Pharmacology of Tranquillizing Drugs

Vogt, Marthe

doi:10.1136/bmj.2.5102.965

Cited by 12 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to their tendency to migrate, they formed colonies of loose texture in single-cell platings. Cells of the F8 line were 10-1 5 times more resistant to poliovirus than the cells of the Stl line (VOGT 1958). A karyotype with 70 (nine large) chromosomes remained the most frequent karyotype over a culture period of six to 13 months (Figure 2 ) .…”

Section: Resultsmentioning

confidence: 96%

“…Karyotype distributions of the parental lines: The origin of the two parental lines, Sty, and F8, has been described previously (VOGT 1958). At the time of isolation the cells of clone S t l were polygonal in shape and formed tightly packed colonies in single-cell platings.…”

Section: Resultsmentioning

confidence: 99%

“…Cell line: The two clones, Stl and F8, of strain HeLa used throughout this work were isolated from the clonal line S3 , kindly made available to us by DR. PUCK. The method of isolation and the properties of the two clones have been described previously (VOGT 1958).…”

Section: Materials a N D Methodsmentioning

confidence: 99%

See 2 more Smart Citations

A STUDY OF THE RELATIONSHIP BETWEEN KARYOTYPE AND PHENOTYPE IN CLONES LINES OF STRAIN HeLa

Vogt

1959

Genetics

View full text Add to dashboard Cite

KLEIN 1958) that cloned lines of tumor cells with distinct physiological or morphological properties frequently differ from one another in observable characteristics of their karyotypes. The obvious question arises: are the distinct physiological or morphological properties of the various cell lines caused by the differences in the karyotypes, or, are the latter only an additional expression of the great variability of tumor cells? Most workers in this field consider the present evidence insufficient to decide the question in either way. The purpose of this paper is to present further data bearing on the same question. As will be seen, the data favor strongly the assumption of a causal relationship between karyotype and phenotype in a tissue culture line of human neoplastic cells, the strain HeLa (GEY et al. 1952).Several factors may be held responsible for the difficulties encountered in a study of the relationship between karyotype and phenotype in tumor cell populations. One of the factors is the great frequency with which the karyotype changes in populations carrying aneuploid chromosome constitutions. In strain HeLa, for example, one out of a hundred mitoses on the average is abnormal (CHU and GILES 1958). Since most of these abnormal mitoses lead to an unequal distribution of the chromosomes to the daughter cells, new karyotypes are formed at a high frequency. Cloned cell populations contain therefore after a short period of growth a number of variant karyotypes. It was found possible to overcome this difficulty by studying the karyotypes of cloned populations within one to two months after the isolation from the single cell.Another difficulty in this study lies in the great variety of karyotypes that arise as a consequence of the large number of chromosomes and their more or less random reassortment during abnormal mitoses. Due to the great variety of possible chromosome combinations, many different karyotypes may be expected to lead to phenotypes indistinguishable in respect to the mutant character studied. This situation excludes, therefore, a priori, the possibility to find a one-to-one relationship between karyotype and phenotype, which would be the most direct evidence of a causal relationship between karyotype and phenotype.It is, however, possible to look for a part-a1 solution of the problem by studying the relationship between karyotype and phenotype in one direction only, that is,

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A STUDY OF THE RELATIONSHIP BETWEEN KARYOTYPE AND PHENOTYPE IN CLONES LINES OF STRAIN HeLa

Vogt

1959

Genetics

View full text Add to dashboard Cite

show abstract

“…It has been postulated that one way that the phenothiazines may act is through the reticular formation concerned with wakefulness (Vogt, 1958), and in a series of patients being treated by insulin there was a higher rate of epileptiform seizures when chlorproinazine was also given (Benaim, 1960).…”

Section: Mode Of Action and Effects Of Trifluoperazinementioning

confidence: 99%

The Indications for Combined Treatment with Trifluoperazine and Amylobarbitone

Whiteley

1961

Int J Clinical Practice

View full text Add to dashboard Cite

“…1972aFujita et al, 1966], Reserpine has a depletory effect on the neuronal con tent of serotonin [Shore et ah. 1957], epinephrine and norepinephrine [Vogt. 1958].…”

Section: Introductionmentioning

confidence: 99%

Effect of Reserpine on the Differentiation of the External Granular Layer of the Cerebellum in the Chick Embryo

Espinar

Quesada

Martı́nez-de-la-Torre

et al. 1987

Cells Tissues Organs

View full text Add to dashboard Cite

In this work we analyse the effect produced by reserpine on the development of thickness and cell number in the external granular layer in the cerebellum of chick embryo. A striking 48-hour histo genetic delay is observed in the treated embryos relative to controls, as show by greater thickness and cell density of this layer in the former, as well as by retarded appearance of a typical radial morphological organization of the external granular layer.

show abstract

Pharmacology of Tranquillizing Drugs

Cited by 12 publications

References 18 publications

A STUDY OF THE RELATIONSHIP BETWEEN KARYOTYPE AND PHENOTYPE IN CLONES LINES OF STRAIN HeLa

A STUDY OF THE RELATIONSHIP BETWEEN KARYOTYPE AND PHENOTYPE IN CLONES LINES OF STRAIN HeLa

The Indications for Combined Treatment with Trifluoperazine and Amylobarbitone

Effect of Reserpine on the Differentiation of the External Granular Layer of the Cerebellum in the Chick Embryo

Contact Info

Product

Resources

About