Pharmacology for the Interventional Pain Physician

Anitescu, Magdalena; Benzon, Honorio T.; Variakojis, Renata

doi:10.1016/b978-0-323-08340-9.00044-x

Cited by 9 publications

(5 citation statements)

References 236 publications

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“…We also choose to incorporate the continuous-valued cortisol concentration as a feature. This is because unbound blood cortisol is active biologically and has a contribution towards energy production [59]. The final state estimates are generally consistent with the known physiology of cortisol (e.g.…”

Section: Challengessupporting

confidence: 68%

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A Bayesian Filtering Approach for Tracking Sympathetic Arousal and Cortisol-Related Energy From Marked Point Process and Continuous-Valued Observations

Wickramasuriya,

Khazaei,

Kiani

et al. 2023

IEEE Access

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Multiple state variables governed by internal processes within the human body remain unobserved. On a number of occasions, these states are linked to point process bioelectric and biochemical observations coupled together with continuous-valued variables. These observations provide a means to estimate the latent states of interest. We develop a state-space method to estimate unobserved sympathetic arousal and energy production states from skin conductance and cortisol data respectively, comprising of a marked point process and a continuous-valued observation. The method involves Bayesian filtering applied within an expectation-maximization (EM) framework for state estimation and model parameter recovery. Results are evaluated on both simulated and experimental data. On experimental skin conductance data, high arousal levels are generally detected during cognitive stress periods and lower values are detected during relaxation. Results are also in conformity with general physiology for cortisol data. On separate experimental data, skin conductance-based estimates are validated/cross-checked with functional Near Infrared Spectroscopy features. Estimation is also performed on heart rate and skin conductance data to illustrate the method's wider applicability. We also compare the method with earlier approaches. We show how it outperforms a previous method for cortisol-based energy estimation, and its superiority to earlier methods for estimating sympathetic arousal. The EM approach is thus able to estimate latent physiological states within the body from point process bioelectric and biochemical phenomena. The method could be applied in wearable monitoring and automated closed-loop therapy delivery for patients diagnosed with certain types of neuropsychiatric or hormone disorders.INDEX TERMS Biomedical signal processing, state-space methods, estimation, emotion recognition, Kalman filters I. INTRODUCTIONS EVERAL internal state variables maintained by physiological processes within the human body remain largely unobserved. Nevertheless, they are often tied to more easilymeasured changes in biolelectric and biochemical phenomena that can be used for their estimation. For instance, energy

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Section: Challengessupporting

confidence: 68%

“…1. Now biologically-active unbound cortisol in the bloodstream, which forms only a single continuousvalued variable, contributes to energy production [59]. Consequently, the purely MPP-based method in [58] too cannot viably be applied to cortisol.…”

Section: B Related Work and Limitations -State-space Methodsmentioning

confidence: 99%

A Bayesian Filtering Approach for Tracking Sympathetic Arousal and Cortisol-Related Energy From Marked Point Process and Continuous-Valued Observations

Wickramasuriya,

Khazaei,

Kiani

et al. 2023

IEEE Access

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“…Injection therapy for the treatment of joint pain has been performed since the 1930's. The introduction of cortisone revolutionized the treatment of several medical diseases and injections of glucocorticoids for the relief of vertebrogenic, arthritic and radiculopathic pain are widely accepted (Anitescu et al, 2013). Diarthrodial joints are well suited to intra-articular injection and the local delivery of therapeutics in this fashion brings several potential advantages to the treatment of a wide range of arthropathies (Evans et al, 2014).…”

Section: Injection Therapymentioning

confidence: 99%

Key concepts for intra-articular corticosteroid injections for pathology of the first metatarsophalangeal joint: a scoping review protocol

