Pharmacologically Active Secondary Metabolites from Wood

Beecher, Christopher W.W.; Farnsworth, Norman R.; Gyllenhaal, Charlotte

doi:10.1007/978-3-642-74075-6_31

Cited by 7 publications

(2 citation statements)

References 507 publications

(12 reference statements)

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“…Lignans are of great interest in the search for novel agents with antioxidant and antitumor effects, and have potential for cancer chemoprevention (Nishibe 1997;Ward 1997;Ford et al 1999;Saarinen et al 2000;Hoikkala et al 2001;Umezawa 2001). Stilbenes, typical for Pinus spp., and flavonoids may also have bioactive and pharmacological effects (e.g., Rennerfelt and Nacht 1955;Hart 1981Hart , 1989Beecher et al 1989;Norin 1989;Harborne 1989;Nishibe 1997;Bohm 1998;Fisher et al 2001;Umezawa 2001). Stilbenes, typical for Pinus spp., and flavonoids may also have bioactive and pharmacological effects (e.g., Rennerfelt and Nacht 1955;Hart 1981Hart , 1989Beecher et al 1989;Norin 1989;Harborne 1989;Nishibe 1997;Bohm 1998;Fisher et al 2001;Umezawa 2001).…”

Section: Introductionmentioning

confidence: 99%

Phenolic and Lipophilic Extractives in Scots Pine Knots and Stemwood

Willför¹,

Hemming²,

Reunanen³

et al. 2003

Holzforschung

140

104

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The phenolic and lipophilic extractives in the heartwood of knots from seven Scots pine trees were analysed by GC, GC-MS and HPSEC. The knots contained large amounts of phenolic stilbenes, 1-7% (w/w), and lignans, 0.4-3% (w/w), while the stemwood contained around 1% (w/w) of stilbenes and no detectable lignans. In young trees without stem heartwood the stilbene content in the knots was up to 200 times that in the stem. Some in-tree and between-tree variation was seen in the content of phenolic compounds in the knots. The ratio of pinosylvin monomethyl ether to pinosylvin was higher in the knots than in the stemwood. The most abundant lignan was nortrachelogenin, but also matairesinol, secoisolariciresinol and liovil were present in small amounts in the knots. The knots also contained a complex mixture of lignan-like compounds, here called oligolignans. The flavonoid pinocembrin was present in both stemwood and knots in amounts below 0.02% (w/w). The stilbene concentration in the radial direction, from the pith to the outer branch, decreased or was on the same level inside the stem, while it decreased markedly in the outer branch. The lignan concentration was on the same level or decreased slightly inside the stem, while it decreased markedly in the branches and became almost non-existent within 10 cm out in the branches. The knots contained large amounts (4.5-32% (w/w)) of lipophilic extractives, mainly resin acids. Some in-tree and between-tree variation was seen for the resin acids. The abietanetype resin acids dominated over the pimarane-type acids and abietic acid was the most abundant resin acid in the knots and in stem heartwood. The amount of resin acids in the radial direction decreased or was on the same level inside the stem, while a clear decrease was detected in the branches. The profile of the distribution of resin acids and phenolic compounds was similar. The knots also contained up to 0.5% (w/w) of diterpenyl aldehydes.

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Section: Introductionmentioning

confidence: 99%

Phenolic and Lipophilic Extractives in Scots Pine Knots and Stemwood

Willför¹,

Hemming²,

Reunanen³

et al. 2003

Holzforschung

140

104

View full text Add to dashboard Cite

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“…These drugs include several anticancer agents such as podophyllotoxin, paclitaxel, camptothecin, or compounds based on these as lead structures; each of these classes of compounds exhibit their anticancer activity by distinct mechanisms (3). It has been estimated that in the United States, 25% of all prescriptions dispensed from community pharmacies during the period contained plant extracts or active principles derived therefrom (4). Even now, 75-80% of the world population depends on crude plant drug preparations to treat their health problems, although this may be mostly because of economic considerations.…”

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confidence: 99%

Ancient-Modern Concordance in Ayurvedic Plants: Some Examples

Dev¹

2001

Development of Plant-Based Medicines: Conservation, Efficacy and Safety

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Ayurveda is the ancient (before 2500 BLC.) Indian sytem of health care and longvity. It involves a holistic view of man, his health, and illness. Ayurvedic treatment of a disease consists of salubrious use of drugs, diets, and certain practices. Medicinal preparations are invariably complex mixtures, based mosdy on plant products. Around 1,250 plants are currently used in various Ayurvedic preparations. Many Indian medicinal plants have come under scientdfic scrutiny since the middle of the nineteenth century, although in a sporadic fashion. The first significant contibution from Ayurvedic materia medica came with the isolation of the hypertesive alkaloid from the sarpgdha plant (Rauwo4Sa srpentina), valued in Ayurveda for the treatment of hypertension, mnia, and insanity. This was the first important ancient-modem concordance in Ayurvedic plants. With the gradual coming of age of chemistry and biology, disciplines central to the study of biologic activities of natural products, many Ayurvedic plants have been reinvestigated. Our work on Commiphora wighti gum-resin, valued in Ayurveda for correcting lipid disorders, has been described in some detail; based on these investigations, a modem antihyperlipoproteinemic drg is on the market in India and some other countries.

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Emerging Trends in Sustainable Bioprospecting of Bioresources

Purkayastha

2016

Bioprospecting of Indigenous Bioresources of North-East India

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Pharmacologically Active Secondary Metabolites from Wood

Cited by 7 publications

References 507 publications

Phenolic and Lipophilic Extractives in Scots Pine Knots and Stemwood

Phenolic and Lipophilic Extractives in Scots Pine Knots and Stemwood

Ancient-Modern Concordance in Ayurvedic Plants: Some Examples

Emerging Trends in Sustainable Bioprospecting of Bioresources

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