Pharmacological Targeting of the Epidermal Barrier

Kemény, Lajos; Nagy, Nikoletta; Csoma, Zsanett; Szabó, Kornélia; Erős, Gábor

doi:10.2174/1381612822666160726094947

Cited by 6 publications

(8 citation statements)

References 98 publications

(160 reference statements)

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“…It is evident that the addition of cefaclor in the C. oestroides ointment completely inhibited the healing properties of the applied preparation, suggesting that the combination with at least certain antibiotic agents is not appropriate for the treatment of DFUs. Although systemic use of antibiotics is prescribed in patients with infected DFUs, the local application of specific antibiotic agents in infected DFUs may delay the therapeutic effect of certain healing agents …”

Section: Discussionmentioning

confidence: 99%

“…Although systemic use of antibiotics is prescribed in patients with infected DFUs, the local application of specific antibiotic agents in infected DFUs may delay the therapeutic effect of certain healing agents. [30][31][32][33][34] Undoubtedly, diabetic foot ulceration is a major health problem causing substantial social, medical, and economic burdens, thus requiring increasing awareness and more efficient management. Treatment of DFUs remains challenging as standard and alternative therapeutic interventions pose important limitations and disadvantages.…”

Section: Discussionmentioning

confidence: 99%

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Ointments containing Ceratothoa oestroides extract: Evaluation of their healing potential in the treatment of diabetic foot ulcers

Meimeti

Tentolouris

Manes

et al. 2019

Wound Repair Regeneration

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Diabetic foot ulceration is a common and severe complication of diabetes, causing substantial social, medical, and economic burdens. Treatment of foot ulcers remains challenging, thus requiring increasing awareness and more efficient management. This study investigates the efficacy of ointments, containing as main active ingredient the olive oil extract of the marine isopod Ceratothoa oestroides, in the treatment of patients with diabetic foot ulcers. Fifty‐two patients were allocated into four treatment groups either receiving therapy with an ointment containing extract of C. oestroides or extract of C. oestroides and eosin or extract of C. oestroides and cefaclor or no treatment. Patients were monitored for a period of 135 days by evaluation of transepidermal water loss, skin hydration, planimetry, photo‐documentation, and clinical condition. Treatment with the extract of C. oestroides demonstrated significant healing properties that became evident after 45 days of treatment and resulted in complete ulcer healing in 61% of the patients. A significant improvement in transepidermal water loss (p < 0.001), skin hydration levels (p < 0.001), and wound area (p < 0.001) was observed in all patients. Similar efficacy was demonstrated for the combination of C. oestroides extract with eosin treatment (p < 0.001). On the contrary, the combination of C. oestroides extract with cefaclor antibiotic agent completely inhibited the healing properties of the isopod extract and did not improve water loss, skin hydration, or wound area. An important factor for C. oestroides extract healing properties is its selective activity against Gram negative bacteria. Ointments containing C. oestroides extract alone or combined with the antimicrobial agent eosin emerges as an effective regimen for the treatment of diabetic foot ulcers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ointments containing Ceratothoa oestroides extract: Evaluation of their healing potential in the treatment of diabetic foot ulcers

Meimeti

Tentolouris

Manes

et al. 2019

Wound Repair Regeneration

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“…Based on several further studies, three potential theories can explain the negative effects of psychological stress on host defence function 17 , namely psychoneuroimmunoendocrine dysfunction, elevated plasma endogenous glucocorticoid levels, and the skin steroidogenic system.…”

