Pharmacology and Toxicology of Nepeta cataria (Catmint) Species of Genus Nepeta: A Review

Sharma, Ajay; Nayik, Gulzar Ahmad; Cannoo, Damanjit Singh

doi:10.1007/978-3-030-04408-4_13

Cited by 16 publications

(21 citation statements)

References 36 publications

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“…Apart from these N. cataria showed many biological activities, viz. anti-inflammatory, anti-nociceptive activity, antimicrobial, antifungal activity, antioxidant activity, anthelmintic activity, cytotoxic activity, felineattractant activity, insect repellent, insecticidal activity, nematicidal activity, spasmolytic, bronchodilatory activities and trypanocidal activity 94 .…”

Section: Traditional Usesmentioning

confidence: 99%

Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Ibrahim

Qayssar²,

Sardar³

et al. 2022

J. Drug Delivery Ther.

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Plant preparations are said to be medicinal or herbal when they are used to promote health beyond basic nutrition. It is indeed quite interesting to observe that our ancients were duly equipped with the vast, in depth and elaborated knowledge of drugs from the vegetable origin but unfortunately they possessed a scanty knowledge with regard to the presence of chemically pure compounds in most of them. The genus Nepeta L. (catmint), a large genus of the family Lamiaceae, is named after the ancient Italian City of Nephi It is also known as Glechoma and Cataria and it contains about 280 annual and perennial species, the majority of which are aromatic plants native to temperate Europe, Asia, North Africa, and North America. The wide variety and high content of terpenoid, flavonoid and phenolic compounds of Nepeta species provide diverse pharmacological effects, justifying its traditional utilization for medicinal purposes. Nepeta cataria (catnip or catmint, N. cataria), an aromatic perennial herb, belongs to genus Nepeta of Lamiaceae family and has been well known for its medicinal and therapeutic values. The name Cataria has been originated from Cathus, an old Latin word, which mean of cats. Like other aromatic plants which have showed flavoring and medicinal properties and act as renewable source for the same, N. cataria has also been known for its essential oil and secondary metabolites, which showed tremendous applications in pharmaceutical, agrochemical and food industries. It was shown by the different research groups that the essential oil and different extracts isolated from N. cataria have been a rich source of nepetalactones and related compounds (iridoids), which have been mainly responsible for different biological activities of the plant, viz. cat attractant, antioxidant, hepatoprotective, antidiabetic activities, as well as sedative, antidepressant, spasmolytic, anti-nociceptive and anti-inflammatory activities. Experiments show that this plant influences sexual activity, and expresses anticancer properties. Antimicrobial activity against a number of bacteria is also noted, as well as repellent and insecticidal properties. Nematodidal and allelopathic effects are also noted. This review emphasizes on latest information regarding the botany, distribution, cultivation taxonomy, traditional uses and more focused on phytochemistry, pharmacology.

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Section: Traditional Usesmentioning

confidence: 99%

Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Ibrahim

Qayssar²,

Sardar³

et al. 2022

J. Drug Delivery Ther.

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“…Nepeta cataria essential oil and metabolites have important applications in the pharmaceutical, agrochemical, and food industries (Sharma et al, 2021 ). Researchers found them to be antifungal, antibacterial (Bandh and Kamili, 2011 ; Sharma et al, 2019 ), antioxidant (Adiguzel et al, 2009 ), insecticidal, anti-inflammatory, anti-nociceptive, and potentially spasmolytic (Pargaien et al, 2020 ; Giarratana et al, 2017 ). Essential oils, flavonoids, phenolic acid, steroids, terpenoids, and terpenoid hydrocarbons have all been found in this plant.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling of antimicrobial and potential antioxidant plant: Nepeta cataria

Nadeem

Shahzad²,

Ahmed³

et al. 2022

Front. Plant Sci.

