Pharmacotherapeutic agents used in temporomandibular disorders

Küçük, Burcu Bal; Kaya, Seda; Motro, P Karagoz; Oral, Koray

doi:10.1111/odi.12255

Cited by 8 publications

(8 citation statements)

References 34 publications

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“…Pharmacological treatment is frequently recommended for orofacial pain 42 ; however, we found only 6 (18%) RTCs using pharmacological treatments for TMD. Most of the existing literature evaluating pharmacologic treatments are observational clinical studies instead of RCTs 40,59 . The selected studies evaluated the effects of benzodiazepine (16%) 59 , anti-inflammatory (33%) 10,53 , myorelaxant drugs (16%) 44 , melatonin (16%) 45 , and TCA and gabapentin (16%) 60 .…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacological treatment is a common approach for orofacial pain as a monotherapy or associated with other therapies and surgical interventions. Used alone, it is considered a palliative therapy 39,40 . The most commonly used drugs to decrease pain and inflammatory process in joints and/or muscles are myorelaxants, non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, tricyclic antidepressants (TCAs), benzodiazepines, and corticosteroids 9,39,41 .…”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

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Non-invasive therapies for management of temporomandibular disorders: a systematic review

Brochado

Jesus

Martins

et al. 2019

CBR

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Introduction: As a multifactorial disease, temporomandibular disorders (TMD) require a complex therapeutic approach, being noninvasive therapies the first option for most patients. The aim of this study was to perform a systematic review to analyze the most common non-invasive therapies used for TMD management. Methods: The review was done by searching electronic databases to identify controlled clinical trials related to pharmacologic and non-invasive treatments. Of all potential articles found, 35 were included in this review. Results: Low-level laser therapy (LLLT), occlusal splints (OS) and oral exercises/ behavior education (OE/BE) were the most common therapies used. LLLT showed significant results in pain and movement improvement in most studies. OS was usually combined to other therapies and resulted in improvement of pain. OE/BE showed significant results when combined with ultrasound, LLLT, and manual therapy. Conclusions: Non-invasive treatments can provide pain relief and should be prescribed before surgical procedures. LLLT was the therapy with the higher number of studies showing positive results. Based in heterogeneity of treatment protocols, diagnostic and outcomes criteria used, new well-designed randomized controlled trials (RCT) are necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Pharmacological Treatmentsmentioning

confidence: 99%

Non-invasive therapies for management of temporomandibular disorders: a systematic review

Brochado

Jesus

Martins

et al. 2019

CBR

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“…13 Contudo, pode ser considerada uma terapia complementar. 26 Ainda sobre tratamentos não invasivos, as sessões múltiplas de manipulação facial fornecem uma pressão digital profunda exercida sobre centros específicos de nódulos musculares selecionados de acordo com exame clínico preciso. Os pacientes são submetidos a três sessões de manipulação facial de 50 minutos por semana.…”

Section: Discussionunclassified

Avaliação dos diferentes protocolos de tratamento da Disfunção Temporomandibular miogênica: Revisão de Literatura

Rodrigues¹,

Cabral²,

Lima³

et al. 2018

Rev. Fac. Odontol. Lins

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Introdução: A síndrome dolorosa miofascial (SDMf) é definida como disfunção neuromuscular caracterizada pela presença de contratura muscular e sintomotologia. Devido ao carácter multifatorial, vários tratamentos, isolados ou concomitantes, são indicados para essa disfunção. Apesar de diversos estudos disponíveis na literatura sobre essas modalidades de terapia, esses são pouco conclusivos. Objetivo: Revisar a literatura apresentando os diferentes tipos de tratamentos empregados para SDMf. Materiais e Métodos: A estratégia de busca foi realizada na base de dados do Pubmed, Scielo e Cochrane por meio dos seguintes descritores: Temporomandibular Joint Disorders, Myofascial Pain Syndromes, treatment, Randomized Controlled Trial. A avaliação dos estudos foi realizada em duas etapas por revisores independentes. Na primeira etapa, os títulos e resumos foram investigados e aqueles que apresentassem os critérios de elegibilidade eram selecionados. Na segunda etapa, os artigos foram lidos na íntegra e posteriormente incluídos conforme o consenso dos dois revisores baseando-se nos critérios de inclusão e exclusão. Resultados: 100 citações foram identificadas e 43 lidas na íntegra. 8 artigos reuniram os critérios de elegibilidade. Diversos tratamentos foram abordados como orientações ao paciente, tratamento fisioterapêutico, odontológico e terapia medicamentosa. Conclusão: As terapias como as orientações, treinamento com relaxamento muscular, exercícios da mandíbula, manipulação facial, terapia com placa oclusal, toxina botulínica, acupuntura são eficazes no controle da dor miofascial.

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“…Narcotics (opioids), and 2. Non-narcotics including salicylates, para-amino-phenol derivatives (acetaminophen) and non-steroidal antiinflammatory drugs (NSAIDs) (5).…”

mentioning

confidence: 99%

Contemporary Topical Therapeutics for Temporomandibular Joint Pain; A Review of the Literature

Mortazavi

Nodehghan²,

Valizadeh³

et al. 2018

Avicenna J Dent Res

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Context The issue of pharmacotherapy safety in treating musculoskeletal pain, has brought attention to topical application, a safe and still effective route of drug delivery. Evidence Acquisition This review focuses on the topical agents used in temporomandibular disorders (TMDs). An advanced search of publications starting from 1980 through 2016 was made in ScienceDirect, PubMed, Medline, and Google Scholar databases using different combinations of keywords ("topical medication" OR "topical therapeutic" OR "topical pharmacotherapeutic agent" OR "topical analgesic") AND ("temporomandibular joint" OR "temporomandibular disorder" OR "temporomandibular joint dysfunction" OR "temporomandibular joint pain"). The relevance of searched articles to topical pharmacotherapy of temporomandibular joint disorders was considered and the following eligibility criteria were implied: 1) original articles; 2) English-language articles; and 3) full-text articles. TMDs are recently classified as muscle disorders, disc displacements, arthralgia, osteoarthritis and osteoarthrosis (1). TMDs are the most common musculoskeletal condition after chronic low back pain (2). The TMJ pain may be resulted from sensitization of trigeminal sensory neurons innervating the TMJ region (3). A patient with TMD may also have a pain complaint in the neck, shoulder or upper neck region (4). As for other musculoskeletal disorders, pharmacotherapy may be

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Pharmacotherapeutic agents used in temporomandibular disorders

Cited by 8 publications

References 34 publications

Non-invasive therapies for management of temporomandibular disorders: a systematic review

Non-invasive therapies for management of temporomandibular disorders: a systematic review

Avaliação dos diferentes protocolos de tratamento da Disfunção Temporomandibular miogênica: Revisão de Literatura

Contemporary Topical Therapeutics for Temporomandibular Joint Pain; A Review of the Literature

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