Pharmacology and Clinical Use of Dimethyl Sulfoxide (DMSO): A Review

Patil, M. S.

doi:10.5376/ijmvr.2013.03.0006

Cited by 10 publications

(4 citation statements)

References 90 publications

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“…The aromatic groups in curcumin structure provide hydrophobicity, which makes it poorly soluble in water, while acetone, ethanol, and benzene are suitable solvents. The most widely used solvent is still DMSO [ 47 ]. The solubility of curcumin tautomers and its complexes (Cur-Enol, Cur-Anti-diketone, and Cur-Ni, Cur-Cu, and Cur-Mg) were investigated ( Table 8 and Figure 7 ).…”

Section: Resultsmentioning

confidence: 99%

Multitask Quantum Study of the Curcumin-Based Complex Physicochemical and Biological Properties

Baira

Ounissi

Merouani

et al. 2022

IJMS

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Density functional theory (DFT), time-dependent density functional theory (TDDFT), quantum theory of atoms in molecules (QTAIM), and extended transition state natural orbitals for chemical valence (ETS-NOCV) have all been used to investigate the physicochemical and biological properties of curcumin and three complexes, i.e., Cur-M (M = Ni, Cu, and Mg). Based on DFT calculations, the enolic form (Cur-Enol) is more stable than the anti-diketone form (Cur-Anti diketone) favored for complexation. This enolic form stability was explained by the presence of three intramolecular hydrogen bonds according to the QTAIM analysis. Furthermore, the ETS-NOCV technique revealed that the enolic form had more significant antioxidant activity compared with the anti-diketone form. The calculations from the COnductor-like Screening MOdel for Realistic Solvents (COSMO-RS) showed that the dimethyl sulfoxide (DMSO) solvent could dissolve all the curcumin tautomers Cur-Enol, Cur-Anti-diketone and Cur-Cu, Cur-Mg, and Cur-Ni complexes in contrast to benzene, acetone, octanol, ethanol, methanol, and water. Furthermore, except for Cur-Mg, which had a relatively low solubility (14 g/L), all complexes were insoluble in water. Cur-Anti-diketone was considerably more soluble than Cur-Enol in the examined solvents.

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Section: Resultsmentioning

confidence: 99%

Multitask Quantum Study of the Curcumin-Based Complex Physicochemical and Biological Properties

Baira

Ounissi

Merouani

et al. 2022

IJMS

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“…This manipulation allowed us to evaluate differences in glucocorticoid uptake and/or clearance, as well as negative feedback. DMSO is a polar solvent that has been used in veterinary and human medicine as a delivery vehicle for topical application of lipophilic compounds for decades (Kumar and Darreh-Shori, 2017; Patil, 2013). It is considered non-toxic, though it can have off-target cellular effects such as inhibition of acetylcholinesterase, and is used by itself for a variety of conditions to reduce inflammation (Santos et al, 2003).…”

Section: Methodsmentioning

confidence: 99%

“…We removed the chick to take a second blood sample 15 min after the first sample (i.e., 30 min after gel treatment), to evaluate the effect of exogenous corticosterone on subsequent endogenous corticosterone production in response to handling during bleed #1. Finally, though DMSO is estimated to take at least 5 minutes to penetrate the skin and enter the bloodstream (Patil 2013), nothing is known about the acute time course of corticosterone uptake from topical DMSO application in young seabird chicks. Therefore we checked for very rapid changes in corticosterone by treating a small subset of chicks with topical CORT or DMSO and taking a single blood sample 5 minutes after treatment administration (Table 2).…”

Section: Experiments 2: Effects Of Exogenous Corticosterone On Endoge...mentioning

confidence: 99%

Corticosterone release in very young siblicidal seabird chicks (Rissa tridactyla) is sensitive to environmental variability and responds rapidly and robustly to external challenges

