Pharmacological Studies on Laminine Monocitrate

Ozawa, Hikaru; Gomi, Yasuo; Otsuki, Isao

doi:10.1248/yakushi1947.87.8_935

Cited by 14 publications

(4 citation statements)

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“…contain a basic amino acid, a (5-amino-5-carboxypentyl)-trimethyl ammonium hydroxide, named laminine by Takemoto et al (1965), which shows a weak transitory action in depressing the blood pressure (Ozawa et al, 1967). contain a basic amino acid, a (5-amino-5-carboxypentyl)-trimethyl ammonium hydroxide, named laminine by Takemoto et al (1965), which shows a weak transitory action in depressing the blood pressure (Ozawa et al, 1967).…”

Section: C) Protein and Amino Acidsmentioning

confidence: 99%

The main seaweed foods in Japan

Nisizawa

Noda

Kikuchi³

et al. 1987

Hydrobiologia

227

100

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Section: C) Protein and Amino Acidsmentioning

confidence: 99%

The main seaweed foods in Japan

Nisizawa

Noda

Kikuchi³

et al. 1987

Hydrobiologia

227

100

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“…These results may be compared to those obtained by Ozawa (6) showing that high doses of laminine [103M] inhibited the contraction-inducing effect of spasmogenic agonists on isolated preparations of smooth and striated muscle and potentiated the effect of noradrenaline on the vas deferens.…”

Section: Hypotensive Action At High Dosesmentioning

confidence: 74%

“…We report here our results on laminine, a basic amino acid isolated for the first time from Laminaria angustata (5) and presented as having a low hypotensive activity (6). It should be pointed out that brown algae of the Laminariaceae family have been used for centuries as a hypotensive drug in oriental medicine (1,2,7).…”

Section: Introductionmentioning

confidence: 94%

Hypotensive Constituents of Marine Algae; 1. Pharmacological Studies of Laminine

Girard¹,

Marion²,

Liutkus³

et al. 1988

Planta Med

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The effect on blood pressure of laminine (5-amino-S-carboxypentyltrimethylammonium hydroxide), which is widely distributed in brown algae of the Laminariaceae family, was studied to see if it contributes to the hypotensive activity of these algae which have been used for centuries in oriental medicine. The results show that this compound, at high doses, does have a hypotensive action as a result of a ganglion-blocking effect. As laminine is only present in low concentrations in these algae, its ganglion-blocking activity is not responsible for their hypotensive effect.

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“…Takemoto and his co-workers isolated the hypotensive component according to the classic isolation scheme similar to the one mentioned earlier (Scheme 5) (16). The active component, laminine, proved to be the (5-amino-5-carboxypentyl)-trimethylam- monium salt and is shown to have transitory action that depresses the blood pressure of rabbits and lowers the contraction of smooth muscles (17). Since then, laminine has been found widely distributed and is probably responsible for hypotensive activity found in various algae (18).…”

Section: Preparationmentioning

confidence: 97%