Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs

Poordad, Fred; Chee, Grace M.

doi:10.1002/9781444346343.ch5

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Ribavirin: More Than a Sidekick1

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2011

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“…As a single agent given to HCV patients, it had little effect on viral decline, but improved aminotransferases. It was approved for HCV in the late 1990s in combination with IFN-α [13].…”

Section: Ribavirin: More Than a Sidekickmentioning

confidence: 99%

Interferon Free Hepatitis C Treatment Regimens: The Beginning of Another Era

Poordad

Chee

2011

Curr Gastroenterol Rep

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Hepatitis C is a virus affecting millions worldwide and is a major health risk. With the potentially severe adverse event profile of the current backbone of therapy, interferon, there is an impetus to discover interferon free treatment regimens. With the development of new oral direct acting antivirals, interferon free regimens may be available in the next few years. This article discusses some of the preliminary data from interferon free studies.

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“…As a single agent given to HCV patients, it had little effect on viral decline, but improved aminotransferases. It was approved for HCV in the late 1990s in combination with IFN-α [13].…”

Section: Ribavirin: More Than a Sidekickmentioning

confidence: 99%