Pharmacology of palliative medicine

Mihelic, Ronald

doi:10.1053/j.soncn.2004.10.005

Cited by 7 publications

(7 citation statements)

References 31 publications

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“…A written record of medications and instructions of how medications need to be administered (strength, dosing frequency) will facilitate compliance and improve outcomes. 23 Example: If the patient keeps a record or log of the time and extra rescue doses given, this helps monitor symptoms severity and medication efficacy and aids dose titration. 2 15.…”

Section: Use Nonpharmacological Interventions Firstmentioning

confidence: 99%

Symptom Control in Advanced Cancer: Twenty Principles

Alvarez¹,

Walsh

2011

Am J Hosp Palliat Care

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In Palliative Medicine, symptom management is a clinical priority and one of the key skill sets of the palliative specialist. Symptom control principles have been derived from clinical practice in cancer pain management. They can also be applied to other cancer symptoms, and systematic application will help improve quality of life (QOL). They require a diagnosis of the underlying etiology, individualization of symptom therapy, a systematic approach to management, and therapeutic clarity and simplicity. There are 20 principles that have been identified as helpful to guide the clinical practice of symptom control in advanced cancer.

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Section: Use Nonpharmacological Interventions Firstmentioning

confidence: 99%

Symptom Control in Advanced Cancer: Twenty Principles

Alvarez¹,

Walsh

2011

Am J Hosp Palliat Care

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“…Small intestine resections involving the loss of more than 100 cm of ileum frequently lead to malabsorption, which could also decrease drug absorption. [14] Absorption might also be decreased by alterations in gut wall function, which is caused by body wasting or cachexia, or decreased splanchnic perfusion. [13,15]…”

Section: Article Highlightsmentioning

confidence: 99%

“…[27] Hypoalbuminemia is, therefore, often seen in various types of cancer, cachectic patients, and hospitalized or institutionalized elderly patients. [14,[28][29][30][31][32] Increased plasma levels of AAG have also been shown in various types of cancer, acute illness, or chronic disease. [33,34] As a result, highly AAG bound drugs will have decreased unbound concentrations while highly albumin bound drugs will have increased unbound concentration.…”

Section: Protein Bindingmentioning

confidence: 99%

Pharmacokinetic considerations and recommendations in palliative care, with focus on morphine, midazolam and haloperidol

Franken

Winter

Esch

et al. 2016

Expert Opinion on Drug Metabolism & Toxicology

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The pharmacokinetics of drugs in terminally ill patients can be complex and limited evidence exists on guided drug use in this population. To improve the quality of life of these patients, more knowledge and more pharmacokinetic/pharmacodynamics studies in terminally ill patients are needed to develop individualised dosing guidelines. Until then knowledge of pharmacokinetics and the physiological changes that occur in the final days of life can provide a base for dosing adjustments that will improve the quality of life of terminally ill patients. As the interaction of drugs with the physiology of dying is complex, pharmacological treatment is probably best assessed in a multi-disciplinary setting and the advice of a pharmacist, or clinical pharmacologist, is highly recommended.

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“…The cytotoxic drugs used in chemotherapy fail to distinguish malignant cells from normal cells, prevent cell division and destroy cells equally (Mihelic, 2005). The cytotoxic drugs used in chemotherapy fail to distinguish malignant cells from normal cells, prevent cell division and destroy cells equally (Mihelic, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Lung cancer patients experience significant symptom distress caused by the primary tumour and its treatment. The cytotoxic drugs used in chemotherapy fail to distinguish malignant cells from normal cells, prevent cell division and destroy cells equally (Mihelic, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effects of cognitive education on the perceived control and symptom distress of lung cancer patients receiving chemotherapy: A randomised controlled trial

et al. 2019

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Aim:A randomised controlled trial (RCT) was implemented to verify the feasibility and acceptability of cognitive education in the format of mind maps for increasing perceived control and decreasing the symptom distress of lung cancer patients who were receiving chemotherapy.Methods: A total of 136 lung cancer patients who were receiving chemotherapy were randomised using stratified blocks (1:1 ratio,The intervention group was given cognitive education in the format of mind maps.The control group was provided conventional education. The primary outcomes were perceived control, including cancer experience and cancer efficacy; the secondary outcomes included symptom distress (arising from fatigue, distress, sleep disturbance, poor appetite, drowsiness, shortness of breath, etc.). The Mann-Whitney U test, chi-squared test, two-sample t test and repeated measurement analysis of variance were used.Results: Ninety-four patients completed the final study. The results of the repeated measurement analysis of variance indicated that at the 8th or 12th week following cognitive education intervention in the format of mind maps, the cancer experience, cancer efficacy (except personal efficacy) and symptom distress (arising from fatigue, distress, sleep disturbance, and sadness and its total scores) of the patients in the intervention group were considerably improved compared with those of the control group (p < 0.05). The longer the intervention was, the higher the level of the patients' perceived control was and the lower the degree of patient symptom distress was (p < 0.05). Conclusions:Our findings suggest that cognitive education in the format of mind maps could improve perceived control and decrease the symptom distress of lung cancer patients who were receiving chemotherapy and that it was feasible and acceptable. Cognitive education in the format of mind maps was found to be an effective teaching tool for lung cancer patients who were receiving chemotherapy. K E Y W O R D Schemotherapy, cognitive education, lung cancer, perceived control, symptom distress

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Pharmacology of palliative medicine

Cited by 7 publications

References 31 publications

Symptom Control in Advanced Cancer: Twenty Principles

Symptom Control in Advanced Cancer: Twenty Principles

Pharmacokinetic considerations and recommendations in palliative care, with focus on morphine, midazolam and haloperidol

Effects of cognitive education on the perceived control and symptom distress of lung cancer patients receiving chemotherapy: A randomised controlled trial

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