Benowitz-Fredericks,

Will,

Pete

et al. 2024

Preprint

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In birds, patterns of development of the adrenocortical response to stressors vary among individuals, types of stressors, and species. Since there are benefits and costs of exposure to elevated glucocorticoids, this variation is presumably a product of selection such that animals modulate glucocorticoid secretion in contexts where doing so increases their fitness. In this study, we evaluated hypothalamic-pituitary-adrenal (HPA) activity in first-hatched free-living seabird nestlings (black-legged kittiwakes,Rissa tridactlya) at a critical early age when food availability may drive the establishment of important parent-offspring and intra-brood dynamics. We experimentally supplemented parents with food (fed) and measured chick baseline corticosterone secretion at 5 days post-hatch (of the ~45 day nestling period) and capacity to rapidly increase corticosterone in response to an acute challenge (handling and a 15 min restraint in a bag). We also used topical administration of corticosterone to evaluate the ability of chicks to downregulate physiologically relevant corticosterone levels on a short (minutes) time scale. We found that 5 day old chicks are capable of releasing corticosterone in proportion to the magnitude of the challenge, showing differences in baseline between parental feeding treatments (supplementally-fed vs control), moderate increases in response to handling, and a larger response to restraint (comparable to restraint-induced levels found in adults) that also differed between chicks from fed and control nests. The topical application of exogenous corticosterone resulted in an increase of circulating levels similar to the restraint-induced levels. The corticosterone application also induced the downregulation of HPA responsiveness to the acute challenge of handling. Parental supplemental feeding did not affect absorbance/clearance or negative feedback. Thus, while endogenous secretion of corticosterone in 5 day old chicks is sensitive to environmental context, other aspects of the HPA function, such as rapid negative feedback and/or the ability to clear acute elevations in corticosterone, are not. We conclude that 5 day old kittiwake chicks are capable of robust adrenocortical responses to novel challenges, and are sensitive to parental food availability, which may be transduced behaviorally, nutritionally, or via maternal effects. Questions remain about the function of such rapid, large acute stress-induced increases in corticosterone in very young chicks.

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“…Due to the very low water solubility of FF (approximately 1.3 mg/mL), these organic solvents are commonly used to afford FF solubility in commercial formulations. They are dipolar aprotic solvents with low toxicity and often simultaneously act as co-solvents and complexing agents in veterinary drug formulations (Strickley, 2004;Jouyban et al, 2010;Patil and Shivaprakash, 2013). However, their difference in the mechanism of action and molecular structures manifested in the larger planar nonpolar region of N-methyl-2-pyrrolidone may have some impact on the API delivery system (Williams and Barry, 2012).…”

Section: Ff In the Plasma Of Treated Pigsmentioning

confidence: 99%

Analysis of florfenicol in pig plasma using a validated PPT-HPLC-DAD method

Šandor

Terzić²,

Mihaljević

et al. 2022

Vet. stn. (Online)

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High performance liquid chromatography (HPLC) has proven to be an effective tool for examining the disposition kinetics of florfenicol (FF), a synthetic broad-spectrum antibiotic used to treat infectious diseases in veterinary medicine. Modification and optimisation of the protein precipitation (PPT) sample preparation procedure and HPLC with diode array detector (DAD) instrumental method were carried out to ensure conditions suitable for FF analyses in pig plasma samples. Stable supernatants with good plasma mean recoveries of FF (99.8% ± 0.7%RSD) were achieved using 1% v/v phosphoric acid solution in methanol and 10% w/v sodium chloride in aqueous solution. The PPT-HPLCDAD method’s detection limit of 0.004 μg/mL and quantification limit of 0.013 μg/mL provides high sensitivity for analyses of FF in plasma samples. In addition, the optimisation of method conditions resulted in shorter extraction and analysis time and less solvent consumption, which stresses the sustainability of this method in analytical chemistry. The optimised and validated PPT-HPLC-DAD method was applied in a comparative study of FF in pig plasma after administration of veterinary medicinal products. The study was conducted on fattening pigs following repeated intramuscular administration of two similar solutions for injection at a dose of 20 mg FF/kg bodyweight (test groups 1 and 2). The solutions for injection contained the same FF concentration, i.e., 300 mg/mL, but differed in excipients. The aim was to examine the influence of administrated solutions for injection on the extent of exposure to FF in pig plasma. The dynamics of kinetic profiles of FF in pig plasma from both treatments correspond to the FF kinetic profiles published in similar studies. However, differences were observed in the concentrations of FF, which were constant throughout the study, and statistical differences between the test groups were confirmed (P<0.05). Though these findings suggest the possible influence of excipients, a full comprehensive conclusion on the influence of administrated solutions for injection on FF exposure in pig plasma requires additional research.

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Pharmacology and Clinical Use of Dimethyl Sulfoxide (DMSO): A Review

Cited by 10 publications

References 90 publications

Multitask Quantum Study of the Curcumin-Based Complex Physicochemical and Biological Properties

Multitask Quantum Study of the Curcumin-Based Complex Physicochemical and Biological Properties

Corticosterone release in very young siblicidal seabird chicks (Rissa tridactyla) is sensitive to environmental variability and responds rapidly and robustly to external challenges

Analysis of florfenicol in pig plasma using a validated PPT-HPLC-DAD method

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