Pharmacology and toxicology of tannins

Maugeri, Alessandro; Lombardo, Giovanni Enrico; Cirmi, Santa; Süntar, İpek; Barreca, Davide; Laganà, Giuseppina; Navarra, Michele

doi:10.1007/s00204-022-03250-0

Cited by 35 publications

(24 citation statements)

References 138 publications

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“…The authors proposed that the highest antiviral effect of EtOAc-Pp may be due to the condensed tannins, which are present only in this substance. Tannins are a class of polyphenols, characterized by having different molecular sizes and degrees of polymerization, which affect their pharmacokinetics and antiviral activity (Maugeri et al 2022 ). Condensed tannins have previously demonstrated antiviral activity against other viruses, such as the respiratory syncytial virus (RSV), influenza A virus (FLU-A), and parainfluenza virus (PIV) (Bruyne et al 1999 ).…”

Section: Natural Compounds As Inhibitors Of the Replicative Cycle Of ...mentioning

confidence: 99%

An update on the development of antiviral against Mayaro virus: from molecules to potential viral targets

et al. 2023

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Mayaro virus (MAYV), first isolated in 1954 in Trinidad and Tobago islands, is the causative agent of Mayaro fever, a disease characterized by fever, rashes, headaches, myalgia, and arthralgia. The infection can progress to a chronic condition in over 50% of cases, with persistent arthralgia, which can lead to the disability of the infected individuals. MAYV is mainly transmitted through the bite of the female Haemagogus spp. mosquito genus. However, studies demonstrate that Aedes aegypti is also a vector, contributing to the spread of MAYV beyond endemic areas, given the vast geographical distribution of the mosquito. Besides, the similarity of antigenic sites with other Alphavirus complicates the diagnoses of MAYV, contributing to underreporting of the disease. Nowadays, there are no antiviral drugs available to treat infected patients, being the clinical management based on analgesics and non-steroidal anti-inflammatory drugs. In this context, this review aims to summarize compounds that have demonstrated antiviral activity against MAYV in vitro, as well as discuss the potentiality of viral proteins as targets for the development of antiviral drugs against MAYV. Finally, through rationalization of the data presented herein, we wish to encourage further research encompassing these compounds as potential anti-MAYV drug candidates. Supplementary Information The online version contains supplementary material available at 10.1007/s00203-023-03441-y.

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Section: Natural Compounds As Inhibitors Of the Replicative Cycle Of ...mentioning

confidence: 99%

An update on the development of antiviral against Mayaro virus: from molecules to potential viral targets

et al. 2023

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“…As previously mentioned, the antioxidant capacities of tannins are of high importance for human health, providing neuroprotective, cardioprotective, and even antitumoral activities. In a recent review, Maugeri et al (2022) summarized the in vitro and in vivo effects of tannins in several experimental models and provided evidence of anti-bacterial and anti-inflammatory effects. It can be seen that the anti-inflammatory effects of tannins are related to palliating oxidative stress, reducing ROS and NOS, avoiding DNA damage, and taking part in some signaling routes ( Maugeri et al, 2022 ).…”

Section: Tannins and Their Properties: Antioxidants And Relationships...mentioning

confidence: 99%

“…In a recent review, Maugeri et al (2022) summarized the in vitro and in vivo effects of tannins in several experimental models and provided evidence of anti-bacterial and anti-inflammatory effects. It can be seen that the anti-inflammatory effects of tannins are related to palliating oxidative stress, reducing ROS and NOS, avoiding DNA damage, and taking part in some signaling routes ( Maugeri et al, 2022 ). In addition, the health benefits of tannins have been thoroughly reviewed elsewhere ( Basu et al, 2014 ; Cory et al, 2018 ; Lu et al, 2021 ).…”

Section: Tannins and Their Properties: Antioxidants And Relationships...mentioning

confidence: 99%

Regulation of Plant Tannin Synthesis in Crop Species

2022

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Plant tannins belong to the antioxidant compound family, which includes chemicals responsible for protecting biological structures from the harmful effects of oxidative stress. A wide range of plants and crops are rich in antioxidant compounds, offering resistance to biotic, mainly against pathogens and herbivores, and abiotic stresses, such as light and wound stresses. These compounds are also related to human health benefits, offering protective effects against cardiovascular and neurodegenerative diseases in addition to providing anti-tumor, anti-inflammatory, and anti-bacterial characteristics. Most of these compounds are structurally and biosynthetically related, being synthesized through the shikimate-phenylpropanoid pathways, offering several classes of plant antioxidants: flavonoids, anthocyanins, and tannins. Tannins are divided into two major classes: condensed tannins or proanthocyanidins and hydrolysable tannins. Hydrolysable tannin synthesis branches directly from the shikimate pathway, while condensed tannins are derived from the flavonoid pathway, one of the branches of the phenylpropanoid pathway. Both types of tannins have been proposed as important molecules for taste perception of many fruits and beverages, especially wine, besides their well-known roles in plant defense and human health. Regulation at the gene level, biosynthesis and degradation have been extensively studied in condensed tannins in crops like grapevine (Vitis vinifera), persimmon (Diospyros kaki) and several berry species due to their high tannin content and their importance in the food and beverage industry. On the other hand, much less information is available regarding hydrolysable tannins, although some key aspects of their biosynthesis and regulation have been recently discovered. Here, we review recent findings about tannin metabolism, information that could be of high importance for crop breeding programs to obtain varieties with enhanced nutritional characteristics.

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“…Scientists are increasingly aware of flavonoids and polyphenolic compounds, a type of secondary metabolite in plants [38]. These metabolites have been shown to have antioxidant, hepatoprotective, and other biological properties.…”

Section: Flavonoids and Phenolic Compoundsmentioning

confidence: 99%

A Review of Potential Hepatoprotective Compounds from Medicinal Plants

Nagarajan¹

2022

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Diseases of the liver are among the leading causes of death in humans around the world. A variety of factors, including alcoholism, hepatitis B and C, cirrhosis, and cancer, can contribute to the development of liver disease. Some liver diseases are treatable with medication, but others require surgery or a liver transplant. Hepatoprotective agents are substances that protect the liver from damage. It is the hope of the many researchers who are currently working on the development of new types of hepatoprotective agents that they will eventually be able to provide an adequate level of protection for individuals who are at an increased risk of developing liver disease. It is without a doubt that natural products can be valuable sources of drug leads. In the pharmaceutical industry, natural products have long been recognized as potential leads for the development of new medicines. The potential benefits of phytochemicals and their hepatoprotective mechanism understanding is a scientific challenging, but their importance has been largely unrecognized. This review discusses a wide range of hepatoprotective compounds derived from different plant sources. The study includes both extracts of medicinal plants and isolated compounds. It appears that these agents may be effective in protecting the liver against various insults, including viral hepatitis, alcohol-induced and drug-induced liver damage. Overall, this review provides an overview of some of the most promising hepatoprotective compounds from plant sources and suggests that further research is necessary to fully understand their potential health benefits.

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Pharmacology and toxicology of tannins

Cited by 35 publications

References 138 publications

An update on the development of antiviral against Mayaro virus: from molecules to potential viral targets

An update on the development of antiviral against Mayaro virus: from molecules to potential viral targets

Regulation of Plant Tannin Synthesis in Crop Species

A Review of Potential Hepatoprotective Compounds from Medicinal Plants

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