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Traditional and phytochemical studies have confirmed the richness and diversity of medicinal plants such as Nepeta cataria (N. cataria), but more studies are needed to complete its metabolite profiling. The objective of this research was to enhance the metabolomic picture and bioactivity of N. cataria for better evaluation. Phytochemical analysis was performed by bio-guided protocols and gas chromatography-mass spectrometry (GC/MS). For this, solvents such as methanol, ethanol, water, acetone, and hexane were used to extract a wide number of chemicals. Antibacterial analysis was performed using the 96-well plate test, Kirby Bauer's disk diffusion method, and the resazurin microdilution test. Antioxidant activity was determined by the DPPH assay and radical scavenging capacity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GC/MS analysis revealed a total of 247 identified and 127 novel metabolites from all extracts of N. cataria. Water and acetone extracts had the highest identified metabolites (n = 79), whereas methanol extract was the highest in unidentified metabolites (n = 48). The most abundant phytochemicals in methanol extract were 1-isopropylcyclohex-1-ene (concentration = 27.376) and bicyclo [2.2.1] heptan-2-one (concentration = 20.437), whereas in ethanol extract, it was 9,12,15-octadecatrienoic acid (concentration = 27.308) and 1-isopropylcyclohex-1-ene (concentration = 25.854). An abundance of 2 methyl indoles, conhydrin, and coumarin was found in water extracts; a good concentration of eucalyptol was found in acetone extract; and 7,9-di-tert-butyl-1-oxaspiro is the most abundant phytochemicals in hexane extracts. The highest concentration of flavonoids and phenols were identified in hexane and methanol extracts, respectively. The highest antioxidant potential (DPPH assay) was observed in acetone extract. The ethanolic extract exhibited a two-fold higher ORAC than the methanol extract. This examination demonstrated the inhibitory effect against a set of microbes and the presence of polar and non-polar constituents of N. cataria. The results of this study provide a safe resource for the development of food, agriculture, pharmaceutical, and other industrial products upon further research validation.

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“…It is represented in Turkey by 44 taxa, 20 of which are endemic [ 2 ]. Species belonging to the genus have different uses such as traditional medicine, agrochemical, and food additives [ 3 ]. It has been reported that the fresh or dried flowering top leaves of Nepeta cataria are used as flavoring agents in dishes, especially sauces, soups, and cheeses [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Species belonging to the genus have different uses such as traditional medicine, agrochemical, and food additives [ 3 ]. It has been reported that the fresh or dried flowering top leaves of Nepeta cataria are used as flavoring agents in dishes, especially sauces, soups, and cheeses [ 3 , 4 ]. Because of their antispasmodic, expectorant, diuretic, antiseptic, emenagogue, antitussive, antiasthmatic, anticonvulsant, sedative, diaphoretic, analgesic, antipyretic, antifungal, antiviral, anti-inflammatory, antihemorrhoidal, antirheumatic activities Nepeta species are commonly used to treat a variety of ailments in the regions where they grow [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effects of Some Nepeta Species against Breast Cancer Cell Lines and Their Associated Phytochemical Properties

Şafak

Karatoprak

Dırmencı

et al. 2022

Plants

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Nepeta is one of the largest genera of the Lamiaceae family. Nepeta species are commonly employed in traditional medicine for a variety of ailments, as well as food additives. In addition, they also come to the fore with their rich phytochemical content. In the present study, the quantitative phytochemical content of methanolic extracts and infusions prepared from the aerial parts of 14 Nepeta taxa collected from Turkey and their cytotoxic effects on two breast cancer cell lines, MCF-7 and MDA-MB-231, were investigated by using the MTT (3-(4,5-dimethylthiazol-2-yl))-2,5-diphenyltetrazolium-bromide) test. According to HPLC-PDA analysis, N. racemosa methanolic extract had the highest ursolic acid content with 165.9 mg/g extract. Total sterol, total iridoid, and total triterpenoid content were determined to be greatest in the methanolic extracts of N. meyeri, N. trichocalyx and N. phyllochlamys. The MTT experiment demonstrated that certain Nepeta species suppressed the growth of MCF-7 and MDA-MB-231 cells in a dose-dependent manner. Statistical analysis revealed a strong correlation between the cytotoxic effects of the extracts and their triterpene content. In conclusion, the data obtained from this study are important in terms of forming a basis for advanced anticancer activity studies on breast cancer with Nepeta sp.

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Pharmacology and Toxicology of Nepeta cataria (Catmint) Species of Genus Nepeta: A Review

Cited by 16 publications

References 36 publications

Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Phytochemical profiling of antimicrobial and potential antioxidant plant: Nepeta cataria

Cytotoxic Effects of Some Nepeta Species against Breast Cancer Cell Lines and Their Associated Phytochemical Properties

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