Pharmacological Studies on Marbofloxacin on Diarrheic Calves

Abstract

One –hundred diarrheic calves were used to differentiate various reasons for calf diarrhea by using rapid diagnostic kits which found the main causative agents for diarrhea occurrence are corona virus (28%), Rota virus (25%), Cryptosporidium (24%) and E. coli (23%), Respectively, in addition to study concurrent use of marbofloxacin (a third generation member of quinolone) in treatment of diarrheic calves infected with E. coli. Then twenty Holstein calves (0-10 days old) in special dairy farm at Damietta Governorate were isolated and divided into two groups, each group contain ten animals. First group was kept as control without any drug. The second group include ten diarrheic calves infected with E-coli and was injected by marbofloxacin intramuscularly (2mg/kg B. W) for 3 successive days. Results revealed a significant increase in total leukocytic count, lymphocyte count, monocyte count, eosinophil count, globulin, ALT, AST, ALP, creatinine and urea level. On other hand results recorded a significant decrease in total erythrocytic count, hemoglobin content, PCV, MCH, MCHC, total protein, Albumin and thrombocyte count in marbofloxacin treated group compared to control one.