Pharmacologically active salts and ionic liquids based on 2-hydroxyethylamines, arylchalcogenylacetic acids, and essential metals

Мирскова, А. Н.; Адамович, С. Н.; Мирсков, Р. Г.; Воронков, М. Г.

doi:10.1007/s11172-014-0679-3

Cited by 30 publications

(10 citation statements)

References 61 publications

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“…In drug delivery, PILs are used in membrane transport due to the tuneable degree of ionicity. However, to the best of our knowledge, only a few studies have been dedicated to synthesise PILs with specific biological applications [11][12][13]. In this study, salicylic acid was used as the anion based PILs for potential antioxidant.…”

Section: -2506mentioning

confidence: 99%

Salicylate-Based Protic Ionic Liquids as a Potential Antioxidant

2019

MJAS

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Salicylate-based protic ionic liquids (PILs) were synthesised, characterised and assessed in this study for potential antioxidant in drug design. The synthesised PILs were known as 3-dimethylamino-1-propanol salicylate (3DMAPS) and 3-diethylamino-1propanol salicylate (3DEAPS). Proton nuclear magnetic resonance ( 1 HNMR), Fourier transformation infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) were used to characterise the synthesised PILs. Furthermore, the antioxidant activity of the synthesised PILs was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. Both 3DMAPS and 3DEAPS showed a good antioxidant activity compared to parent acid (salicylic acid) as these two compounds could scavenge 20% of DPPH free radical at a concentration of 66.76 ± 0.09 µM and 27.27 ± 0.10 µM, respectively. AbstrakCecair ionik protik (PILs) berasaskan salisilat disintesis, dicirikan dan dinilai untuk potensi antioksidan dalam reka bentuk dadah. Dua PILs iaitu 3-dimetilamino-1-propanol salisilat (3DMAPS) dan 3-diethilamino-1-propanol salisilat (3DEAPS) telah berjaya disintesis. Proton resonans magnetik nuklear ( 1 HNMR), spektroskopi transformasi inframerah (FTIR) dan analisis termogravimetrik (TGA) digunakan untuk pencirian PIL yang di sintesis. Tambahan pula, aktiviti antioksidan PIL ditentukan dengan menggunakan ujian radikal bebas 2,2-difenil-1-pikrilhidrazil (DPPH). Kedua-dua 3DMAPS dan 3DEAPS menunjukkan aktiviti antioksidan yang baik berbanding dengan asid induk (asid salisilat) kerana kedua-dua sebatian ini boleh membakar 20% radikal bebas DPPH masing-masing pada kepekatan 66.76 ± 0.09 μM dan 27.27 ± 0.10 μM.Kata kunci: cecair ionic protik, asid salisilik, perangkap radikal, radikal bebas, ujian DPPH

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Section: -2506mentioning

confidence: 99%

Salicylate-Based Protic Ionic Liquids as a Potential Antioxidant

2019

MJAS

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“…В данном контексте перспективны синтезированные нами доступные физиологически активные соединения -протатраны [5][6][7][8][9][10][11][12]. В качестве основы для дизайна протатранов выбраны два вида доступных реактивов (компонентов): биогенные этаноламины (в частности, триэтаноламин) и биологически активные арилхалькогенилуксусные кислоты.…”

Section: Introductionunclassified

Protatrans as biomodulators of <i>Candida ethanolica</i> growth

Кирюхина¹,

Лозовая²,

Privalova³

et al. 2020

Izvestiâ vuzov. Prikladnaâ himiâ i biotehnologiâ

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This study was aimed at investigating compounds from a series of protatranes as biostimulants for the growth of the Candida ethanolica yeast. The relevance of the study is associated with the need to determine conditions accelerating the growth of microorganisms in the presence of such highly effective, physiologically active and non-toxic compounds as protatranes. The research object was the Candida ethanolica yeast cultivated on a synthetic nutrient medium containing 1.5% ethanol solution as a carbon source. Protatrans were used at concentrations of 1·10-6 – 1·10-8 wt%. The number of yeast cells was controlled by determining the optical density of yeast suspensions using a KFK-3 Zomax photoelectrocolorimeter at a wavelength of 540 nm and optical path length of 10 mm. The determination of yeast biomass was carried out gravimetrically. The first stage of the work set out to study the accumulation of cells and biomass at various initial yeast cell concentrations. It was revealed that a slight increase in the initial concentration of yeast cells leads to a noticeable shift of the entire S-curve to the left. A comparison of the obtained data sets showed that the investigated protatranes significantly increase the specific growth rate and reduce the generation time during the log phase, provided that this phase accounts for a significant part of the cultivation process. However, the presence of protatranes significantly reduce the specific growth rate and increase the generation period in the log phase, provided that the culture remains in the stationary phase for a significant part of the cultivation time. This is likely to be associated with the positive effect of protatranes on protein synthesis, which is most intense during the log phase. The use of protatranes facilitates the control over the number of cells, amount of biomass, specific growth rate and generation time of the Candida ethanolica yeast depending on the initial cell concentration and, accordingly, the growth phase of the culture.

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“…In light of this, the chemical compounds synthesized at the Irkutsk institute of chemistry SB RAS can be considered as potential such materials. In particular, numerous tris-(2 hydroxyethyl) ammonium arylchalcogenylacetates, so-called “protatranes”, attract special interest [[17], [18], [19], [20]].…”

Section: Introductionmentioning

confidence: 99%

Protatranes, effective growth biostimulants of hydrocarbon-oxidizing bacteria from Lake Baikal, Russia

Pavlova

Адамович

Novikova

et al. 2019

Biotechnology Reports

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Highlights We have synthesized a wide range of tris-(2-hydroxyethyl)ammonium arylchalcogenylacetates, “protatranes”. “Protatranes” are growth stimulators of hydrocarbon-oxidizing Rhodococcus erythropolis bacteria isolated from Lake Baikal. The effect of “protatranes” on growth of Pseudomonas fluorescens is less obvious. The effect of stimulants on Rhodococcus erythropolis is likely due to the structure of protatranes and the cell wall of bacteria.

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Pharmacologically active salts and ionic liquids based on 2-hydroxyethylamines, arylchalcogenylacetic acids, and essential metals

Cited by 30 publications

References 61 publications

Salicylate-Based Protic Ionic Liquids as a Potential Antioxidant

Salicylate-Based Protic Ionic Liquids as a Potential Antioxidant

Protatrans as biomodulators of <i>Candida ethanolica</i> growth

Protatranes, effective growth biostimulants of hydrocarbon-oxidizing bacteria from Lake Baikal, Russia

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