Pharmacology and Molecular Identity of Serotonin Receptor in Bivalve Mollusks

Alavi, Sayyed Mohammad Hadi; Nagasawa, Kazue; Takahashi, Keisuke; Osada, Makoto

doi:10.5772/intechopen.69680

Cited by 2 publications

(3 citation statements)

References 103 publications

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“…GPCRs have also been implicated in triggering the maturation of mollusc and annelid in response to serotonin (5-HT) [1,32]. A diversity of serotonin receptors and downstream pathways appears to be deployed across species [1,217]. These serotonin receptors are in a different GPCR superfamily from Clytia MIHR and have wider roles in reproductive regulation, with their role in maturation initiation likely redundant with other pathways, as shown in the nemertean Cerebratulus [36].…”

Section: Discussionmentioning

confidence: 99%

Managing the Oocyte Meiotic Arrest—Lessons from Frogs and Jellyfish

Jessus

Munro

Houliston

2020

Cells

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During oocyte development, meiosis arrests in prophase of the first division for a remarkably prolonged period firstly during oocyte growth, and then when awaiting the appropriate hormonal signals for egg release. This prophase arrest is finally unlocked when locally produced maturation initiation hormones (MIHs) trigger entry into M-phase. Here, we assess the current knowledge of the successive cellular and molecular mechanisms responsible for keeping meiotic progression on hold. We focus on two model organisms, the amphibian Xenopus laevis, and the hydrozoan jellyfish Clytia hemisphaerica. Conserved mechanisms govern the initial meiotic programme of the oocyte prior to oocyte growth and also, much later, the onset of mitotic divisions, via activation of two key kinase systems: Cdk1-Cyclin B/Gwl (MPF) for M-phase activation and Mos-MAPkinase to orchestrate polar body formation and cytostatic (CSF) arrest. In contrast, maintenance of the prophase state of the fully-grown oocyte is assured by highly specific mechanisms, reflecting enormous variation between species in MIHs, MIH receptors and their immediate downstream signalling response. Convergence of multiple signalling pathway components to promote MPF activation in some oocytes, including Xenopus, is likely a heritage of the complex evolutionary history of spawning regulation, but also helps ensure a robust and reliable mechanism for gamete production.

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Section: Discussionmentioning

confidence: 99%

Managing the Oocyte Meiotic Arrest—Lessons from Frogs and Jellyfish

Jessus

Munro

Houliston

2020

Cells

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“…Serotonin is a main actor in the neuroendocrine-immune regulation in marine bivalves, and it participates efficient responses to environmental stressors, including osmotic or temperature changes, acidification and pollution [see for review ref. (17)]. However, many other physiological functions of 5-HT have long been reported in bivalves and are shortly described below.…”

Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

“…Gametogenesis and spawning: serotonin is physiologically produced in the nervous system, and delivered through serotoninergic fibers identified in the mantle/gonads of several bivalve species (17). Accordingly, different reproductive events are regulated by 5-HT in bivalves.…”

Section: Pleiotropic Functions Of Serotonin In Bivalvesmentioning

confidence: 99%

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

et al. 2022

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Contaminants of Emerging Concerns (CECs) are defined as chemicals not commonly monitored in aquatic ecosystems, but with the potential to cause adverse effects on biota. CECs include Endocrine Disrupting Chemicals (EDCs) and Neuro-Endocrine disruptors (NEDs) of vertebrates. However, most invertebrates only rely on neuroendocrine systems to maintain homeostatic processes. Although conserved neuroendocrine components have been characterized in ecologically relevant groups, limited knowledge on invertebrate neuroendocrinology makes it difficult to define EDCs and NEDs in most species. The monoamine serotonin (5-hydroxytryptamine, 5-HT) acts both as a neurotransmitter and as a peripheral hormone in mammals. In molluscs, 5-HT is involved in multiple physiological roles and molecular components of the serotonergic system have been identified. This review is focused on the effects of CECs on the serotonergic system of bivalve molluscs. Bivalves are widespread in all aquatic environments, estuarine and coastal areas in particular, where they are exposed to a variety of chemicals. In bivalves, 5-HT is involved in gametogenesis and spawning, oocyte maturation and sperm motility, regulates heart function, gill ciliary beating, mantle/siphon function, the ‘‘catch’’ state of smooth muscle and immune responses. Components of 5-HT transduction (receptors and signaling pathways) are being identified in several bivalve species. Different CECs have been shown to affect bivalve serotonergic system. This particularly applies to antidepressants, among the most commonly detected human pharmaceuticals in the aquatic environment. In particular, selective serotonin reuptake inhibitors (SSRIs) are frequently detected in seawater and in bivalve tissues. Information available on the effects and mechanisms of action of SSRIs on the serotonergic system of adult bivalves is summarized. Data are also reported on the effects of CECs on development of neuroendocrine pathways of early larval stages, in particular on the effects of model EDCs in the marine mussel Mytilus galloprovincialis. Overall, available data point at the serotonergic system as a sensitive target for neuroendocrine disruption in bivalves. The results contribute drawing Adverse Outcome Pathways (AOPs) for model EDCs and SSRIs in larvae and adults. However, basic research on neuroendocrine signaling is still needed to evaluate the potential impact of neuroendocrine disruptors in key invertebrate groups of aquatic ecosystems.

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Pharmacology and Molecular Identity of Serotonin Receptor in Bivalve Mollusks

Cited by 2 publications

References 103 publications

Managing the Oocyte Meiotic Arrest—Lessons from Frogs and Jellyfish

Managing the Oocyte Meiotic Arrest—Lessons from Frogs and Jellyfish

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption

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