Pharmacological study on sympathetic inhibition of the urinary bladder in dogs.

Ohtsuka, Minoru; Mori, Jo; Tsujioka, Keiji; Kumada, Shigenobu

doi:10.1254/jjp.30.187

Cited by 12 publications

(4 citation statements)

References 9 publications

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“…With regard to the sympathetic nerve innervation of the rat bladder, an excitatory a-receptor (2) and an inhibitory 19-receptor (2, 4) have been reported on the detrusor muscle, and it has also been reported that reserpine induces hyperreflexia (5). In cat and dog bladder (16,17), sympathetic inhibition is mediated by an a-receptor in the pelvic ganglia and by a a-receptor on the detrusor muscle. In the present study, phentolamine (5 mg/kg, i.v.)…”

Section: Discussionmentioning

confidence: 99%

In vivo effects of drugs that act on the autonomic nervous system on the rat urinary bladder contraction accompanying micturition.

et al. 1987

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Abstract-We prepared an experimental system to study the effects of drugs on urinary bladder contraction and micturition simultaneously in rats anesthetized with urethane (1 g/kg, s.c.) and a-chloralose (25 mg/kg, s.c.). When Tyrode's solution was infused at a constant rate (0.8-1 ml/10 min) through a needle inserted into the bladder from the left ureter, the bladder pressure gradually and then steeply rose, and micturition took place.These changes in bladder pressure and micturition were constantly repeated. In this model, drugs which partially inhibited the bladder contractile force, e.g., atropine (0.01-1 mg/kg, i.v.) and hexamethonium (C6, 5 mg/kg, i.v.) increased the frequency of bladder contraction instead of decreasing the amount of solution excreted from the penis by bladder contraction. The rate of afferent discharges during bladder filling was increased after injection of atropine or C6, and this increase was considered to be responsible for the in duction of the increase in the frequency of bladder contraction.Drugs which inhibited the bladder contraction and interrupted micturition, e.g., C6 (20 mg/kg, i.v.) raised the bladder pressure until the solution leaked from the penis.As phentolamine (5 mg/kg, i.v.) or propranolol (1 mg/kg, i.v.) did not facilitate bladder motility but rather inhibited it, the inhibitory action of sympathetic nerves on bladder motility was considered to be weak in rats. This model was useful for studying the effect of drugs on bladder motility and micturition reflex.

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Section: Discussionmentioning

confidence: 99%

In vivo effects of drugs that act on the autonomic nervous system on the rat urinary bladder contraction accompanying micturition.

et al. 1987

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“…Electrical stimulation of sympathetic nerves (either the hypogastric nerve or the lumbar sympathetic chain) inhibits transmission in bladder ganglia of the cat (169,170,362,549) rabbit (649), guinea pig (3,423), and dog (489) but not in the rat (510, 606) or mouse (522). …”

Section: Peripheral Nervous Systemmentioning

confidence: 99%

Neural Control of the Lower Urinary Tract

Groat

Griffiths

Yoshimura

2014

Comprehensive Physiology

353

527

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This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

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“…Several species and experimental approaches have been used to investigate the physiology and pathophysiology of the urogenital tract. Most investigations have been performed under anaesthesia in rats [ 1], rabbits [ 2], cats [ 3, 4] or dogs [ 5, 16–18]. In conscious rabbits, vesical function [ 19] or AP have been explored [ 20] in separate experiments.…”

Section: Discussionmentioning

confidence: 99%

“…In cats, the micturition reflex [ 3] and bladder motility during filling [ 4] have also been studied in detail. In dogs, the sympathetic inhibitory mechanism of urinary bladder contraction induced by electrical stimulation of the pelvic nerve was studied [ 5].…”

Section: Introductionmentioning

confidence: 99%