Pharmacological treatments of presbyopia: a review of modern perspectives

Renna, Antonio; Alió, Jorge L.; Vejarano, L. Felipe

doi:10.1186/s40662-017-0068-8

Cited by 27 publications

(31 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Romano and Lograno [13] compared the effects of bimatoprost with the commonly prescribed PGs, latonoprost and travoprost, on human ciliary muscle contraction, and agreed with previous studies [14–19] that PGs might induce pseudomyopia. In contrast, pilocarpine, brimonidine, alpha agonists, and anti-inflammatory agents reduce presbyopia [20–25].…”

Section: Introductionmentioning

confidence: 99%

Latanoprost could exacerbate the progression of presbyopia

Ayaki¹,

Tsuneyoshi²,

Yuki³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

PurposeProstaglandin analogues (PG) reduce intra-ocular pressure by enhancing uveoscleral flow at the ciliary body, which controls accommodation via the ciliary muscle. We investigated the effect of PG on accommodation and presbyopia progression in glaucoma patients.MethodsWe conducted a clinic-based, retrospective, cross-sectional study. Inclusion criteria were bilateral phakic patients aged 40–69 years with best corrected visual acuity better than 20/30. Exclusion criteria were any disease affecting vision other than glaucoma and history of ocular surgery. Subjects with no prescription or vision-affecting disease served as controls (n = 260). The glaucoma patients were prescribed eye drops containing 0.005% latanoprost for more than six months (n = 23). We measured the binocular near add power at a distance of 30 cm in both groups and compared the results using Kaplan-Meier analysis.ResultsThe mean age (± SD) of the control subjects was 51.5 ± 5.2 years and 39% were male. Similarly, the glaucoma patients had a mean age of 51.0 ± 7.2 years and 39% were male. There were no significant differences in age, gender, intra-ocular pressure, spherical equivalent, astigmatism, or anisometropia between groups. Survival analysis indicated that the glaucoma patients in this study reached the endpoint (near add power of +3.00 D) significantly earlier than control patients (P = 0.0001; generalized Wilcoxon test).ConclusionsExacerbation of presbyopia progression in glaucoma patients is a potential side effect of latanoprost eyedrops.

show abstract

Section: Introductionmentioning

confidence: 99%

Latanoprost could exacerbate the progression of presbyopia

Ayaki¹,

Tsuneyoshi²,

Yuki³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…As such, several classes of eyedrops that address presbyopia are being developed or are currently under clinical evaluation. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Correction of presbyopia: An integrated update for the practical surgeon

Balgos

Vargas

Alió

2018

Taiwan J Ophthalmol

View full text Add to dashboard Cite

Presbyopia results from loss or insufficiency of the eye's accommodative ability, and clinically manifests as the inability to focus near objects on the retina. It is one of the most common causes of visual impairment worldwide especially in adults of productive or working age. Various means of compensating for the loss of accommodative ability have been devised from optical tools such as spectacles and contact lenses, to topical medications and to surgical procedures. A comprehensive search on journal articles about topical and surgical correction of presbyopia was undertaken. The various techniques for presbyopia correction, as enumerated in these articles, are discussed in this paper with the addition of our personal experience and perspective on the future of these techniques.

show abstract

“…However, light from the mid-periphery will still be blocked from entering the eye, [62][63][64][65][66] and total peripheral field occlusion can only be avoided by employing an annular 'iris', which for large field angles allows light to enter the eye around the outside of the inlay. 63 These field constriction problems can be avoided by placing the pinhole pupil into or very close to the iris plane (for example, by employing pharmacological miotics), [67][68][69][70] or including a small aperture into the anterior surface of an intraocular lens (IOL), 55,57,71 or piggy-back implantation of a pinhole aperture. 72 Selection of pinhole pupil size is affected by many factors, but a balance must be struck between improving the defocused near vision without compromising focused distance vision.…”

Section: Small Aperture Opticsmentioning

confidence: 99%

Correction of presbyopia: old problems with old (and new) solutions

Kollbaum

Bradley

2020

Clinical and Experimental Optometry

View full text Add to dashboard Cite

We live in a three‐dimensional world and the human eye can focus images from a wide range of distances by adjusting the power of the eye's lens (accommodation). Progressive senescent changes in the lens ultimately lead to a complete loss of this ability by about age 50, which then requires alternative strategies to generate high‐quality retinal images for far and close viewing distances. This review paper highlights the biomimetic properties and underlying optical mechanisms of induced anisometropia, small apertures, dynamic lenses, and multi‐optic lenses in ameliorating the visual consequences of presbyopia. Specifically, the advantages and consequences of non‐liner neural summation leveraged in monovision treatments are reviewed. Additionally, the value of a small pupil is quantified, and the impact of pinhole pupil location and their effects on neural sensitivity are examined. Different strategies of generating multifocal optics are also examined, and specifically the interaction between ocular and contact or intraocular lens aberrations and their effect on resulting image quality are simulated. Interestingly, most of the novel strategies for aiding presbyopic and pseudophakic eyes (for example, monovision, multifocality, pinhole pupils) have emerged naturally via evolution in a range of species.

show abstract

Pharmacological treatments of presbyopia: a review of modern perspectives

Cited by 27 publications

References 5 publications

Latanoprost could exacerbate the progression of presbyopia

Latanoprost could exacerbate the progression of presbyopia

Correction of presbyopia: An integrated update for the practical surgeon

Correction of presbyopia: old problems with old (and new) solutions

Contact Info

Product

Resources

About