Pharmacology of drugs acting on gastrointestinal motility

Daniel, E. E.; Collins, Stephen M.; Fox, J. E. T.; Huizinga, Jan D.

doi:10.1002/cphy.cp060119

Cited by 8 publications

(7 citation statements)

References 310 publications

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“…A recent small study using MRI in 13 CD patients showed a strong, negative correlation between contraction frequency per minute in normal bowel segments and fC (R = 0.805, p = 0.001) 21 . In addition, a number of pre-clinical investigations relate even low-grade inflammatory activity to gut neuroplasticity (structural, synaptic or intrinsic changes that alter neuronal function) 53,54 .…”

Section: Discussionmentioning

confidence: 99%

Aberrant Motility in Unaffected Small Bowel is Linked to Inflammatory Burden and Patient Symptoms in Crohnʼs Disease

Menys¹,

Makanyanga²,

Plumb³

et al. 2016

Inflammatory Bowel Diseases

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Objectives: Inflammation related enteric dysmotility has been postulated as a cause for abdominal symptoms in Crohn's disease (CD). We investigated the relationship between MRI-quantified small bowel (SB) motility, inflammatory activity and patient symptom burden.Methods: The Harvey Bradshaw Index (HBI) and fecal calprotectin were prospectively measured in 53 CD patients (median age 35, range 18-78) the day before MRI enterography which included a dynamic (cine), breath-hold motility sequence, repeated to encompass the whole SB volume. A validated registration based motility quantitation technique produced motility maps and regions of interest were drawn to include all morphologically normal SB (i.e. excluding diseased bowel). Global SB motility was correlated with calprotectin, HBI and symptom components (wellbeing, pain, diarrhea). Adjustment for age, sex, smoking and surgical history was made using multivariate linear regression.Results: Median calprotectin was 336 (range 0-1280). Mean HBI, motility mean and motility variance were 3 (range 0-16), 0.33 (0.18 to 0.51) and 0.01 (0.0014 to 0.034) respectively. Motility variance was significantly negatively correlated with calprotectin (Rho = -0.33, P = 0.015), total HBI (rho = -0.45, P <0.001), wellbeing (rho= -0.4, p=0.003), pain (rho = -0.27, p =0.05) and diarrhea (rho= -0.4, p=0.0025). The associations remained highly significant after adjusting for covariates. There was no association between mean motility and calprotectin or HBI (p>0.05).Conclusions: Reduced motility variance in morphologically normal small bowel is associated with patient symptoms and fecal calprotectin levels, supporting the hypothesis that inflammation related enteric dysmotility may explain refractory abdominal symptoms in CD.

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Section: Discussionmentioning

confidence: 99%

Aberrant Motility in Unaffected Small Bowel is Linked to Inflammatory Burden and Patient Symptoms in Crohnʼs Disease

Menys¹,

Makanyanga²,

Plumb³

et al. 2016

Inflammatory Bowel Diseases

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“…Similar to the heart, in most muscles of the gastrointestinal tract fl-adrenergic stimulation increases cyclic AMP 368 ISO, VIP AND CGRP ON GASTRIC SMOOTH MUSCLE production. But in contrast, ,-adrenergic stimulation is coupled to inhibition of electrical and contractile activity in gastrointestinal muscles (Stiles et al 1984;Bulbring & Tomita, 1987;Daniel et al 1989). This suggests that channels in gastrointestinal muscles may be regulated in a different manner than cardiac channels by PKA-dependent phosphorylation.…”

Section: Discussionmentioning

confidence: 99%

“…The magnitude of the Ca2+ transients initiated by slow waves appears to be attenuated by stimulation of ,82-receptors. Since these receptors have been shown to be coupled to enhanced adenylate cyclase activity (for reviews, see Stiles, Caron & Lefkowitz, 1984;Bulbring & Tomita, 1987;Daniel, Collins, Fox & Huizinga, 1989), additional experiments were performed to test other agents known to stimulate adenylate cyclase.…”

Section: Effect Of Vip and Cgrp On Electrical Activity [Ca2+] T Andmentioning

confidence: 99%

Cyclic AMP‐mediated regulation of excitation‐contraction coupling in canine gastric smooth muscle.

Ozaki

Blondfield

Hori

et al. 1992

The Journal of Physiology

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“…The intra-arterial route of administration is very valuable for localizing sites of drug action [13]. For isoprénaline, we found a less potent inhibitory effect on both acid and pep sin secretion by the intra-arterial route.…”

Section: Discussionmentioning

confidence: 67%

“…Intra venous infusions of isoprénaline possessed an inhibitory effect on pepsin secretion throughout the infusion but inhibited the secretion only for the first 30 min using in tra-arterial infusions as the pepsin output then returned to control output although the infusion of isoprénaline continued. This could be due to tachyphylaxis of the primary inhibitory effect which is characteristic for drugs acting indirectly [13].…”

Section: Discussionmentioning

confidence: 99%

Intra-Arterial versus Intravenous Administration of Gastric Secretory Inhibitors in Conscious Dogs

Johansen

Bech²

1991

Eur Surg Res

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The purpose of the present study was to evaluate the effects of both intra-arterial and intravenous infusions of somatostatin, serotonin (5-hydroxytryptamine) and isoprenaline (β₁- + β₂-adrenoceptor agonist) on gastric acid and pepsin secretion in conscious dogs with a gastric fistula. The drugs mentioned have been examined earlier for effects on gastric secretion in vivo during intravenous infusions and these effects could be hampered by the possible indirect mechanism of action as well as the different kinetics of metabolism. A catheter (vascular access port) allowed repeatedly gastric intra-arterial infusions. Somatostatin and serotonin possessed inhibitory effects on gastric acid and pepsin secretion and were without significant differences between the analyzed ways of administration. Intra-arterial infusion, isoprenaline possessed less potent inhibitory effects on gastric secretion: the effects were significant for pepsin secretion but were nonsignificant for acid secretion. The results suggest the mechanism of action of isoprenaline, somatostatin and sertonin to diverge, and for somatostatin and serotonin it was independent of the route of administration.

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Pharmacology of drugs acting on gastrointestinal motility

Cited by 8 publications

References 310 publications

Aberrant Motility in Unaffected Small Bowel is Linked to Inflammatory Burden and Patient Symptoms in Crohnʼs Disease

Aberrant Motility in Unaffected Small Bowel is Linked to Inflammatory Burden and Patient Symptoms in Crohnʼs Disease

Cyclic AMP‐mediated regulation of excitation‐contraction coupling in canine gastric smooth muscle.

Intra-Arterial versus Intravenous Administration of Gastric Secretory Inhibitors in Conscious Dogs

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