Pharmacological studies of Crinum, Ammocharis, Amaryllis and Cyrtanthus species of the South African Amaryllidaceae

Nair, Jerald J.; Staden, J. Van

doi:10.1016/j.sajb.2021.12.021

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…This neurotransmitter is found in the brain and at neuromuscular junctions, and acetylcholine hydrolysis is essential for synaptic cholinergic transmissions before new electrical impulses (Sobiecki, 2002). This process is carried out by the enzyme AChE, which mediates synapses in the nervous system (Nair and Van Staden, 2022). Inhibition of acetylcholinesterase activity is one of the most notable effects of alkaloids from a wide range of different species of Amaryllidaceae (Maroyi, 2016).…”

Section: Pharmacologymentioning

confidence: 99%

Pharmacological and toxicological effects of Amaryllidaceae

Paiva,

Nascimento,

Damasceno

et al. 2023

Braz. J. Biol.

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The Amaryllidaceae family is widely distributed in the tropics, presenting biological activity attributed mostly to alkaloids, such as an important inhibitory activity of acetylcholinesterase (AChE), antifungal, antibacterial, and cytotoxic activities. The present study aims to review the spectrum of action of the main biological activities and toxicity of secondary metabolites found in Amaryllidaceae through a literature review, using Prisma and the descriptors “Pharmacological effects of Amaryllidaceae” and “Amaryllidaceae family” and “Pharmacological actions of Amaryllidaceae”, used in English and Portuguese. The literature search was done in March and May 2023. Original works published from 2012 to 2023, available in full, and presenting experimental and clinical studies were included. After the selection considering the inclusion and exclusion criteria, 60 articles fulfilled the defined criteria. From a pharmacological point of view, the highlight is due to the alkaloid galantamine, which has the potential- and is already used - for treating Alzheimer's. The toxicological aspect must be considered and evaluated carefully, as alkaloids have been associated with adverse effects such as nausea, vomiting, diarrhea, abdominal pain, and cardiovascular, neurological, and respiratory changes. Furthermore, some studies indicate that consuming these plants in significant quantities can lead to hepatic and renal toxicity. Therefore, the therapeutical use of this family's plant drugs and derivatives requires further studies to elucidate its effects and point out metabolites with therapeutic potential.

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Section: Pharmacologymentioning

confidence: 99%

Pharmacological and toxicological effects of Amaryllidaceae

Paiva,

Nascimento,

Damasceno

et al. 2023

Braz. J. Biol.

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“…The utilization of natural compounds from plants has garnered attention as it offers an innovative and less toxic approach to combating cancer, minimizing the side effects associated with conventional treatments [5]. However, despite their therapeutic potential, challenges remain, such as determining the effective dose, assessing toxicity, and understanding the bioavailability of these compounds [6,7].…”

Section: Introductionmentioning

confidence: 99%

Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines: A literature review

Martins de Paiva,

do Nascimento,

de Melo Damasceno

et al. 2024

ELECTRON J GEN MED

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Amaryllidaceae alkaloids have attracted significant attention in cancer research for their potential antitumor properties. To date, numerous studies have investigated the effects of these alkaloids on cancer cell lines, but a comprehensive synthesis of the existing evidence through a literature review is warranted. This article presents a comprehensive literature review aimed at evaluating the antitumor effects of amaryllidaceae alkaloids on various cancer cell lines and elucidating the underlying mechanisms of action. A search was conducted in major scientific databases, including Google Scholar, PubMed, Scopus, and Web of Science, to identify relevant studies published between 2013 and 2023. Studies that examined the antitumor effects of amaryllidaceae alkaloids on cancer cell lines were included in the review. Data were extracted, analyzed, and synthesized to provide an in-depth overview of the findings. The alkaloids exhibited potent cytotoxicity and suppressed cell proliferation in a concentration-dependent manner. Mechanistic investigations unveiled that amaryllidaceae alkaloids induced apoptosis, cell cycle arrest, and hindered angiogenesis in cancer cells. Moreover, they demonstrated favorable selectivity towards cancer cells, sparing normal cells, suggesting potential as targeted therapies. This literature review consolidates and critically appraises the available evidence on the antitumor effects of amaryllidaceae alkaloids on cancer cell lines. The findings underscore their potential as promising candidates for further exploration in cancer therapeutics. Future preclinical and clinical studies are vital to advance their development and translation into effective anticancer drugs.

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“…Considering the number of scientific articles describing the different aspects of AA, several articles were published on this topic regarding the phytochemical, biological and pharmacological properties of Crinum bulbispermum [ 13 ] Nerine [ 14 ], Haemantheae [ 15 ] and Crinum , Ammocharis , Amaryllis and Cyrtanthus [ 16 ]. The relation between the biological activity of AA and their absolute configuration was also extensively described [ 17 ] as well as the acetylcholinesterase inhibition of extracts of Amaryllidaceae collected in South Africa with potential for Alzheimer’s disease treatment [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Advances on the Amaryllidacea Alkaloids Collected in South Africa, Andean South America and the Mediterranean Basin

Evidente

2023

Molecules

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The alkaloids are one of the most represented family of natural occurring biological active compounds. Amaryllidaceae are also very well known for their beautiful flower and are thus used as ornamental plants in historic and public gardens. The Amaryllidacea alkaloids constitute an important group that is subdivided into different subfamilies with different carbon skeletons. They are well known from ancient times for their long application in folk medicine, and in particular, Narcissus poeticus L. was known to Hippocrates of Cos (ca. B.C. 460–370), who treated uterine tumors with a formulate prepared from narcissus oil. To date, more than 600 alkaloids of 15 chemical groups exhibiting various biological activities have been isolated from the Amaryllidaceae plants. This plant genus is diffused in regions of Southern Africa, Andean South America and the Mediterranean basin. Thus, this review describes the chemical and biological activity of the alkaloids collected in these regions in the last two decades as weel those of isocarbostyls isolated from Amaryllidaceae in the same regions and same period.

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Pharmacological studies of Crinum, Ammocharis, Amaryllis and Cyrtanthus species of the South African Amaryllidaceae

Cited by 4 publications

References 35 publications

Pharmacological and toxicological effects of Amaryllidaceae

Pharmacological and toxicological effects of Amaryllidaceae

Antitumor evaluation of amaryllidaceae alkaloids on cancer cell lines: A literature review

Advances on the Amaryllidacea Alkaloids Collected in South Africa, Andean South America and the Mediterranean Basin

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