Section: Literature Reviewmentioning

confidence: 99%

Relationship of Stress to Recurrence of Atopic Dermatitis in Adults

Achmad

Cahyawari

2022

J. Drug Delivery Ther.

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Atopic Dermatitis is a chronic disease common in children but can also reoccur in adults. Atopic dermatitis cases in Indonesia is five of the most common skin disease. Atopic Dermatitis is mainly caused by genetic factors and specific environments, including neurological and immunological factors. Of the many factors associated with atopic dermatitis, psychological stress can cause a recurrence of atopic dermatitis in adults and could cause an increase in the severity of atopic dermatitis symptoms. This research aims to find out if stress is related to the recurrence of atopic dermatitis in adults. This research is a correlation study done in February 2017 with 53 respondents that have passed the restriction criteria made by the researcher. The results from the statistical test show that p=0.003 (p<0,05) and r=0,398, which means that there is a significant correlation between stress and the recurrence of atopic dermatitis in adults, with low correlation strength.Keywords: Stress, Atopic Dermatitis

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“…One of the most important properties of our skin is the complex barrier it provides to separate the internal part of our body from the environment, limiting contact with harmful chemicals, microbes, allergens and radiation 1 – 3 . The major building blocks of the skin barrier are the keratinocytes, which are capable of recognizing the ever-changing environmental conditions and mounting appropriate responses to maintain the integrity of the human body 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Cutibacterium acnes regulates the epidermal barrier properties of HPV-KER human immortalized keratinocyte cultures

Bolla

Erdei

Urbán

et al. 2020

Sci Rep

Self Cite

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our skin provides a physical barrier to separate the internal part of our body from the environment. Maintenance of complex barrier functions is achieved through anatomical structures in the skin, the stratified squamous epithelium specialized junctional organelles, called tight junctions (TJs). Several members of our microbial communities are known to affect the differentiation state and function of the colonized organ. Whether and how interactions between skin cells and cutaneous microbes, including Cutibacterium acnes (C. acnes), modify the structure and/or function of our skin is currently only partly understood. Thus, in our studies, we investigated whether C. acnes may affect the epidermal barrier using in vitro model systems. Real-time cellular analysis showed that depending on the keratinocyte differentiation state, the applied C. acnes strains and their dose, the measured impedance values change, together with the expression of selected TJ proteins. These may reflect barrier alterations, which can be partially restored upon antibiotic-antimycotic treatment. Our findings suggest that C. acnes can actively modify the barrier properties of cultured keratinocytes, possibly through alteration of tight cell-to-cell contacts. Similar events may play important roles in our skin, in the maintenance of cutaneous homeostasis. One of the most important properties of our skin is the complex barrier it provides to separate the internal part of our body from the environment, limiting contact with harmful chemicals, microbes, allergens and radiation 1-3. The major building blocks of the skin barrier are the keratinocytes, which are capable of recognizing the everchanging environmental conditions and mounting appropriate responses to maintain the integrity of the human body 4,5. Maintenance of complex barrier functions is achieved through anatomical structures in the skin. The stratified squamous epithelium is the uppermost skin layer that contains live keratinocytes and contains specialized junctional organelles, called tight junctions (TJs), which are localized between the cells of the second and third layer of the stratum granulosum 6. TJs provide intimate links between adjacent cells and play major roles in establishing the epidermal barrier, as well as act as important determinants of transepidermal transport 7-9. The complex, multi-protein structure of TJs includes more than 40 proteins 10,11. Claudin (CLDN) protein family members are some of the most important TJ components, as they are critical for the regulation of barrier functions, including permselectivity, which determines the size, ionic charge and electric resistance of molecules that may be transported through the barrier 12,13. Keratinocytes are also in constant contact with various members of the cutaneous microbiota. One of the most well-known members of this community is the Cutibacterium acnes (C. acnes) bacterium, which, beginning with puberty, is a dominant species and preferentially inhabits sebum-rich skin regions 14,15. Current research is eluci...

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Pharmacological Targeting of the Epidermal Barrier

Cited by 6 publications

References 98 publications

Ointments containing Ceratothoa oestroides extract: Evaluation of their healing potential in the treatment of diabetic foot ulcers

Ointments containing Ceratothoa oestroides extract: Evaluation of their healing potential in the treatment of diabetic foot ulcers

Relationship of Stress to Recurrence of Atopic Dermatitis in Adults

Cutibacterium acnes regulates the epidermal barrier properties of HPV-KER human immortalized keratinocyte cultures

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