Pharmacology

doi:10.5772/2218

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…It is characterized by being a volatile fraction constituted mainly by monoterpenes and sesquiterpenes. The terpenes, which constitute the non-volatile fraction of these resins, are mainly diterpenic acids with three molecular skeletons of the abietane, pimaran and labdan type, varying quantitatively among the different families of conifers [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Obtaining salts of resin acids from Cuban pine by metathesis reactions

2020

Biointerface Res Appl Chem

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The resin acids obtained from the Cuban pine rosin are the starting material for the development and application of metathesis reactions. These reactions allow the obtaining of salts with high added value which could be used in the development of biomaterials for dental use. The objective of this work was to obtain calcium, magnesium and zinc resinates from the resin acid obtained from the Cuban pine resin by metathesis reaction for possible use in the development of biomaterials. The products obtained were evaluated by elemental analysis, X-ray powder diffraction, infrared spectroscopy, scanning electron microscopy associated with electron dispersion spectroscopy, nuclear magnetic resonance and biological tests (antibacterial activity). The results showed the formation of the different resinates, observing the presence of cations in the salts obtained. The disappearance of the signal corresponding to the hydrogen of the carboxyl group was verified by nuclear magnetic resonance analysis due to the reaction between the resinic acid and the different metals studied. The biological analyzes showed that the best results are achieved with zinc resinate.

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Section: Introductionmentioning

confidence: 99%

“…This process is known as metathesis reaction [9,10]. Previous studies demonstrated the feasibility of obtaining resin acid from rosin from pine (var caribbaea) from the western part of Cuba [2,11].…”

Section: Introductionmentioning

confidence: 99%

Obtaining salts of resin acids from Cuban pine by metathesis reactions

2020

Biointerface Res Appl Chem

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Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain

Nagase

Akiyama

Nakajima

et al. 2012

Bioorganic & Medicinal Chemistry Letters

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Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1

Connick

Reed

Cawley

et al. 2021

Biochemical Journal

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P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when compared with P450 and HO-1, they must effectively compete for POR to function. In addition to these functionally required protein–protein interactions, HO-1 forms homomeric complexes, and several P450s have been shown to form complexes with themselves and with other P450s, raising the question, ‘How are the HO-1 and P450 systems organized in the endoplasmic reticulum?’ Recently, CYP1A2 was shown to associate with HO-1 affecting the function of both proteins. The goal of this study was to determine if CYP1A1 formed complexes with HO-1 in a similar manner. Complex formation among POR, HO-1, and CYP1A1 was measured using bioluminescence resonance energy transfer, with results showing HO-1 and CYP1A1 form a stable complex that was further stabilized in the presence of POR. The POR•CYP1A1 complex was readily disrupted by the addition of HO-1. CYP1A1 also was able to affect the POR•HO-1 complex, although the effect was smaller. This interaction between CYP1A1 and HO-1 also affected function, where the presence of CYP1A1 inhibited HO-1-mediated bilirubin formation by increasing the KmPOR•HO-1 without affecting the Vmaxapp. In like manner, HO-1 inhibited CYP1A1-mediated 7-ethoxyresorufin dealkylation by increasing the KmPOR•CYP1A1. Based on the mathematical simulation, the results could not be explained by a model where CYP1A1 and HO-1 simply compete for POR, and are consistent with the formation of a stable CYP1A1•HO-1 complex that affected the functional characteristics of both moieties.

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Pharmacology

Cited by 4 publications

References 17 publications

Obtaining salts of resin acids from Cuban pine by metathesis reactions

Obtaining salts of resin acids from Cuban pine by metathesis reactions

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain

Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1

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