Pharmacological studies of some new antitumor compounds (review)

Syrkin, A. B.; Konyaeva, O. I.

doi:10.1007/bf00773010

Cited by 2 publications

(2 citation statements)

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“…For example, Chanerol is a complex polyphenolic medicinal drug prepared from the blossoms of fireweed (Pukhal'skaia et al, 1970;Petrova et al, 1974;Pukhalskaya et al, 1975). It is likely that oenothein B is one of main bioactive constituents of Chanerol and could be responsible for its pharmacological activities (Spiridonov et al, 1997;Sasov et al, 2010), including antitumor activity (Syrkin and Konyaeva, 1984). An aqueous extract of E. angustifolium was patented for use as an oral antiinflammatory treatment (German Patent No.…”

Section: Clinical Studiesmentioning

confidence: 99%

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

Schepetkin

Ramstead

Kirpotina

et al. 2016

Phytotherapy Research

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Epilobium angustifolium is a medicinal plant used around the world in traditional medicine for the treatment of many disorders and ailments. Experimental studies have demonstrated that Epilobium extracts possess a broad range of pharmacological and therapeutic effects, including antioxidant, anti-proliferative, anti-inflammatory, antibacterial, and anti-aging properties. Flavonoids and ellagitannins, such as oenothein B, are among the compounds considered to be the primary biologically active components in Epilobium extracts. In this review, we focus on the biological properties and the potential clinical usefulness of oenothein B, flavonoids, and other polyphenols derived from E. angustifolium. Understanding the biochemical properties and therapeutic effects of polyphenols present in E. angustifolium extracts will benefit further development of therapeutic treatments from this plant.

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Section: Clinical Studiesmentioning

confidence: 99%

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

Schepetkin

Ramstead

Kirpotina

et al. 2016

Phytotherapy Research

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“…Res. 19, 428-432 (2005) angustfolium (Pukhalskaya et al, 1975;Syrkin and Konyaeva, 1984), Rhodiola rosea (Dementyeva and Yaryomenko, 1987) and Bergenia crassifolia (Amosova et al, 1994). A number of species that are traditionally employed in anticancer phytocompositions did not demonstrate significant cytotoxic activity against lymphoblastoid cells in our experiments.…”

Section: Cytotoxicity Of Crude Plant Extractsmentioning

confidence: 99%

Cytotoxicity of some Russian ethnomedicinal plants and plant compounds

2005

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The cytotoxic action of crude ethanol extracts from 61 plant species used in Russian ethnomedicine for alleviating symptoms of diseases in cancer patients was studied on cultured human lymphoblastoid Raji cells. Extracts from Chelidonium majus, Potentilla erecta, Chamaenerium angustfolium, Filipendula ulmaria and Inula helenium possessed marked cytotoxicity, suppressing the growth of the cells at concentrations of 10 and 50 microg/mL. The cytotoxicity of purified active compounds from selected plant species was evaluated along with pharmaceutical antineoplastic drugs methotrexate, fluorouracil, cyclophosphamide and vinblastine. Sesquiterpene lactones helenin, telekin and artemisinin, aromatic polyacetylene capillin, and alkaloid preparation sanguirythrine suppressed cell growth at concentrations of 1-2 microg/mL, which exceeds the cytotoxicity of cyclophosphamide and fluorouracil.

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Pharmacological studies of some new antitumor compounds (review)

Cited by 2 publications

References 1 publication

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed)

Cytotoxicity of some Russian ethnomedicinal plants and plant compounds

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