Pharmacological study of anti-inflammatory activity of aqueous extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker)

Iwamoto, Renan Donomae; Antunes, Edson; Borghi, Alexandre Augusto; Sawaya, Alexandra Christine Helena Frankland; Landucci, Elen C.T.

doi:10.1016/j.jep.2018.11.012

Cited by 21 publications

(11 citation statements)

References 28 publications

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“…Ethnopharmacological studies report that the species M. laevigata and M. glomerata are popularly named guaco despite being morphologically and chemically similar both possess differences in the concentration and composition of some chemical compounds. Pasqua et al (2019) reported that the M. glomerata presents a bigger amount of coumarin than the specie M. laevigata, on the other hand, Santos et al (2006) and Bolina et al (2009) Based on the results, it can be seen that there are several parts of guaco used for treatment, such as: leaves and stems with their expectorant, anti-inflammatory, anxiolytic, bronchodilator, appetite stimulant properties; flowers and roots with their property of tonic, depurative, antipyretic action; bark with its anti-influenza, anti-inflammatory, anti-neuralgic, anti-rheumatic, antiseptic, bekic, depurative, diuretic and emollient property; plant with its antimicrobial, anti-inflammatory, analgesic, spasmodic, vasodilator, anti-ulcer, central nervous system depressant and anti-venom property . In the studied extracts of M. glomerata, one of the main classes of secondary metabolites is coumarin, which is richly used to treat symptoms such as cough, expectoration, and dyspnea.…”

Section: Discussionmentioning

confidence: 99%

“…ex Baker). Both vegetable species share chemical characteristics and morphological similarities, as the uses and therapeutical indications, being the phytotherapic medicine most consumed for the treatment of asthmatic bronchitis, cough, and hoarseness (Costa, Borghi, Mayer, & Sawaya, 2018;Coutinho, Gonçalves, & Marcucci, 2020;Della Pasqua et al, 2019;E Silva et al, 2012;João C. Gasparetto, Campos, Budel, & Pontarolo, 2010;Moreti et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…For quality control, the Brazilian Pharmacopeia recommends the use of High-Performance Liquid Chromatography (HPLC) for quantification of coumarins in the extracts of leaves from both vegetable species. Beyond coumarin are reported other chemical substances as derivatives of coumaric acid, lupeol, dihydrocoumarin, caffeic, kaurenoic, and chlorogenic acids, among others, that can be used for chemical differentiation of the species (Bertol, Cobre, & Pontarolo, 2021;Della Pasqua et al, 2019;Ormond et al, 2022). Moreover, M. glomerata and M. laevigata are known for the same vulgar nomenclature, possessing the same uses, witch can be replaced of each other.…”

Section: Introductionmentioning

confidence: 99%

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The therapeutic properties of Mikania glomerata Spreng. (Asteraceae)

Santos¹,

Melo

Lima

et al. 2022

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The Mikania glomerata Spreng is a specie found in Europe, Africa, North and South America and is commonly known as “guaco” and “guaco climber”. Many scientific studies confirm the bactericidal, anti-ophidic, antifungal, anti-inflammatory, antimalarial, and bronchodilator pharmacological activities. These studies aim to contribute to new research, report the phytotherapy aspects and describe the therapeutical properties of Mikania glomerata. This study is an integrative review with a descriptive approach. Were found during the study that the guaco therapeutical properties are diverse, such as: antiasthmatic, tonic, antipyretic, expectorant, appetite stimulant, anti-influenza, antirheumatic, soothing, healing, diuretic, emollient, fluidizing, bacterial growth inhibitor, antiallergic, antifungal, antioxidant, anthelmintic. Thereby, the analyzed texts show, besides the properties mentioned above, an expressive performance on duodenal and stomach ulcers, infectious diseases such as tonsillitis and oropharyngeal inflammation, influenzas, and upper airway infections (UAI), usually known as cold. Thus, is essential to highlight the value of the medicinal use of this compound, in a way to accentuate their benefits for the clinical improvement of various conditions that currently affect patients. However, given the data that were shown previously, as well as the limited number of studies, it is fundamental to carry out more research to define more safely the therapeutic properties of the M. glomerata, in addition to showing the long-term effects of the use of your phytotherapic and safe doses, such as side effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The therapeutic properties of Mikania glomerata Spreng. (Asteraceae)

