Pharmacological treatment strategies of pterygium: Drugs, biologics, and novel natural products

Baheran, Sanaz Sadig; Alany, Raid G.; Schwikkard, Sianne; Muen, Wisam J.; Salman, Lena Namaan; Freestone, Nicholas; Al-Kinani, Ali A.

doi:10.1016/j.drudis.2022.103416

Cited by 9 publications

(5 citation statements)

References 95 publications

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“…Conjunctival injections can occasionally lead to local irritation, hemorrhages, necrosis, and granuloma at the injection site. 33 , 34 In our experiment, the only adverse reaction observed at MDSCs administration was conjunctival bleeding on one eye, which resolved within 1 week.…”

Section: Methodsmentioning

confidence: 49%

Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation

Lee,

Kim,

Sohn

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To evaluate the immune regulatory effect of human cord blood myeloid-derived suppressor cells (MDSCs) in experimental autoimmune uveitis (EAU) models. Methods MDSCs (1 × 10 6 ) or PBS were injected into established C57BL/6 EAU mice via the subconjunctival route on days 0 and 7. The severity of intraocular inflammation was evaluated for up to 3 weeks. Tissue injury and inflammation were analyzed using immunolabelled staining, real-time PCR, and ELISA. In addition, immune cells in draining lymph nodes (LNs) were quantified using flow cytometry. Results After 21 days, the clinical scores and histopathological grades of EAU were lower in the MDSCs group compared with the PBS group. Local administration of MDSCs suppressed the oxidative stress and the expression of TNF-α and IL-1β in the retinal tissues. In addition, it inhibited the activation of pathogenic T helper 1 (Th1) and Th17 cells in draining LNs. MDSCs increased the frequency of CD25 + Foxp3 + regulatory T cells and the mRNA expression of IL-10, as an immune modulator. Conclusions MDSCs suppressed inflammation and oxidative stress in the retina and inhibited pathogenic T cells in the LNs in EAU. Therefore, ocular administration of MDSCs has therapeutic potential for uveitis.

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Section: Methodsmentioning

confidence: 49%

Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation

Lee,

Kim,

Sohn

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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“…A study of these biomarkers can help with targeted therapy in pterygium patients and prevent recurrence. [ 20 21 ]…”

Section: Discussionmentioning

confidence: 99%

Study of biomarkers p53, Ki-67, Bcl-2, and VEGF in pterygium

Ghosh,

Arora,

Hariani

et al. 2024

Indian Journal of Ophthalmology

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Purpose: To study the biomarkers present in primary pterygium samples of patients of Indian ethnicity and compare it with the samples obtained from the unaffected conjunctiva of the same eye. Methods: A prospective case-control study of 17 eyes in patients above 10 years of age with primary pterygium who underwent pterygium excision using limbal conjunctival autograft technique. The pterygium samples (cases) and conjunctival samples (controls) were sent for immunohistochemical (IHC) staining for the following biomarkers: p53, Bcl-2, Ki-67, and vascular endothelial growth factor (VEGF). Result: The immunohistochemistry of the samples and the controls revealed p53 positivity in 47.05% of pterygium samples and 29.4% of controls (P < 0.587). Nine cases each in pterygium and control samples were positive for Ki-67 expression. Differences in the staining pattern between the two groups were not statistically significant (P < 1.000). Bcl-2 positivity was seen in 10 pterygium samples (58.8%) and 12 controls (70.5%), with no statistical difference between the two groups (P < 0.455). VEGF expression was seen in both epithelial and endothelial cells of the samples and controls, with no statistical difference between the two groups, with P = 1.000 for the epithelial staining and P = 0.637 for endothelial staining. Conclusion: The expression of biomarkers was comparable in both groups. We conclude that pterygium, against common belief, might not be a localized disease process but a global ocular phenomenon where the apparently healthy tissue also has some ongoing disease process at a molecular level.

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“…The risk factors for this disease include age [ 65 ], male gender [ 66 ], and exposure to ultraviolet radiation [ 67 ]. Surgical intervention, chemotherapy agents (Thiothepa), and alkylating drugs (Mitomycin C) are among the available treatments [ 68 , 69 ]. Natural compounds, including curcumin, are also being investigated for this purpose and should be explored through more robust studies [ 70 ].…”

Section: Therapeutic Uses In Eye Diseasesmentioning

confidence: 99%

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Boroughani,

Tahmasbi,

Heidari

et al. 2024

Heliyon

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Pharmacological treatment strategies of pterygium: Drugs, biologics, and novel natural products

Cited by 9 publications

References 95 publications

Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation

Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation

Study of biomarkers p53, Ki-67, Bcl-2, and VEGF in pterygium

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

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