Pharmacology of biliary tract

Behar, José; Biancani, Piero

doi:10.1002/cphy.cp060129

Cited by 5 publications

(4 citation statements)

References 194 publications

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“…Their studies have shown that sphincter-duodenal intrinsic myoneural continuity is an important requirement for the enhanced sphincter of Oddi activity observed during duodenal phase II and III of the interdigestive cycle and in the postprandial state. Motilin and cholecystokinin are known to be released from the duodenum during duodenal phase II/III of the interdigestive cycle and in the postprandial state, respectively (Behar & Biancani, 1989). Tanaka et al (1992) have provided evidence that the action of motilin and cearulein, a cholecystokinin analogue, to increase sphincter of Oddi activity may occur via intrinsic neural pathways, thus providing a neuro-hormonal mechanism for the co-ordination of biliary and duodenal motility.…”

Section: Discussionmentioning

confidence: 99%

Intramural neural pathways between the duodenum and sphincter of Oddi in the Australian brush‐tailed possum in vivo.

Saccone

Harvey

Baker

et al. 1994

The Journal of Physiology

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1. Balloon distension of the duodenum 2 cm oral or anal to the sphincter of Oddi-duodenal junction elevated the amplitude of spontaneous sphincter of Oddi phasic contractions by 37-7 + 8-5 or 120-1 + 79-8%, respectively (mean + S.E.M., both n= 6, P< 0 05, Wilcoxon test). To further investigate this response, this study aimed to determine if: (i) electrical field stimulation (EFS) of the duodenum influences sphincter of Oddi activity; (ii) intramural nerves mediate the response; and (iii) nicotinic and/or muscarinic receptors are involved. 2. Electrical field stimulation (70 V, 0 5 ms; 5-60 Hz, 10-20 s) of the duodenal anterior serosal surface 2-4 cm oral or anal to the sphincter of Oddi-duodenal junction, produced excitatory responses in the sphincter of Oddi in anaesthetized Australian brush-tailed possums (n = 45). 3. These responses were frequency dependent, maximal at 30 Hz (n = 4) and abolished by tetrodotoxin (9 jug kg-' I.A.; n = 6), or by crushing the duodenum (n = 3). Hexamethonium bromide (30 mg kg-' i.v.) did not significantly alter the response to duodenal EFS either oral (n =6) or anal (n =8) to the sphincter of Oddi-duodenal junction. Atropine sulphate (30 jug kg-' i.v.) reduced the response to duodenal EFS oral and anal to the sphincter of Oddi-duodenal junction to 11P2 + 5-8 (n = 6) and 45 0 + 26-8% (n = 8), respectively (both P< 0 05).4. Bilateral cervical vagotomy and guanethidine infusion (10 mg kg-' over 15 min i.v.) did not significantly alter the responses to duodenal EFS (n = 7). 5. Excitatory intramural neural pathways between the sphincter of Oddi and the segment of duodenum 4 cm oral and anal to the sphincter of Oddi-duodenal junction have been demonstrated. These postganglionic pathways may involve muscarinic receptors.

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Section: Discussionmentioning

confidence: 99%

Intramural neural pathways between the duodenum and sphincter of Oddi in the Australian brush‐tailed possum in vivo.

Saccone

Harvey

Baker

et al. 1994

The Journal of Physiology

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“…A variety of drugs acting on the cholinergic and adrenergic systems affect this motor activity [54], Organic nitrate were shown to reduce the pressure of the sphincter of Oddi and to relax the gall bladder, but only recently evidence was obtained that endogenous NO is produced by the gallbladder tissues and that NO may serve as a mediator of NANC nerves in the control of the contractions of the gallbladder and the sphincter of Oddi [55,56], As shown by Mourelle et al [55], after the inhibition of NOS with L-NMMA or L-NNA, the baseline gallbladder pressure significantly increased and the CCK-induced responses were also enhanced. These effects were reversed when L-arginine but not D-arginine was added.…”

Section: Implication Of No In the Contractile Activity Of The Gallblamentioning

confidence: 99%

Role of Nitric Oxide in the Digestive System

Konturek¹,

Konturek²

1995

Digestion

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“…Theoretically, in patients after ES, bile may escape directly from the bile duct to duodenum continuously because the sphincter no longer behaves as a resistor controlling the bile flow 29,30 . In previous studies by ultrasound and QC, filling of gallbladder and delayed biliary emptying occurred commonly after complete ES 31,32 .…”

Section: Discussionmentioning

confidence: 99%