Pharmacological screening of traditional medicinal plants used to treat skin ailments in the Free State Province of South Africa

Xaba, Valeria Makhosazana; Buwa, L.V.

doi:10.1016/j.sajb.2016.02.192

Cited by 4 publications

(9 citation statements)

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“…The roots of P. prunelloides are mixed with those of Dicoma anomala Sond. [24][25][26]30,31] or are mixed with roots of D. anomala and bulbs of Hypoxis colchicifolia Baker [24,25,27] as remedy for insect and sting bites. According to Masika and Afolayan [32], the leaves of P. prunelloides are mixed with those of Cannabis sativa L. and glycerin as ethnoveterinary medicine for conjunctivitis and retained placenta.…”

Section: Medicinal Uses Of P Prunelloidesmentioning

confidence: 99%

“…The concentrations of the trace elements in P. prunelloides roots were below the permissible limits set by Codex Alimentarius Commission [80] and, therefore, Mtunzi et al [79] concluded that the species extracts used as herbal medicines may not result in heavy metal toxicity. Phytochemical compounds that have been identified from the leaves and roots of P. prunelloides include alkaloids, anthocyanidins, anthraquinones, cardiac glycosides, flavonoids, glucose, saponins, steroids, sucrose, tannins, and terpenoids [6,31,44,62,[81][82][83][84]. Other phytochemical compounds that have been identified from the leaves and roots of P. prunelloides include alanine, allo-isoleucine, α-aminobutyric acid, arabinose, asparagine, aspartic acid, diosgenin, (-)-epicatechin, epicatechin gallate, epigallocatechin gallate, glucuronic acid, hexoses, kaempferol, oleanolic acid, palmitic acid, quercetin, rhamnose, serine, tormentic acid, and valine [6,42,44,47,62,82,84,85].…”

Section: Chemistry and Phytochemistry Of P Prunelloidesmentioning

confidence: 99%

“…The following biological activities have been reported from the leaf and root extracts of P. prunelloides: antibacterial [25,30,31,42,47,60,61,65,[86][87][88][89], antimycobacterial [8,61,90,91], antifungal [25,30,31,[87][88][89], antiviral [42], antidiabetic [84], anti-inflammatory [31,42,43,61,83,87,88,90,92], analgesic [83], antioxidant [6,31,43,62,84,87,87], uterotonic [2,92], and cytotoxicity [6,62] activities.…”

Section: Biological Activities Of P Prunelloidesmentioning

confidence: 99%

“…The extracts exhibited activities with MIC values ranging from 150.0 µg/ml to 650.0 μg/ml [87,88]. Xaba [31] and Xaba and Buwa [89] evaluated the antibacterial activities of methanol, ethanol, acetone, and aqueous root extracts of P. prunelloides against P. aeruginosa, Bacillus pumilus, S. aureus, E. coli, and K. pneumonia using microplate dilution assay. The extracts exhibited activities with MIC values ranging between 0.1 mg/ml and 6.3 mg/ml [31,89].…”

Section: Antibacterial Activitiesmentioning

confidence: 99%

“…Xaba [31] and Xaba and Buwa [89] evaluated the antifungal activities of methanol, ethanol, acetone, and aqueous root extracts of P. prunelloides against C. albicans and Trichophyton mucoides using microplate dilution assay. The extracts exhibited activities with an MIC value of 0.5 mg/ml [31,89].…”

Section: Antifungal Activitiesmentioning

confidence: 99%

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A Review of Botany, Medicinal Uses, and Biological Activities of Pentanisia Prunelloides (Rubiaceae)

Maroyi

2019

Asian J Pharm Clin Res

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This study is aimed at providing a critical review of the botany, biological activities and medicinal uses of P. prunelloides. Documented information on botany, biological activities, and medicinal uses of P. prunelloides was collected from several online sources which included BMC, Scopus, SciFinder, Google Scholar, Science Direct, Elsevier, PubMed, and Web of Science. Additional information on the botany, biological activities, and medicinal uses of P. prunelloides was gathered from book chapters, books, journal articles, theses, and scientific publications sourced from the University of Fort Hare Library. The study showed that the leaves and roots of P. prunelloides are used as herbal medicines for bodily pains, burns, cancer, diabetes, fever, gastrointestinal problems, heartburn, heart problems, respiratory problems, retained placenta, rheumatism, sexually transmitted infections, skin infections, snakebite, sores, wounds, toothache, and vomiting. Pharmacological research revealed that P. prunelloides extracts have antibacterial, antimycobacterial, antifungal, antiviral, antidiabetic, anti-inflammatory, analgesic, antioxidant, uterotonic and cytotoxicity activities. Future studies should focus on evaluating the phytochemical, pharmacological, and toxicological activities of P. prunelloides crude extracts as well as chemical compounds isolated from the species.

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Section: Medicinal Uses Of P Prunelloidesmentioning

confidence: 99%

Section: Chemistry and Phytochemistry Of P Prunelloidesmentioning

confidence: 99%

Section: Biological Activities Of P Prunelloidesmentioning

confidence: 99%

Section: Antibacterial Activitiesmentioning

confidence: 99%

Section: Antifungal Activitiesmentioning

confidence: 99%

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A Review of Botany, Medicinal Uses, and Biological Activities of Pentanisia Prunelloides (Rubiaceae)

Maroyi

2019

Asian J Pharm Clin Res

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Conservation of Medicinal Plant Genetic Resources in Southern Africa

Pillay

Takaidza

Madike

et al. 2022

Plant Genetic Resources, Inventory, Collection and Conservation

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Soxhlet extractor coupled with Liquid-liquid extraction: Setting up a pilot library of refined crude extracts from indigenous medicinal plants of Lesotho

Hlokoane¹,

Lekatsa²,

Jimi³

et al. 2020

J. Med. Plants Stud.

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Infections associated with multidrug resistant organisms result in increased morbidity and mortality in Lesotho and globally, thus, there is immediate need to discover new antibiotics against resistant bacteria through systematic examination of inexpensive local herbs. Here, we report for the first time, the welldefined and publicly available prototype library that consists of 20 different crude extracts derived from crude drug samples of medicinal plants of Lesotho used for treatment of infectious diseases. We also described the coupling of soxhlet extraction with liquid-liquid fractionation to give partially refined organic and aqueous extracts, and disclose that the extracts from the leaves and whole plant contained about twice as much organic soluble phytochemicals as aqueous soluble phytoconstituents. While the roots and bark contained about 2 and 5 times more of aqueous soluble than organic soluble phytochemicals respectively, especially when extracting with 90% ethanol. The library represents the potential phytochemicals in herbal prescriptions dispensed by traditional healers in Lesotho. The extracts are publicly available upon request through the corresponding author and efforts to expand the library are still continuing. This methodology could be followed to develop other libraries.

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Pharmacological screening of traditional medicinal plants used to treat skin ailments in the Free State Province of South Africa

Cited by 4 publications

References 0 publications

A Review of Botany, Medicinal Uses, and Biological Activities of Pentanisia Prunelloides (Rubiaceae)

A Review of Botany, Medicinal Uses, and Biological Activities of Pentanisia Prunelloides (Rubiaceae)

Conservation of Medicinal Plant Genetic Resources in Southern Africa

Soxhlet extractor coupled with Liquid-liquid extraction: Setting up a pilot library of refined crude extracts from indigenous medicinal plants of Lesotho

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