Pharmacological Study ofCuscuta campestris Yuncker

Abstract

The dried ethanol extract of the whole plant of Cuscuta campestris Yuncker was studied for its analgesic, antipyretic, antiinflammatory as well as CNS‐depressant activities. The extract was given orally at doses of 50 and 100 mg/kg. A significant protection against the p‐benzoquinone‐induced writhing response in mice was observed. A marked lowering of the body temperature of both hyperthermic as well as normothermic mice was produced. Therefore, the extract possesses a hypothermic rather than an antipyretic effect. A marked inhibition of the carrageenan‐induced rat hind paw oedema was also obtained. Regarding its CNS action, the extract produced a decrease in the motor activity of mice placed on a rotarod. In the conditioned avoidance reaction test the percentage of failure to avoid electric shock was shown to be increased after administration of the extract without any effect on the escape behaviour of the trained rats. Therefore, the CNS‐depressant activity of the extract seems to be due to a tranquillizing effect. It could be concluded that the extract possesses analgesic, hypothermic, antiinflammatory as well as CNS‐depressant activities.

Phytochemical, Free Radical Scavenging and Antifungal Profile of Cuscuta campestrisYunck. Seeds

“…Compared to abovementioned species that are to large-scale investigated, C. campestris is still insufficiently studied. More precisely, one research study of C. campestris whole plant revealed its analgesic, anti-inflammatory and CNS-depressant activities [10]. Recent study of C. campestris whole plant extracts confirmed the presence of isorhamnetin, kaempferol, and quercetin and their linkage with antioxidant and anticancer activity [11].…”

The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial

“…is the most widespread species in the genus Cuscuta in the world (Holm et al, 1997). This plant has analgesic, hypothermic, anti-inflammatory, anti-proliferative effects and CNS depression activity (Agha et al, 1996). Cuscuta seed extract contains a variety of flavonoids, polysaccharides, alkaloids and other chemicals.…”

Medicinal uses, pharmacology, and phytochemistry of Convolvulaceae plants with central nervous system efficacies: A systematic review

“…In the genus Cuscuta , the whole plants of Cuscuta arvensis (Koca et al, ), Cuscuta campestris (Agha et al, ; Ghule et al, ), and C. chinensis (Akbar et al, ); the seeds of C. chinensis (Liao et al, ); and the stems of C. reflexa (Pal et al, ) all show analgesic effects in different animal models. Koca et al () reported that the methanol extract of Cu.…”

“…In the genus Cuscuta, the whole plants of Cuscuta arvensis (Koca et al, 2011), Cuscuta campestris (Agha et al, 1996;Ghule et al, 2011), and C. chinensis (Akbar et al, 1985); the seeds of C. chinensis ; and the stems of C. reflexa (Pal et al, 2003) As the largest genus in Convolvulaceae, a total of 12 Ipomoea species were reported to possess analgesic effects. Among them, the different parts of I. pes-caprae, including aerial parts (da Silva Barth et al, 2017;de Souza et al, 2000;Vieira et al, 2013), leaves (Bragadeeswaran et al, 2010), and whole plants (Ji et al, 2008), all showed in vivo analgesic effects.…”