Santos¹,

Melo

Lima

et al. 2022

RSD

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“…F. chica, popularly known as 'pariri', is used as anti-inflammatory (LIMA et al 2020), healing and anti-anemic agent, and is also used to treat intestinal colic, hemorrhage, diarrhea and leukemia (BEHRENS et al, 2012). M. laevigata, commonly known as 'guaco', has leaves rich in coumarin and are used in the treatment of respiratory disorders, having anti-inflammatory action (DELLA PASQUA et al 2019). V. curassavica, known as 'erva-baleeira', has anti-inflammatory activity (OLIVEIRA et al, 2020a) and is used as raw material for the first herbal medicine fully developed in Brazil, Acheflan © , which is based on the essential oil from this species (LIMA et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Growth, leaf gas exchange and mycorrhizal colonization of three medicinal species submitted to different irradiance levels

et al. 2022

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This study o evaluated growth, leaf gas exchange and arbuscular mycorrhizal fungi root colonization in three medicinal plant species under different irradiance intensities. Fridericia chica (Bonpl.) L.G.Lohmann, Mikania laevigata Sch.Bip. ex Baker and Varronia curassavica Jacq. were propagated by cutting and cultivated for 120 days in artificially shaded environments using black shade-type screens, obtaining four irradiance levels: 100%, 70%, 50% and 30%. The experimental design was completely randomized in a 3 x 4 factorial scheme (three plant species and four irradiation levels) with seven replicates. The three medicinal species showed higher liquid assimilation, mass growth and arbuscular mycorrhizal fungi root colonization rates when exposed to environments with 70% light availability. In relation to physiological responses, V. curassavica presented higher photosynthetic rate, stomatal conductance and transpiration when submitted to 70% irradiance, being able to be cultivated in more open environments with higher irradiation levels. Conversely F. chica and M. laevigata presented shade tolerance characteristics. At the initial growth phase, the results obtained can be used as indicators to recommend the ideal cultivation environment for these species in agroforestry systems.

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“…Essas aplicações tendem a aprimorar e agilizar os processos de caracterização e diminuir as extenuantes etapas de fracionamento, isolamento e elucidação de metabólitos secundários presentes nos indivíduos. 10 Pode-se chamar de técnicas hifenadas o acoplamento entre duas ou mais técnicas de análise com o objetivo de obter uma ferramenta analítica mais rápida e eficiente que as técnicas isoladas. As técnicas analíticas mais utilizadas em produtos à base de plantas medicinais e outros de origem natural são a espectroscopia e a cromatografia.…”

Section: Introductionunclassified

Hifened Analytical Techniques in the Identification of Chemical Markers and Adulterations in Natural Products

2020

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The use of phytotherapic and herbal medicines has increased in recent years. Because of the growing demand, quality control for these drugs becomes increasingly necessary. The most widely practice used nowadays for standardization of products of plant origin is the identification of the phytochemical markers that, are characteristic for each species. However, such methodology can be inefficient, as many markers have no relationship with the biological activity of each plant. The simultaneous use of some already known analytical techniques not only can be an alternative to the quality control of these phytopharmaceuticals but also results in evaluation of these chemical compounds in its entirety. This work is a literature review, which evaluated different coupled analytical methods-which, reported better sensitivity, ease and accuracy in analysis-to highlight the most appropriate methodology to identify possible adulterations in herbal drugs and phytotherapics to ensure its efficacy, safety and quality to consumers. The data generated from these hyphenated analytical techniques and, the use of chemometrics, result in more valuable information regarding the authenticity of the plants used in the fabrication of herbal medicinal products. Modern analytical methods such as HPLC and UHPLC when used simultaneously with MS, RMN and chemometrics generate more precise and faithful results in the referred analysis and are useful tools in the identification of adulteration in herbal drugs and phytotherapics. A utilização de medicamentos fitoterápicos e drogas vegetais pela população e a busca por terapias à base de plantas tem crescido consideravelmente nos últimos anos. Com essa crescente demanda, torna-se cada vez mais necessário o controle de qualidade eficiente para esses medicamentos. A prática mais utilizada nos dias atuais para padronização de produtos de origem vegetal é a identificação de seus marcadores fitoquímicos, que são característicos para cada espécie. Porém, sabe-se que tal metodologia pode deixar a desejar, visto que muitos marcadores podem não apresentar relação com sua atividade biológica. Uma alternativa para o controle de qualidade mais eficiente desses produtos consiste na utilização de técnicas analíticas já conhecidas, o que resulta na avaliação desses fitoterápicos em sua totalidade. Este trabalho é uma revisão bibliográfica, em que foram avaliados diferentes métodos analíticos acoplados e pretende informar sobre as metodologias que tenham maior sensibilidade, facilidade e fidelidade nas análises, a fim de evidenciar quais seriam mais apropriadas na verificação de possíveis adulterações e fraudes em fitoterápicos e drogas vegetais, garantindo maior eficácia, segurança e qualidade para o consumidor. Os dados gerados a partir do uso de técnicas analíticas hifenadas e a utilização da quimiometria na interpretação dos dados, resultam em informações valiosas no que diz respeito à autenticidade das plantas utilizadas na produção dos medicamentos à base de drogas vegetais. Foi possível observar que o uso ...

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Pharmacological study of anti-inflammatory activity of aqueous extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker)

Cited by 21 publications

References 28 publications

The therapeutic properties of Mikania glomerata Spreng. (Asteraceae)

The therapeutic properties of Mikania glomerata Spreng. (Asteraceae)

Growth, leaf gas exchange and mycorrhizal colonization of three medicinal species submitted to different irradiance levels

Hifened Analytical Techniques in the Identification of Chemical Markers and Adulterations in Natural Products

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