biomedicines

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Background: Tussilagone, a major component of Tussilago farfara L., has anti-angiogenic and anti-inflammatory effects. However, the therapeutic and preventive activity of tussilagone in colitis-associated colon carcinogenesis is unknown. Methods: We intended to investigate the therapeutic effects and the potential mechanism of action underlying the pharmacological activity of tussilagone on colitis-associated colon cancer induced in mice using azoxymethane (AOM)/dextran sulfate sodium (DSS). We injected BALB/c mice with AOM and administered 2% DSS in drinking water. The mice were given tussilagone (2.5 and 5 mg/kg body weight) and colon tissues was collected at 72 days. We used Western blotting, immunohistochemistry and real-time RT-PCR analyses to examine the tumorigenesis and inflammatory status of the colon. Results: Tussilagone administration significantly reduced the formation of colonic tumors. In addition, tussilagone treatment markedly reduced the inflammatory mediators and increased heme oxygease-1 in protein and mRNA levels in colon tissues. Meanwhile, nuclear NF-κB-positive cells were elevated and nuclear Nrf2-positive cells were demised by tussilagone treatment in colon tissues. Tussilagone also reduced cell proliferation, induced apoptosis and decreased the β-catenin expression. Conclusions: Tussilagone administration decreases the inflammation and proliferation induced by AOM/DSS and induced apoptosis in colon tissue. Overall, this study indicates the potential value of tussilagone in suppressing colon tumorigenesis.

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“…В некоторых эпидемиологических исследованиях приведены убедительные доказательства наличия тесной обратной связи увеличения потребления овощей, фруктов, цельных злаков, бобовых, специй с риском развития онкологических заболеваний [4,5]. Результаты экспериментальных исследований подтверждают, что многие биологически активные компоненты растительных продуктов (БАКРП): флавоноиды, фенольные кислоты, индолы, ретиноиды, витамины и др.могут модулировать метаболизм ксенобиотиков, изменять активность ферментов, репарирующих ДНК, ингибировать клеточную пролиферацию, замедляя рост опухолей [5][6][7]. Можно ожидать, что эффекты БАКРП с присущим им антиоксидантным потенциалом затронут NO-сигнальные пути через прямое взаимодействие с NO и его активными формами, нивелируя их действие или через блокирование факторов, влияющих на образование NO: ядерного фактора κB (NF-κB), активатора белка 1 (AP-1) или митогенактивирующих протеинкиназ (MAPK) и др.…”

Section: обзорные статьиunclassified

Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis

Дерягина¹,

Реутов²

2019

Usp. mol. onkol

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В обзоре анализируются данные литературы и результаты собственных исследований о роли активных форм азота (NO, NO 2 , N 2 O 3) в инициации и прогрессии опухолей. Анализируется возможность модуляции активности индуцибельной NO-синтазы биологически активными компонентами растительных продуктов и их влияние на канцерогенез. Обсуждаются возможные механизмы неоднозначного действия NO и продуктов его метаболизма в канцерогенезе. Обобщение и анализ этих данных позволили сформулировать некоторые принципы применения веществ, модулирующих активность индуцибельной NO-синтазы и влияющих на образование NO и продуктов его метаболизма при ингибировании канцерогенеза.

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Pharmacotherapeutic potential of phytochemicals: Implications in cancer chemoprevention and future perspectives

Cited by 80 publications

References 231 publications

Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis

Chemopreventive Effect of β-Cryptoxanthin on Human Cervical Carcinoma (HeLa) Cells Is Modulated through Oxidative Stress-Induced Apoptosis

Tussilagone Reduces Tumorigenesis by Diminishing Inflammation in Experimental Colitis-Associated Colon Cancer

Modulation of the formation of active forms of nitrogen by ingredients of plant products in the inhibition of carcinogenesis

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