Pharmacomodulation d'arylcétones thiophéniques anti-agrégantes plaquettaires

Analysis of substituent effects on the carbon-13 and oxygen-17 NMR chemical shifts of some phenylthiophen-2′-ylmethanones by linear free energy relationships

“…Compounds 1 were prepared according to the general method (Friedel-Crafts acylation) reported previously 30 and the melting-points agree with those given in the literature.…”

Transition‐Metal Catalyzed Coupling Reactions for the Synthesis of (Het)aryl Ketones: An Approach from their Synthesis to Biological Perspectives

“…Different thiophene based ketone molecules have been reported as potential inhibitors of cyclooxygenase enzymes (1), [14] allosteric modulators of the A1 adenosine receptors (13) [15] and anti-aggregating agents (15). [16] Venkataramireddy and colleagues reported the anticancer activity of (3) against Human colon cancer cell lines (HCT-15) using MTT assay. The compound 3 showed IC50 value of 21 μg/mL against studied cancer cell line.…”

“…Lanperisone ( 7 ) is also another ketone bearing drug which is used as muscle relaxant. Different thiophene based ketone molecules have been reported as potential inhibitors of cyclooxygenase enzymes ( 1 ), [14] allosteric modulators of the A1 adenosine receptors ( 13 ) [15] and anti‐aggregating agents ( 15 ) [16] . Venkataramireddy and colleagues reported the anticancer activity of ( 3 ) against Human colon cancer cell lines (HCT‐15) using MTT assay.…”

Sentitized near-infrared emission in novel neodymium complexes bearing oligothiophene derivatives as antennae

“…The ligands were obtained by the Friedel-Craft acylation with 2,3-dimethoxybenzoic acid of 2-bromothiophene, 2,2 -bithiophene or 2,2 :5 ,2 -terthiophene, respectively, following a the synthetic procedures reported in literature for thiophene acylation [5].…”