Reilly¹

2021

Preprint

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Background: The two most common diseases affecting the first metatarso-phalangeal joint (1st MTP jt) of the foot are hallux limitus/rigidus (osteoarthritis) and hallux valgus (bunion), but other pathologies also affect the region. There are a range of treatments for these conditions: one treatment option is intra articular injection therapy, and this is one of the most common therapeutic interventions in musculoskeletal healthcare. Therapeutic injections of corticosteroids provide a treatment option for patients with joint or peri-articular pain, those who are not surgical candidates, in those in whom conservative treatment has failed or for those awaiting surgery. They are accepted as an important treatment modality, but currently there are no evidenced-based guidelines about administration technique or regimen of the 1st MTP jt. This is a scoping review protocol for the study to identify key concepts in intra-articular corticosteroid injections for pathology of the first metatarsophalangeal joint.Methods and analysis: Scoping reviews are used to assess and understand the extent of the knowledge in an emerging field or to identify, map, report, or discuss the characteristics or concepts in that field. The Joanna Briggs Institute (JBI) is an international research organisation based in the Faculty of Health and Medical Sciences at the University of Adelaide. The JBI develops and delivers evidence-based information, software, education, and training and its guidance is widely cited across a range of disciplines, academic fields, and professional backgrounds. This scoping review will follow the JBI process who recommend the PCC framework (‘Population–Concept–Context’) to frame the research question. The ‘Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for Scoping Reviews’ will be used to guide the reporting of this protocol and will also subsequently be used to structure the reporting of the full review (PRISMA-ScR). Dissemination: Findings will be presented to explore speciality-specific and profession-specific commonalities and differences. The scoping review results will be disseminated via publication in peer-reviewed journals (it is envisaged that at least two publications will be developed) and presentation at national/international conferences.

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“…As part of a scoping review, the senior author has discussed 1 the general indications for the intra-articular (IA) insertion of a needle into a joint: for diagnostic arthrocentesis or injection of a therapeutic medication(s) [2][3][4][5][6][7] . Therapeutic injections of corticosteroids provide a treatment option for patients with joint or peri-articular pain, and injection therapy (IT) is now one of the most common and widely performed interventions in musculoskeletal healthcare [8][9][10][11][12][13][14][15][16][17] , see Fig. 1 (patient of the senior author).…”

Section: Introductionmentioning

confidence: 99%

Use of Intra-Articular Injection Corticosteroid Injections to the First Metatarsophalangeal Joint. First Theme of a Scoping Review

Reilly¹,

Botchu²

2022

Preprint

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Introduction. A needle is inserted into a joint for arthrocentesis or injection of a therapeutic medication(s), commonly a corticosteroid. The aim of this paper is to discuss the first theme identified from a scoping review of corticosteroid injections for the pathology of the first metatarsophalangeal joint. Pathology. The two most common pathologies affecting the first metatarsophalangeal joint are osteoarthritis and bunions. An arthritic joint is regularly injected with a corticosteroid, but bunions are not. Other pathologies that may receive an injection include rheumatoid arthritis, gout, sesamoiditis and post-operative arthrofibrosis. Discussion. Most available evidence discusses corticosteroid injections for osteoarthritis, but there is a paucity of high-quality evidence, especially for corticosteroid use in other pathological conditions. Conclusion. Whilst the evidence base suggests that corticosteroid injections are safe short- and mid-term treatment options for a range of soft tissue and joint pathology, the specific indications, and short/long-term outcomes in the first metatarsophalangeal joint pathologies are not clear and warrant further study.

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Pharmacology for the Interventional Pain Physician

Cited by 9 publications

References 236 publications

A Bayesian Filtering Approach for Tracking Sympathetic Arousal and Cortisol-Related Energy From Marked Point Process and Continuous-Valued Observations

A Bayesian Filtering Approach for Tracking Sympathetic Arousal and Cortisol-Related Energy From Marked Point Process and Continuous-Valued Observations

Key concepts for intra-articular corticosteroid injections for pathology of the first metatarsophalangeal joint: a scoping review protocol

Use of Intra-Articular Injection Corticosteroid Injections to the First Metatarsophalangeal Joint. First Theme of a Scoping Review

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