2012
DOI: 10.1007/978-3-642-30726-3_24
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Pharmacology and Clinical Use of Sex Steroid Hormone Receptor Modulators

Abstract: Sex steroid receptors are ligand-triggered transcription factors. Oestrogen, progesterone and androgen receptors form, together with the glucocorticoid and mineralocorticoid receptors, a subgroup of the superfamily of nuclear receptors. They share a common mode of action, namely translating a hormone-i.e. a small-molecule signal-from outside to changes in gene expression and cell fate, and thereby represent "natural" pharmacological targets.For pharmacological therapy, these receptors have originally been addr… Show more

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Cited by 29 publications
(16 citation statements)
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“…Subsequently, these complexes translocate to the nucleus where they trigger gene expression important for many physiological and pathophysiological functions and thus are targets for therapeutic strategies [1-3]. In contrast to the classical pathway where the hormonal effects appear after hours, many cell types display rapid hormone signaling upon steroid hormone stimulation mediated by receptors or ion channels located at the cell surface [4, 5].…”
Section: Introductionmentioning
confidence: 99%
“…Subsequently, these complexes translocate to the nucleus where they trigger gene expression important for many physiological and pathophysiological functions and thus are targets for therapeutic strategies [1-3]. In contrast to the classical pathway where the hormonal effects appear after hours, many cell types display rapid hormone signaling upon steroid hormone stimulation mediated by receptors or ion channels located at the cell surface [4, 5].…”
Section: Introductionmentioning
confidence: 99%
“…Вместе с тем на сегодняшний день доказано, что крат ковременная гормональная терапия не позволяет достичь эффективных результатов и особенно обеспечить долго срочную профилактику возрастных изменений [2,3].…”
Section: обзор литературных данныхunclassified
“…Many of the effects of aldosterone are adequately explained by the activation of the classical cytoplasmic and/or nuclear MR acting as a transcription factor. Further, some of the rapid effects of aldosterone may be mediated by cytoplasmic MR tethered to the plasma membrane The MR is member of the steroid hormone nuclear receptor subfamily . However, it has long been speculated that some of the effects of aldosterone are mediated by a membrane‐associated non‐MR‐linked pathway .…”
Section: Emerging Concept 2: the Differential Vascular Effects Of Aldmentioning
confidence: 99%
“…hormone nuclear receptor subfamily. 18,19 However, it has long been speculated that some of the effects of aldosterone are mediated by a membrane-associated non-MR-linked pathway. 20 This, in most part, was based on the insensitivity of these effects to inhibition by spironolactone.…”
Section: Emerging Concept 2: the Differential Vascular Effects Of Aldmentioning
confidence: 99%