Pharmacological treatment for Kleine-Levin Syndrome

Oliveira, Márcio Moysés de; Conti, Cristiane Fiquene; Saconato, Humberto; Prado, Gilmar Fernandes do

doi:10.1002/14651858.cd006685.pub2

Cited by 20 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…İştah ve uykuyu azaltma gibi etkileri nedeni ile belirtileri kontrol etmede psikostimulanlar kullanılmıştır. 9 Modafinil ile belirti şiddetinde azalma ve MPH ile klinik iyileşme bildirilmiştir. 5,10 Psikostimulanların belirti ataklarının süresini azalttığı, ancak yineleme oranlarını değiştirmediği; literatürde atak sıklığını azaltan ajanlar konusunda bir görüş birliği olmasa da, genel olarak duygudurum düzenleyici etkileri olan antiepileptiklerin ve özellikle CBZ'nin atak şiddeti ile sıklığını azalttık-ları bilgisi ağırlık kazanmaktadır.…”

Section: Discussionunclassified

See 1 more Smart Citation

Diagnostic and treatment process in a 12-year old adolescent with Kleine-Levin syndrome: a case presentation

Erkuran¹,

Aydın²,

Sapmaz³

2017

Anadolu Psikiyatri Derg

View full text Add to dashboard Cite

show abstract

Section: Discussionunclassified

“…Duygudurum düzenleme etkisi de bulunan antiepileptik ilaçlardan KLS tedavisinde etkin olduğu bildirilen valproik asit, lamotrijin, gabapentin ve CBZ'dir. 9 Bildirilen olguda da CBZ ile atak süresinde kısalma, ataklar arası dönemde uzama ve bunlara ikincil işlevselliğin artması ile belirgin klinik düzelme sağlanmıştı.…”

Section: Discussionunclassified

Diagnostic and treatment process in a 12-year old adolescent with Kleine-Levin syndrome: a case presentation

Erkuran¹,

Aydın²,

Sapmaz³

2017

Anadolu Psikiyatri Derg

View full text Add to dashboard Cite

show abstract

“…In one patient, a recurrence was observed upon progressive lithium weaning, and a good response was obtained after lithium increase, as previously reported. 2,11,13,14,17,18 In two patients, however, unfavorable courses were observed: their episodes became progressively more frequent and longer, resulting in shorter illness-free intervals. This evolution seems to be more frequent than previously described, also in the light of a recent O Habra, R Heinzer, J Haba-Rubio et al Kleine-Levin Syndrome in Switzerland study on a large KLS cohort, 8 and challenges the idea of KLS representing a "benign" disease.…”

Section: 8-11mentioning

confidence: 99%

“…2,12 To date, no placebo-controlled trials concerning treatment management are available, although lithium seems to be the most efficacious prophylactic drug for patients with frequent and disabling episodes. 2,11,13,14 The prevalence of KLS, classically estimated at 1 per million, has been recently evaluated at 1.8 cases per million in France. 8 At our center, we currently follow several KLS patients, which led us to suspect a higher prevalence than described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Mimics of Kleine-Levin Syndrome: A Survey in French-Speaking Switzerland

Habra

Heinzer

Haba‐Rubio

et al. 2016

Journal of Clinical Sleep Medicine

View full text Add to dashboard Cite

Study Objective: Kleine-Levin syndrome (KLS) is a rare disease of unknown etiology, the diagnosis of which can be challenging. We aimed to estimate KLS prevalence in French-speaking Switzerland, and assess differences with mimicking conditions. Methods: In this cross-sectional study, KLS patients were identified through a population-based approach, including at our hospital and contacting all sleepcertified facilities and neurologists in French-speaking Switzerland. Furthermore, we identified patients referred to our center for suspected KLS that received other diagnoses. Relevant clinical data of these two groups was compared. Results: We identified 7 patients with diagnosed KLS (6 since 2009), leading to a prevalence estimation of 3.19 per million (95% confidence interval: 1.55-6.59). Median age at diagnosis was 17 years (range: 12-19), 71.4% of them were men, and mean diagnosis delay after the first episode was 20.1 ± 10.9 months. We identified 9 mimic patients referred to our center; they differed from KLS patients by their higher age at disease onset (median: 15 [range: 12-16] vs. 19 [range: 16-64] years; p < 0.001), suspected KLS as referral reason (more frequent in mimics, p = 0.003), and the presence of precipitating factors (more frequent in KLS, p = 0.011). Among the mimic patients, 77% (versus 28% in KLS) had a psychiatric diagnosis. Conclusions: This study suggests a relatively higher KLS prevalence than previously reported. As compared to KLS, mimic patients have higher age at symptom onset, are more often initially referred for KLS suspicion, and have a higher prevalence of psychiatric disorders.

show abstract

“…A systematic review suggests that based on case reports, stimulant drugs may improve sleepiness (but not other symptoms) and lithium significantly reduces duration of episodes and decreases relapses, with anticonvulsants having less robust data as preventive medications. 10 Although uncommon, KLS can have significant morbidity and should be recognized within the framework of core symptoms including hypersomnia, slowed cognition, apathy, and derealization. This case exemplifies the difficulties in the diagnosis and management of a syndrome that went underrecognized until appropriate treatment was instituted.…”

Section: -3mentioning

confidence: 99%

Clinical Reasoning: A 14-year-boy with spells of somnolence and cognitive changes

Gusmão

Maski

Urion³

2014

Neurology

View full text Add to dashboard Cite

A 14-year-old boy presented for admission after repeated episodes of lethargy and cognitive changes. He had a history of childhood absence epilepsy that had resolved with antiepileptics discontinued 1 year prior to presentation.Two months prior to admission, the patient had a febrile illness with headache and diarrhea that lasted a few days. It was attributed to a nonspecific viral infection, and he recovered quickly. Over the ensuing days, however, he developed increasing sleepiness, cognitive slowing with difficulty concentrating, and an illdefined abnormal perception. He stated feeling that "things were not right, it is as if I am not here." His parents reported changes in appetite that included hypophagia alternating with hyperphagia, as well as repeated purposeless behaviors such as tapping his fingers and verbal perseveration. His speech was described as "baby talk," as if he had regressed. This progressed to hypersomnolence, sleeping more than 15 hours/day.

show abstract

Pharmacological treatment for Kleine-Levin Syndrome

Abstract: Therapeutic trials of pharmacological treatment for Kleine-Levin Syndrome, with a double-blind, placebo-controlled design are needed.

Cited by 20 publications

References 30 publications

Diagnostic and treatment process in a 12-year old adolescent with Kleine-Levin syndrome: a case presentation

Diagnostic and treatment process in a 12-year old adolescent with Kleine-Levin syndrome: a case presentation

Prevalence and Mimics of Kleine-Levin Syndrome: A Survey in French-Speaking Switzerland

Clinical Reasoning: A 14-year-boy with spells of somnolence and cognitive changes

Contact Info

Product

Resources

About