Pharmacological screening of some Brazilian plants

Barros, Glauce S. G.; Matos, F. J. A.; Vieira, J E; Sousa, M.P.; Medeiros, Mary C.

doi:10.1111/j.2042-7158.1970.tb08403.x

Cited by 41 publications

(17 citation statements)

References 13 publications

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“…These results indicated that the crude extract of Z. hyemale acted as a non-competitive antagonist of contractions induced by Ach and BaCl 2 . An antispasmodic activity (on rabbit duodenum) was also verified for the crude ethanolic and aqueous extract of Z. rhoifolium [3]. Compound 4 increased pD 2 of BaCl 2 -induced contraction and lupeol increased pD 2 of cumulative concentration-response curves of Ach.…”

Section: Resultsmentioning

confidence: 99%

“…It has been used in Brazilian folk medicine as a potent antithermic, antispasmodic, astringent, and tonic agent [2]. Previous studies on the crude extract of Z. rhoifolium (Rutaceae) reported the reduction of the activity of the intestinal smooth muscle [3]. As a continuation of our chemical studies on plants of the Rutaceae's family [4], [5], the analysis of the chemical constituents ( Fig.…”

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confidence: 98%

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Alkaloids, Amides and Antispasmodic Activity of Zanthoxylum hyemale

et al. 2002

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Two quinoline alkaloids, (-)-R-geilbalansine (1) and hyemaline (2), as well as aromatic amide, N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl)-2-methoxyethyl]benzamide (O-methylbalsamide) (3), were isolated as new natural products from the stem barks of Zanthoxylum hyemale, together with seven known compounds. Their structures were determined on the basis of spectroscopic data (IR, (1)H- and (13)C-NMR, MS). In addition, the antispasmodic activity of the crude extract of Z. hyemale and three other more abundant isolated compounds (4, 5 and 10) were studied in two different antispasmodic test models on isolated rat ileum and only the crude ethanolic extract presented antispasmodic activity.

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Section: Resultsmentioning

confidence: 99%

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confidence: 98%

Alkaloids, Amides and Antispasmodic Activity of Zanthoxylum hyemale

et al. 2002

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“…Atividades biológicas: Um estudo realizado com a casca da raiz registrou forte atividade estimulante em útero de ratas (Barros et al, 1970). Estudos realizados por Bolzani et al (1996Bolzani et al ( , 1997 com os iridóides (ferulato de 11-O-trans-teucreína e α e β-gardiol) isolados dos ramos e folhas, apresentaram atividade antifúngica contra Cladosporium cladosporioides.…”

Section: (Jpb)unclassified

Estudo farmacobotânico das folhas de Tocoyena formosa (Cham. & Schltdl.) K.Schum. (Rubiaceae)

Coelho¹,

Agra²,

Barbosa³

2006

Rev. bras. farmacogn.

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RESUMO:Este trabalho teve como objetivo um estudo farmacobotânico das folhas de Tocoyena formosa (Cham. & Schltdl.) K. Schum., espécie usada na medicina popular do Nordeste do Brasil no tratamento das dores reumáticas. Realizaram-se estudos morfológicos para a identifi cação da espécie e para a morfodiagnose macroscópica. Cortes paradérmicos e transversais do pecíolo e da lâmina foliar, à mão livre, foram corados com safranina ou com uma mistura de safranina e azul de astra para a morfodiagnose microscópica. A lâmina foliar é subcoriácea, oblongo-lanceolada a elíptica, densamente tomentosa na face abaxial. T. formosa possui folhas hipoestomáticas, com estômatos do tipo paracítico; epiderme unisseriada com células de paredes poligonais; mesofi lo dorsiventral com idioblastos cristalíferos, esparsos, isolados ou aos pares, no estrato superior do parênquima paliçádico; tricomas simples são evidentes na epiderme, em ambas faces. A vascularização é formada por dois feixes assessórios na posição adaxial e um feixe central em arco com as terminações invaginadas, na porção proximal do pecíolo, ou em forma de "V-fechado" na porção distal e na nervura principal. A morfologia das estruturas vegetativas e reprodutivas associada à anatomia do mesofi lo e do sistema vascular, em conjunto, são caracteres distintivos para esta espécie.Unitermos: Tocoyena formosa, Rubiaceae, plantas medicinais, farmacobotânica.ABSTRACT: "Pharmacobotanical study of the leaves of Tocoyena formosa (Cham. & Schltdl.) K.Schum. (Rubiaceae)". This work constitutes a pharmacobotanical study of Tocoyena formosa (Cham. & Schltdl.) K. Schum., a species used in folk medicine for rheumatic pains in Northeastern Brazil. The botanical identifi cation and macroscopical morphodiagnosis were carried out by morphological studies. The microscopical morphodiagnosis were realized by paradermic and transversal cuts of the leaves (blades and petiole) and stained with safranin or mixture of safranin and astrablue. The blade leaf is subcoriaceous and oblong-lanceolate to elliptic, densely tomentose in the abaxial surface. T. formosa has hypostomatic leaves with stomata of the paracitic type; unisseriate epidermis with polygonal cells; the mesophyll is dorsiventral and the parenchyma palisade has sparse idioblasts crystallifer, isolated or paired; trichomes simple were evident in the epidermis of both faces. The vascular system was formed by two accessories bundles in the adaxial surface and by one central vascular bundle in arc with invaginate extremities on the proximal portion of petiole, and in shape of "V-closed" on distal portion of the petiole and main vein. The vegetative and reproductive morphologies associate to the anatomy of mesophyll and vascular system constitute a set of characters distinctive for this species.

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“…Matos and Gottlieb (1967) isolated and identified the active component as isocucurbitacin B. Several activities as decongestant, hemolytic, purgative and abortifacient have been attributed to this plant (Le Cointe 1947, Silva 1964, Barros et al 1970. Its effect on Allium cepa root tip cells has been recently studied by Medeiros and Takahashi (1987).…”

Section: Action Of Luffa Operculata (Cucurbitaceae) On the Chromosomementioning

confidence: 99%