Pharmacology of Analgesics

Shimoji, Koki; Fujioka, Hitoshi

doi:10.1007/978-981-15-2933-7_5

Cited by 1 publication

(1 citation statement)

References 90 publications

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“…As it was recently revealed that using NSAIDs increases the risk of myocardial infarction ( 155 ). Among the medications examined were Celecoxib, ibuprofen, diclofenac, naproxen, and rofecoxib ( 156 ). According to a study, many NSAID users reported gastrointestinal side effects ranging from nausea, slight pain, and dyspeptic symptoms to serious problems like bleeding, peptic ulcer rupture, and intestinal blockage ( 157 ).…”

Section: Advantages Challenges and Future Perspective Of Nsaidsmentioning

confidence: 99%

Non-steroidal anti-inflammatory drugs and biomarkers: A new paradigm in colorectal cancer

Rashid

Khan²,

Elsori³

et al. 2023

Front. Med.

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Colorectal cancer is a sporadic, hereditary, or familial based disease in its origin, caused due to diverse set of mutations in large intestinal epithelial cells. Colorectal cancer (CRC) is a common and deadly disease that accounts for the 4th worldwide highly variable malignancy. For the early detection of CRC, the most common predictive biomarker found endogenously are KRAS and ctDNA/cfDNA along with SEPT9 methylated DNA. Early detection and screening for CRC are necessary and multiple methods can be employed to screen and perform early diagnosis of CRC. Colonoscopy, an invasive method is most prevalent for diagnosing CRC or confirming the positive result as compared to other screening methods whereas several non-invasive techniques such as molecular analysis of breath, urine, blood, and stool can also be performed for early detection. Interestingly, widely used medicines known as non-steroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation have reported chemopreventive impact on gastrointestinal malignancies, especially CRC in several epidemiological and preclinical types of research. NSAID acts by inhibiting two cyclooxygenase enzymes, thereby preventing the synthesis of prostaglandins (PGs) and causing NSAID-induced apoptosis and growth inhibition in CRC cells. This review paper majorly focuses on the diversity of natural and synthetic biomarkers and various techniques for the early detection of CRC. An approach toward current advancement in CRC detection techniques and the role of NSAIDs in CRC chemoprevention has been explored systematically. Several prominent governing mechanisms of the anti-cancer effects of NSAIDs and their synergistic effect with statins for an effective chemopreventive measure have also been discussed in this review paper.

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Section: Advantages Challenges and Future Perspective Of Nsaidsmentioning

confidence: 99%