Pharmacological Treatments for GH-Induced Insulin Resistance

Abstract

Abstract. Troglitazone (T) and d-chiroinositol (DCI) have been reported to improve insulin resistance associated with obesity and NIDDM. We tested whether these compounds counteract the insulin antagonistic effects of recombinant human GH. Male Wistar rats were allocated to 4 different treatment groups, rhGH (n=8), rhGH+T (n=7), rhGH+DCI (n=8) and control (saline, n=8). rhGH (2 IU/100 g/day) was injected sc twice daily for 2 days. T and DCI were given (20 mg/day) po for 5 days preceding and 2 days along with rhGH. Euglycemic hyperinsulinemic clamp studies were done to assess the hepatic glucose output (HGO) and glucose disappearance rate (GDR). Fasting plasma glucose, insulin, serum FFA and basal HGO were similar in all 4 treatment groups. During the hyperinsulinemic clamp which raised plasma insulin levels to 7.2 ± 0.4 ng/ml, HGO was suppressed in the control and rhGH+T treated rats but not in the rats treated with rhGH and rhGH+DCI. GDR decreased in the rats which received rhGH (18.1 ± 5.8 vs 30.3 ± 5.2 mg/kg/min) compared to the control rats. The rats given either T (24.7 ± 2.7) or DCI (31.4 ± 2.7) along with rhGH showed comparable GDR to the control rats. These results indicated that rhGH induced hepatic and peripheral insulin resistance. Troglitazone counteracted the insulin-antagonistic action of rhGH both in the liver and the peripheral tissues. DCI was effective in offsetting peripheral insulin resistance but without any effect on hepatic insulin resistance associated with rhGH treatment.

ChemInform Abstract: The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo‐Inositol Chemistry)

“…[117] Male Wistar rats suffering from insulin resistance induced by recombinant human growth hormone were treated with d-chiro-inositol, which offset the peripheral insulin resistance but not the hepatic insulin resistance. [118] Glucosamine induces peripheral and hepatic insulin resistance in rats,but pretreatment with d-chiro-inositol prevented the induced peripheral insulin resistance. [119] In mice suffering from streptozotocin-induced diabetes,chronic treatment with d-chiro-inositol prevents autonomic and somatic neuropathy.…”

Electrochemical behavior of poly(3-hexylthiophene). Controlling factors of electric current in electrochemical oxidation of poly(3-hexylthiophene)s in a solution

“…Regio-random poly(3-hexylthiophene), P3HexTh(Fe), [15]. Regio-regular head-to-tail type poly(3-hexylthiophene), HT-P3HexTh(Zn/Ni), which was prepared via organometallic polycondensation using a zinc compound and nickel complex [16], was purchased from Rieke Metals Inc. P3HexTh(Fe) and HT-P3HexTh(Zn/Ni) were fractionated into several parts with different M n (number average molecular weight) and M w (weight average molecular weight) values, according to solubility of the polymers in chloroform (solubility ¼ high), methylene chloride (solubility ¼ medium), THF (solubility ¼ medium), hexane (solubility ¼ low), and methanol (solubility ¼ poor) [17], in manners similar to that previously applied [18].…”

The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances inmyo‐Inositol Chemistry)

“…[117] Male Wistar rats suffering from insulin resistance induced by recombinant human growth hormone were treated with Dchiro-inositol which offset the peripheral insulin resistance but not the hepatic insulin resistance. [118] Glucosamine induces peripheral and hepatic insulin resistance in rats, but pre-treatment with D-chiro-inositol prevented the induced peripheral insulin resistance. [119] In mice suffering from streptozotocin-induced diabetes chronic treatment with D-chiroinositol prevents autonomic and somatic neuropathy.…”