Pharmacological studies of ketoprofen (19583RP) III. Anti-inflammatory, analgesic and antipyretic actions in subcutaneous administration.

A simple two-step process for the preparation of ketoprofen sodium was developed. The procedure involved dissolution of ketoprofen in ethanolic NaOH followed by evaporation of the solvent. The resulting amorphous solid was crystallized by controlled precipitation from 96% ethanol. The sodium salt proved to be stable for 4 years and its aqueous solutions for at least 1 year (investigated period). Ketoprofen sodium appears to be an alternative bulk form to ketoprofen acid for production of formulations after further characterization of the compound.

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Long-term Continuous Subcutaneous Infusion of Ketoprofen Combined With Morphine: A Safe and Effective Approach to Cancer Pain

Moselli

Cruto

Massucco³

et al. 2010

The Clinical Journal of Pain

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Pharmacological studies of ketoprofen (19583RP) III. Anti-inflammatory, analgesic and antipyretic actions in subcutaneous administration.

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Changes in body temperature after administration of antipyretics, LSD, Δ9-THC, CNS depressants and stimulants, hormones, inorganic ions, gases, 2,4-DNP and miscellaneous agents

Changes in body temperature after administration of antipyretics, LSD, Δ9-THC, CNS depressants and stimulants, hormones, inorganic ions, gases, 2,4-DNP and miscellaneous agents

Ketoprofen Sodium: Preparation and Its Formation of Mixed Crystals with Ketoprofen

Long-term Continuous Subcutaneous Infusion of Ketoprofen Combined With Morphine: A Safe and Effective Approach to Cancer Pain

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